Drug Information

   


     











Pharmacokinetics

Penicillin gets widely distributed through out the
body and reaches high concentration in the urine. It also reaches
significant level in bile, liver, skeletal muscle, brain and plasma. Its
level gets raised in the presence of inflammation.

Top

   

Indication
& Dosage




Penicillin acts against Gram positive & some Gram negative
organisms.It is effective against H. Influenza, Strep.Viridans, Proteus,
Neisseria Gonorrhoea and Salmonella etc. Penicillin G: For bacterial
infections: For oral dosage form (oral solution, oral suspension, and
tablets): Adults: 200,000 to 500,000 Units every four to six hours.
Infants and children less than 12 years of age: Dose is based on body
weight – 4000 to 30,000 Units per kilogram (kg) of body weight every
four to eight hours. For benzathine Penicillin (injection): Adults :
1,200,000 to 2,400,000 Units injected intramuscular as a single dose.
Infants and children: 300,000 to 1,200,000 Units injected intramuscular
as a single dose; or 50,000 Units per kg of body weight injected
intramuscular as a single dose. For injection dosage forms (potassium
and sodium salts): Adults: 1,000,000 to 5,000,000 Units, injected
intravenous or intramuscular every four to six hours. Older infants and
children : The usual dose is 8000 to 25,000 Units per kg of body weight,
injected intravenous or intramuscular every four to six hours. Premature
infants and newborns : The usual dose is 30,000 Units per kg of body
weight, injected I.V. or I.M.every twelve hours. For Procaine Penicillin
(injection) : Adults and teenagers : 600,000 to 1,200,000 Units injected
I.M. once a day. Children: The usual dose is 50,000 Units per kg of body
weight, injected I.M.once a day. For penicillin V: For bacterial
infections: For the benzathine salt oral dosage form (oral solution):
Adults: 200,000 to 500,000 Units every six to eight hours.Children:
100,000 to 250,000 Units every six to eight hours. For the potassium
salt oral dosage: Adults and teenagers : 125 to 500 milligrams (mg)
every six to eight hours. Children :The usual dose is 2.5 to 16 mg per
kilogram (kg) of body weight every four to eight hours.

Top

   

Interaction

Oral contraceptives containing estrogen : Use of
Penicillins together with estrogen-containing oral contraceptives may
prevent oral contraceptives from being effective, increasing the chance
of pregnancy. Methotrexate : Use of methotrexate with penicillin may
increase the chance of side effects of methotrexate. Probenecid :
Probenecid causes penicillin to build up in the blood. This may increase
the chance of adverse effects.

Top

   



Precautions

In Allergy: Patients with a history of general
allergies may be more likely to have a severe reaction to penicillin.
Renal disease: Patients with renal disease may have an increased chance
of side effects. Mononucleosis : Patients with mononucleosis may have an
increased chance of skin rash when receiving penicillin. Stomach or
intestinal disease (especially colitis, including colitis caused by
antibiotics) : Patients with a history of stomach or intestinal disease
may be more likely to develop colitis while taking penicillin.

Top

   

Brands
available in market























LARAP

LA Pharma
TAB 2mg 10 14.80
TAB 4mg 10 27.60
MOZEP

Intas
TAB 2mg 10 30.00
TAB 4mg 10 42.50
NEURAP

Torrent
TAB 2mg 10 29.90
TAB 4mg 10 42.40
ORAP

Ethnor
TAB 2mg 10 39.00
TAB 4mg 10 55.00
TAB 10mg 10 110.29
PIMODAC

Alidac
TAB 2mg 10 11.50
TAB 4mg 10 17.20








Top

  



 






 

     

    
Drug Information
   

     

Pharmacokinetics

Penicillin gets widely distributed through out the body and reaches high concentration in the urine. It also reaches significant level in bile, liver, skeletal muscle, brain and plasma. Its level gets raised in the presence of inflammation.

Top
   

Indication & Dosage

Penicillin acts against Gram positive & some Gram negative organisms.It is effective against H. Influenza, Strep.Viridans, Proteus, Neisseria Gonorrhoea and Salmonella etc. Penicillin G: For bacterial infections: For oral dosage form (oral solution, oral suspension, and tablets): Adults: 200,000 to 500,000 Units every four to six hours. Infants and children less than 12 years of age: Dose is based on body weight – 4000 to 30,000 Units per kilogram (kg) of body weight every four to eight hours. For benzathine Penicillin (injection): Adults : 1,200,000 to 2,400,000 Units injected intramuscular as a single dose. Infants and children: 300,000 to 1,200,000 Units injected intramuscular as a single dose; or 50,000 Units per kg of body weight injected intramuscular as a single dose. For injection dosage forms (potassium and sodium salts): Adults: 1,000,000 to 5,000,000 Units, injected intravenous or intramuscular every four to six hours. Older infants and children : The usual dose is 8000 to 25,000 Units per kg of body weight, injected intravenous or intramuscular every four to six hours. Premature infants and newborns : The usual dose is 30,000 Units per kg of body weight, injected I.V. or I.M.every twelve hours. For Procaine Penicillin (injection) : Adults and teenagers : 600,000 to 1,200,000 Units injected I.M. once a day. Children: The usual dose is 50,000 Units per kg of body weight, injected I.M.once a day. For penicillin V: For bacterial infections: For the benzathine salt oral dosage form (oral solution): Adults: 200,000 to 500,000 Units every six to eight hours.Children: 100,000 to 250,000 Units every six to eight hours. For the potassium salt oral dosage: Adults and teenagers : 125 to 500 milligrams (mg) every six to eight hours. Children :The usual dose is 2.5 to 16 mg per kilogram (kg) of body weight every four to eight hours.

Top
   

Interaction

Oral contraceptives containing estrogen : Use of Penicillins together with estrogen-containing oral contraceptives may prevent oral contraceptives from being effective, increasing the chance of pregnancy. Methotrexate : Use of methotrexate with penicillin may increase the chance of side effects of methotrexate. Probenecid : Probenecid causes penicillin to build up in the blood. This may increase the chance of adverse effects.

Top
   

Precautions

In Allergy: Patients with a history of general allergies may be more likely to have a severe reaction to penicillin. Renal disease: Patients with renal disease may have an increased chance of side effects. Mononucleosis : Patients with mononucleosis may have an increased chance of skin rash when receiving penicillin. Stomach or intestinal disease (especially colitis, including colitis caused by antibiotics) : Patients with a history of stomach or intestinal disease may be more likely to develop colitis while taking penicillin.

Top
   

LARAP

LA Pharma

TAB

2mg

10

14.80

TAB

4mg

10

27.60

MOZEP

Intas

TAB

2mg

10

30.00

TAB

4mg

10

42.50

NEURAP

Torrent

TAB

2mg

10

29.90

TAB

4mg

10

42.40

ORAP

Ethnor

TAB

2mg

10

39.00

TAB

4mg

10

55.00

TAB

10mg

10

110.29

PIMODAC

Alidac

TAB

2mg

10

11.50

TAB

4mg

10

17.20


Top
  

 

 

By |2022-07-20T16:44:58+00:00July 20, 2022|Uncategorized|Comments Off on Penicillins

About the Author: