Drug
Information


 


     











Pharmacokinetics


It is rapidly absorbed after oral administration. The drug is subject to
low first-pass hepatic extraction. displaying an estimated absolute oral
bioavailability of 77%. Concomitant food intake does not affect
bioavailability.

Elimination is predominantly renal, with 80% of an oral or intravenous
dose being excreted as urinary metabolites, the remainder is excreted in
the faeces and originates primarily from biliary secretion.

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Indication
& Dosage




Oral

DUODENAL AND GASTRIC ULCERS, GASTRO-OESOPHAGIAL REFLUX DISEASE AND
SOLLINGER-ELLISON SYNDROME: Adults: 40mg once daily for 2-8 weeks.

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Action

Pantoprazole inhibits the proton pump(H+, K_ATPPase) function there
by healing the acid related conditions. Pantoprazole is chemically more
stable than Omeprazole and lansoprazole in neutral to midly acidic
conditions, but under strongly acidic milieuu, active species is formed.
Pantaprazole like Omeprazole and Lansoprazole also has a role in the
eradication of helicobacteria Pylori.

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Interaction

Phenazone (antipyrine), diazepam, digoxin, theophylline,
carbamazepine, diclofenac, phenprocoumon, phenytoin, warfarin,
nifedipine, caffeine, metoprolol, or ethanol: No clinically relevant
interaction at therapeutic doses.

Oral contraceptives: Does not apper to compromise hormonal contraceptive
efficacy as no interaciton with a low dose combined oral contraceptive
has been seen.

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Adverse Effect & Precautions




Diarrhoea, dizziness, pruritus and skin rash



Pregnancy: Safety not established.

Breast Feeding: Safety not established.

Man: Use with caution.

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Brands
available in market


 













PANTOCID

Sun
E-C TAB 40mg 10 60.00
PANTODAC

Alidac
E-C TAB 40mg 7 42.00
ZOVANTA

DR. Reddy’s
E-C TAB 40mg 10 59.40




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Drug Information
 

     

Pharmacokinetics

It is rapidly absorbed after oral administration. The drug is subject to low first-pass hepatic extraction. displaying an estimated absolute oral bioavailability of 77%. Concomitant food intake does not affect bioavailability.
Elimination is predominantly renal, with 80% of an oral or intravenous dose being excreted as urinary metabolites, the remainder is excreted in the faeces and originates primarily from biliary secretion.

Top
   

Indication & Dosage

Oral
DUODENAL AND GASTRIC ULCERS, GASTRO-OESOPHAGIAL REFLUX DISEASE AND SOLLINGER-ELLISON SYNDROME: Adults: 40mg once daily for 2-8 weeks.

Top
   

Action

Pantoprazole inhibits the proton pump(H+, K_ATPPase) function there by healing the acid related conditions. Pantoprazole is chemically more stable than Omeprazole and lansoprazole in neutral to midly acidic conditions, but under strongly acidic milieuu, active species is formed. Pantaprazole like Omeprazole and Lansoprazole also has a role in the eradication of helicobacteria Pylori.

Top
   

Interaction

Phenazone (antipyrine), diazepam, digoxin, theophylline, carbamazepine, diclofenac, phenprocoumon, phenytoin, warfarin, nifedipine, caffeine, metoprolol, or ethanol: No clinically relevant interaction at therapeutic doses.
Oral contraceptives: Does not apper to compromise hormonal contraceptive efficacy as no interaciton with a low dose combined oral contraceptive has been seen.

Top
   

Adverse Effect & Precautions

Diarrhoea, dizziness, pruritus and skin rash

Pregnancy: Safety not established.
Breast Feeding: Safety not established.
Man: Use with caution.

Top
   

PANTOCID

Sun

E-C TAB

40mg

10

60.00

PANTODAC

Alidac

E-C TAB

40mg

7

42.00

ZOVANTA

DR. Reddy’s

E-C TAB

40mg

10

59.40

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By |2022-07-20T16:45:02+00:00July 20, 2022|Uncategorized|Comments Off on Pantoprazole

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