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Drug Information
Pharmacokinetics
| Indication
& Dosage | Action
| Interacations |
Adverse
Effects & Precautions |
Brands available in Market
Mean elimination half-lives for pilocarpine have been reported to be 0.76 and 1.35 hours following oral administration of 5 and 10 mg doses of the hydrochloride respectively. Inactivation of pilocarpine is thought to occur at neuronal synapses and probably in plasma. Pilocarpine and its inactive metabolites, including pilocarpic acid, are excreted in the urine.
Topical Eye
GLAUCOMA, REDUCTION OF ELEVATED INTRA-OCULAR PRESSURE TO LOOSEN
ANDHESIONS BETWEEN IRIS AND LENS: 1%, 2% OR 4% 1 OR 2 drops in the eye
as required
Acting on the motor cortex, phenytoin prevents spread of seizure activity. Stabilises threshold for hyperexcitability and reduces posttetanic potentiation at synapsi. Reduces brain stem activity responsible for the tonic phase of tonic-clonic convulsion. Also, a useful antiarrhythmic,
Local irritation, painful, spasm of
accommodation resulting in blurring of vision and browache.
Precaution: Follicular conjunctivitis is an allergic reaction which
occur in senstive individual on chronic use, Acute eyes infection,
children, corneal damage.
Pregnancy: Use with caution.
Breast Feeding: Use with caution.
Man: May be used.
