Drug Information

    



       











Pharmacokinetics

Piperacillin is acid sensitive. It is eliminated by
glomerular filtration & tubular secretion in the kidneys.

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Indication
& Dosage





IM/IV

SERIOUS INFECTIONS CAUSED BY SUSCEPTIBLE ORGANISMS LIFE-THREATENING
PAEDIATRIC INFECTION: Less severe infection 6-8g/day. In severe and
complicated infection 6-8g/day. In severe and complicated infections
12-18g/day in 4 equally div doses 7-10 days. Children: 100-300mg/kg/day
in 3-4 div doses. 7-10day.

PREOPERATIVE PROPHYLAXIS: 3 doses of 2g each IV OR IM. First dose given
1-2hrs beforem 2nd dose towards the end and the 3rd dose 6hrs after
surgery.

NOTE: Renal impairment: Dose modification related to creatinine
clearance (CC)





CC(ml/min) UTI Syst infection
20-40

less than 20
3g/8hrly

3g/12 hrly
4g/8 hrly

4g/12 hrly


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Action



Broad spectrum of activity against all major Gram-positive and
Gram-negative organisms except those producing betalactamases. The most
active penicillin against Gram-Negative and pseudomonas aeruginosa.
Bactericidal through inhibition of bacterial cell wall synthesis.

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Interaction

Piperacillin clearance is reduced by
Probenecid.

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Precautions



Platelet dysfunction leading to bleeding. Superinfection, local pain,
thrombophlebitis, lactation






Precaution to be taken while taking cephalosporins.

Pregnancy: May be used.

Breast Feeding: Use with caution

Man: May be used.






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Brands
available in market













PIPRACIL

Wyeth Lederle
INJ 2gm VIAL 248.80
INJ 4gm VIAL 414.50
PIPRAPEN INJ

FDC
INJ 1gm VIAL 80.00
INJ 2gm VIAL 148.00








Top

   







 

        

 
Drug Information
    

       

Pharmacokinetics

Piperacillin is acid sensitive. It is eliminated by glomerular filtration & tubular secretion in the kidneys.

Top
   

Indication & Dosage

IM/IV
SERIOUS INFECTIONS CAUSED BY SUSCEPTIBLE ORGANISMS LIFE-THREATENING PAEDIATRIC INFECTION: Less severe infection 6-8g/day. In severe and complicated infection 6-8g/day. In severe and complicated infections 12-18g/day in 4 equally div doses 7-10 days. Children: 100-300mg/kg/day in 3-4 div doses. 7-10day.
PREOPERATIVE PROPHYLAXIS: 3 doses of 2g each IV OR IM. First dose given 1-2hrs beforem 2nd dose towards the end and the 3rd dose 6hrs after surgery.
NOTE: Renal impairment: Dose modification related to creatinine clearance (CC)

CC(ml/min)

UTI

Syst infection

20-40
less than 20

3g/8hrly
3g/12 hrly

4g/8 hrly
4g/12 hrly

Top
   

Action

Broad spectrum of activity against all major Gram-positive and Gram-negative organisms except those producing betalactamases. The most active penicillin against Gram-Negative and pseudomonas aeruginosa. Bactericidal through inhibition of bacterial cell wall synthesis.

Top
   

Interaction

Piperacillin clearance is reduced by Probenecid.

Top
   

Precautions

Platelet dysfunction leading to bleeding. Superinfection, local pain, thrombophlebitis, lactation


Precaution to be taken while taking cephalosporins.
Pregnancy: May be used.
Breast Feeding: Use with caution
Man: May be used.


Top
   

PIPRACIL

Wyeth Lederle

INJ

2gm

VIAL

248.80

INJ

4gm

VIAL

414.50

PIPRAPEN INJ

FDC

INJ

1gm

VIAL

80.00

INJ

2gm

VIAL

148.00


Top
   

 

By |2022-07-20T16:45:00+00:00July 20, 2022|Uncategorized|Comments Off on Piperacillin

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