Readily absorbed from the GI tract, widely distributed in body tissues and fluids including the CSF and metabolised in liver. It is excreted mainly in the urine as conjugates and metabolites and to a lesser extent in faeces.
BACTERIAL VAGINOSIS: 1.5g single dose for one day. Alternatively, 500mg ODX5-7 days can also be used.
ANAEROBIC BACTERIAL INFECTIONS: 500mg b.i.d.x5-10 days.
ANAEROBIC BACTERIAL INFECTIONS: Treatment: Initially IV INFUSION OF 0.5 1G, FOLLOWED by 0.5g every 12hrs x 5-10 days; oral therapy substituted at the earliest opportunity. In children, 10mg/kg every 12 hrs. Surgical prophylaxis: 1g given by IV infusion 30 min prior to surgical procedure.
Omnidazole is active against protozoa and anaerobic bacteria and is used like metronidazole in the management in the mangement of susceptible protozoal anaerobic bacterial infections. Ornidazole’s longer half-life(12-14 hrs) in comparison to that of metronidazole (6-8 hrs) os of particular advantage, for it favorably reduces the dosage frequency and duration of therpay in many of the relevant clinical infections.
Adverse Effect &
Nausea, abdominal pain, vertigo, skin rash, headache.
Precaution: Ataxia, vertigo, metal confusion.