Drug Information

   


     












Pharmacokinetics



Following oral administration,
more than half of a dose of pimozide is reported to be absorbed. It
undergoes significant first-pass metabolism. Peak plasma concentrations
have been reported after 4 to 12 hours and there is a considerable
interindividual variation in the concentrations achieved. Pimozide is
metabolised in the liver mainly by N-dealkylation and excreted in the
urine and faeces, both unchanged and in the form of metabolites.
Pimozide has a long terminal half-life generally considered to be
approximately 55 hours, although half-lives of up to 150 hours have been
noted in some patients.

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Indication
& Dosage




Oral

CHRONIC SCHIZOPHRENIA, INITIAL THERAPY IN NEW PSYCHOTICS, TOURETTE’S
DISORDER: Start with 1-2mg/day. Increase progressively Optimum daily
dose: 2-5mg. Children : not recommended below 12 yrs.

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Action



Blocks dopaminergic receptors in the CNS.

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Interaction

The risk of arrhythmias with
pimozide may be increased by other drugs which prolong the QT interval
and by the HIV-protease inhibitor ritonavir which raises plasma
concentrations of pimozide; concomitant use should be avoided.
Concomitant use should also be avoided with drugs which induce
electrolyte disturbances and with macrolide antibacterials.

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Adverse Effect & Precautions





Mania, insomnia, nervousness, fatigue, drowsiness, nausea,
extrapyramidal reactions and irritability.

Precaution:
Hepatic and renal disease. ECG to be done before giving drug therapy

Pregnancy: Use with caution.

Breast Feeding: Use with caution.

Man: May be given in reduced dose.

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Brands
available in market























LARAP

LA Pharma
TAB 2mg 10 14.80
TAB 4mg 10 27.60
MOZEP

Intas
TAB 2mg 10 30.00
TAB 4mg 10 42.50
NEURAP

Torrent
TAB 2mg 10 29.90
TAB 4mg 10 42.40
ORAP

Ethnor
TAB 2mg 10 39.00
TAB 4mg 10 55.00
TAB 10mg 10 110.29
PIMODAC

Alidac
TAB 2mg 10 11.50
TAB 4mg 10 17.20









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Drug Information
   

     

Pharmacokinetics

Following oral administration, more than half of a dose of pimozide is reported to be absorbed. It undergoes significant first-pass metabolism. Peak plasma concentrations have been reported after 4 to 12 hours and there is a considerable interindividual variation in the concentrations achieved. Pimozide is metabolised in the liver mainly by N-dealkylation and excreted in the urine and faeces, both unchanged and in the form of metabolites. Pimozide has a long terminal half-life generally considered to be approximately 55 hours, although half-lives of up to 150 hours have been noted in some patients.

Top
  

Indication & Dosage

Oral
CHRONIC SCHIZOPHRENIA, INITIAL THERAPY IN NEW PSYCHOTICS, TOURETTE’S DISORDER: Start with 1-2mg/day. Increase progressively Optimum daily dose: 2-5mg. Children : not recommended below 12 yrs.

Top
  

Action

Blocks dopaminergic receptors in the CNS.

Top
  

Interaction

The risk of arrhythmias with pimozide may be increased by other drugs which prolong the QT interval and by the HIV-protease inhibitor ritonavir which raises plasma concentrations of pimozide; concomitant use should be avoided. Concomitant use should also be avoided with drugs which induce electrolyte disturbances and with macrolide antibacterials.

Top
  

Adverse Effect & Precautions

Mania, insomnia, nervousness, fatigue, drowsiness, nausea, extrapyramidal reactions and irritability.

Precaution: Hepatic and renal disease. ECG to be done before giving drug therapy
Pregnancy: Use with caution.
Breast Feeding: Use with caution.
Man: May be given in reduced dose.

Top
  

LARAP

LA Pharma

TAB

2mg

10

14.80

TAB

4mg

10

27.60

MOZEP

Intas

TAB

2mg

10

30.00

TAB

4mg

10

42.50

NEURAP

Torrent

TAB

2mg

10

29.90

TAB

4mg

10

42.40

ORAP

Ethnor

TAB

2mg

10

39.00

TAB

4mg

10

55.00

TAB

10mg

10

110.29

PIMODAC

Alidac

TAB

2mg

10

11.50

TAB

4mg

10

17.20


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By |2022-07-20T16:41:22+00:00July 20, 2022|Uncategorized|Comments Off on Pimozide

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