Oxytocin

Pharmacokinetics

After administration it has a
short plama half life.

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Indication
& Dosage

 


IM/IV

UNDER FULL OBSTETRIC SUPERVISION TO SHORTEN THIRD STAGE OF LABOR
FOLLOWING DELIVER OF ANTERIOR SHOULDER; ROUTINE MANAGEMENT AFTER
DELIVERY OF PLACENTA; POSTPARTUM OR POSTABORTAL ATONY & HEMORRHAGE:
0.2mg IM; may be repeated as reqd, at intervals of 2-4 hrs. IV use is
not routinely advocated unless as an emergency measure. IV DOSE SAME AS
IM DOSE.




ORAL

MILD POSTPARTUM HEMORRHAGE; UTERINE SUBINVOLUTION: 0.2mg t.i.d/q.i.d. in
the pureperuim for a maximum of one week.

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Action




Selective stimulant on uterine muscle especially towards term, during
labour and postpartum. Sensitivity of the uterus to oxytocin increases
throughout the pregnancy reaching the maximum at term.

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Interaction



Sympathomimetics: Pressor
effect of sympathomimetics may be increased leading to postpartum
hypertension.

Prostaglandins: Risk of uterine rupture and cerival lacerations.

Ergotamine: Synergistic effect in control of post partum hemorrhage.

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Adverse Effect &
Precautions




Inj: Tachycardia, hypotension,
ECG changes water intoxication.



Precaution: I.V. Infusion to be given under close medical supervision
and careful monitoring of the patient is to be done, cardiovascular
disorders, hypersensitivity.

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Brands
available in market

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