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Drug Information
Pharmacokinetics
| Indication
& Dosage | Action
| Interacations |
Adverse Effects
& Precautions |
Brands available in Market
It is well absorbed after oral administration. About 1/3rd of it gets protein bound and uniformly distributed in the body. The drug gets conjugated with glucuronic acid and gets rapidly excreted in urine. Plasma half life is about 2-3 hrs.Effect after a oral dose last for 3-5 hours.
Indication
& Dosage
Oral
MILD TO MODERATE PAIN AND FEVER: Adult: Usual dose is 0.5-1g every 4-6
hrs up to a mximum of 4g daily. Children: Under 3 months-10mg/kg
body-wt. 3 months-1yr-60-120mg. 1yr-5yr-120mg-250mg.6yr-12yr-250-500mg.
The above dose 3-4 times daily as required.
Paracetamol has analgesic and antipyretic action with weak anti inflammatory activity.These effects are related to inhibition of prostaglandin synthesis. It is an analgesic-antipyretic of choice especially in patients in whom salicylates or other NSAIDs are contraindicated. Such cases include asthmatics, peptic ulcer patients, children in whom salicylates are not used because of the risk Reye’s syndrome.
It can increase the effect of anticoagulants, it can increase hepatic damage in alcoholics. Pethidine and propantheline can reduce the absorption of paracetamol.
Some brands of Paracetamol contain aspartame, which can make Phenylketonuria worse. The chance of serious adverse effects may be increased in alcohol abuse, renal disease and in Hepatitis.
