|
Drug
Information
Pharmacokinetics
| Indication
& Dosage | Action
| Interacations |
Adverse
Effects&Precautions |
Brands available in Market
It is rapidly absorbed after oral administration. The drug is subject to
low first-pass hepatic extraction. displaying an estimated absolute oral
bioavailability of 77%. Concomitant food intake does not affect
bioavailability.
Elimination is predominantly renal, with 80% of an oral or intravenous
dose being excreted as urinary metabolites, the remainder is excreted in
the faeces and originates primarily from biliary secretion.
Indication
& Dosage
Oral
DUODENAL AND GASTRIC ULCERS, GASTRO-OESOPHAGIAL REFLUX DISEASE AND
SOLLINGER-ELLISON SYNDROME: Adults: 40mg once daily for 2-8 weeks.
Pantoprazole inhibits the proton pump(H+, K_ATPPase) function there by healing the acid related conditions. Pantoprazole is chemically more stable than Omeprazole and lansoprazole in neutral to midly acidic conditions, but under strongly acidic milieuu, active species is formed. Pantaprazole like Omeprazole and Lansoprazole also has a role in the eradication of helicobacteria Pylori.
Phenazone (antipyrine), diazepam, digoxin, theophylline,
carbamazepine, diclofenac, phenprocoumon, phenytoin, warfarin,
nifedipine, caffeine, metoprolol, or ethanol: No clinically relevant
interaction at therapeutic doses.
Oral contraceptives: Does not apper to compromise hormonal contraceptive
efficacy as no interaciton with a low dose combined oral contraceptive
has been seen.
Adverse Effect & Precautions
Diarrhoea, dizziness, pruritus and skin rash
Pregnancy: Safety not established.
Breast Feeding: Safety not established.
Man: Use with caution.
