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Drug Information
Pharmacokinetics
| Indication
& Dosage | Action
| Interacations |
Adverse
Effects & Precautions |
Brands available in Market
It is completely absorbed after oral administration. It undergoes enterohepatic cycling and is extensively bound to plasma proteins.
Oral
RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, ANKYLOSING SPONDYLITIS, ACUTE
GOUT, OTHER PAINFUL CONDITIONS ASSOCIATED WITH MUSCULO-SKELETAL TISSUES:
10-30mg daily. Acute disorders including acute gout: 40mg daily as a
single or 2 divided doses for 7-14 days. Shorter duration of 4-6 days
for gout. DYSMENORRHOEA: Start with 40mg daily. Reduce as possible
IM
POSTOPERATIVE AND POSTTRAUMA PAIN, ACUTE MUSCULO-SKELETAL DISORDERS:
20mg give IM.
Action
Belongs to the oxicam group of NSAID’s. It has a prolonged
half-life and can be given in once a day dosage. Inhibits the enzyme
cyclo-oxygenase in the pathway of prostaglandin synthesis. Exerts
anti-inflammatory, analgesic and antipyretic action.
Concurrent administration of aspirin results in decreased plasma concentrations of piroxicam to about 80% of normal. Concomitant administration of piroxicam and ritonavir may result in increased plasma concentrations of piroxicam and carries an increased risk of toxicity; use together should be avoided.
Adverse Effect & Precautions
Nausea, heart burn, vomiting, epigastric distress, tinnitus, skin rash,
oedema.
Precaution: Severe impairment of hepatiac or renal function.
Hypertension, surgery haemorrhagic disorders. Prolonged use.
Pregnancy: Contraindicated.
Breast Feeding: Conraindicated.
Man: Use with caution.
