Drug Information

 


     















Pharmacokinetics

When given orally Oxyphenbutazone is completely
absorbed. It is 98% plasma bound. It is metabolised in the liver by
hydroxylation and glucuronidation. The plasma t1/2 is nearly about 60hrs
.

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Indication
& Dosage


 



Oral

ACUTE GOUT, & EXACERBATIONS OF RHEUMATOID ARTHRITIS & ALLIED
CONDITIONS:
100-200MG
b.i.d/t.i.d

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Action




It is p-hydroxy along of & one of the active metabolites of
phenylbutazone, haveing marked anti-inflammatory effect. Its potential
for serious toxicity, however, limits its use in long-term therapy.

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Interaction

Oxyphenbutazone potentiates the action of
anticoagulants like warfarin and oral hypoglycaemic agents. It increases
the toxicity of Methotrexate by reducing its renal clearance and
displacing it from it plasma protein. Oxyphenbutazone also inhibits the
metabolism of Phenytoin and also reduces the hypotensive effect of
beta-blockers.

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Adverse Effect &
Precautions


Precaution has to be taken in dyspepsia, hypertention
and in lactation.

Pregnancy: Contraindicated.

Breast Feeding: Use with caution.

Man: Use is inadvisable.

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Brands
available in market














PHENABID

IDPL
TAB 100mg 10 4.09
SIORIL

Albert David
TAB 100mg 10 5.40


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Drug Information
 

     

Pharmacokinetics

When given orally Oxyphenbutazone is completely absorbed. It is 98% plasma bound. It is metabolised in the liver by hydroxylation and glucuronidation. The plasma t1/2 is nearly about 60hrs.

TOP
   

Indication & Dosage
 

Oral
ACUTE GOUT, & EXACERBATIONS OF RHEUMATOID ARTHRITIS & ALLIED CONDITIONS:
100-200MG b.i.d/t.i.d

TOP
   

Action

It is p-hydroxy along of & one of the active metabolites of phenylbutazone, haveing marked anti-inflammatory effect. Its potential for serious toxicity, however, limits its use in long-term therapy.

TOP
   

Interaction

Oxyphenbutazone potentiates the action of anticoagulants like warfarin and oral hypoglycaemic agents. It increases the toxicity of Methotrexate by reducing its renal clearance and displacing it from it plasma protein. Oxyphenbutazone also inhibits the metabolism of Phenytoin and also reduces the hypotensive effect of beta-blockers.

TOP
   

Adverse Effect & Precautions

Precaution has to be taken in dyspepsia, hypertention and in lactation.
Pregnancy: Contraindicated.
Breast Feeding: Use with caution.
Man: Use is inadvisable.

TOP
   

PHENABID

IDPL

TAB

100mg

10

4.09

SIORIL

Albert David

TAB

100mg

10

5.40

TOP
   

 

                                                                                                    

By |2022-07-20T16:42:54+00:00July 20, 2022|Uncategorized|Comments Off on Oxyphenbutazone

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