Drug Information

    


   











Pharmacokinetics


After administration it is metabolised in liver.

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Indication
& Dosage




IM/IV

POISONING DUE TO ORGANOPHOSPHATE COMPUNDS SUCH AS MALATHION, PARATHION,
FENTHION, TEPP, DICHLOROS ETC: 1-2g of pralidoxime along with 2-4mg
of 1-2g of pralidoxme along with 2-4mg of atropine give IM OR IV as 5%
solution in atropine given IM OR IV as 5% solution in water over 5-10min
or infuse in 100ml normal saline over 15-30 min. Repeat after 1hr and
then hourly with care if muscle weakness persists. Children: Pralidoxime
20-40mg/kg and atropine 0.05-0.1mg/kg. In both adults and 
children, atropine might have to be injected frequently to relieve
respiratory depression. Full resuscitative measures should be always
utilised.

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Action



Reactivates cholinesterase outside the CNS which has been
inactivated by organophosphate pesticides and related compounds. This
leads to destruction of the excessive acetylcholine blocking the
neuromuscular function. The latter starts functioning again. Pralidoxime
is effective in relieving paralysis of respiratory muscles. It is
usually given in conjucntion with atropine to treat OP poisoning.

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Interaction

Barbiturates: Use with caution in treatment of
convulsions becuase barbiturates are potentiated by anticholinerase.

Morphine, Theophilline, Aminophylline, SUccinylcholine, Reserpine and
Phenothiazines: Avoid in patients with organophosphorus poisoning

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Adverse Effect & Precautions



Blurred vision, dizziness, diplopia, headache, tachycardia, mild
weakness and nausea. In high dose it can cause neuromuscular blockade.



Precautions: It should be administered after atropine injection,
Myasthenia Gravis.

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Brands
available in market















PAM

VHB
INJ 1g VIAL 310.00
PAM TABS

Shree Ganesh
TAB 500mg 50 20.00
PAM-A INJECTION

Panacea
INJ 500mg 20ML 285.00
PAM-A KOREA

Shree Ganesh
INJ 500mg 20ml 175.00



Top

   







     

   
Drug Information
    

   

Pharmacokinetics

After administration it is metabolised in liver.

Top
   

Indication & Dosage

IM/IV
POISONING DUE TO ORGANOPHOSPHATE COMPUNDS SUCH AS MALATHION, PARATHION, FENTHION, TEPP, DICHLOROS ETC: 1-2g of pralidoxime along with 2-4mg of 1-2g of pralidoxme along with 2-4mg of atropine give IM OR IV as 5% solution in atropine given IM OR IV as 5% solution in water over 5-10min or infuse in 100ml normal saline over 15-30 min. Repeat after 1hr and then hourly with care if muscle weakness persists. Children: Pralidoxime 20-40mg/kg and atropine 0.05-0.1mg/kg. In both adults and  children, atropine might have to be injected frequently to relieve respiratory depression. Full resuscitative measures should be always utilised.

Top
   

Action

Reactivates cholinesterase outside the CNS which has been inactivated by organophosphate pesticides and related compounds. This leads to destruction of the excessive acetylcholine blocking the neuromuscular function. The latter starts functioning again. Pralidoxime is effective in relieving paralysis of respiratory muscles. It is usually given in conjucntion with atropine to treat OP poisoning.

Top
   

Interaction

Barbiturates: Use with caution in treatment of convulsions becuase barbiturates are potentiated by anticholinerase.
Morphine, Theophilline, Aminophylline, SUccinylcholine, Reserpine and Phenothiazines: Avoid in patients with organophosphorus poisoning

Top
   

Adverse Effect & Precautions

Blurred vision, dizziness, diplopia, headache, tachycardia, mild weakness and nausea. In high dose it can cause neuromuscular blockade.

Precautions: It should be administered after atropine injection, Myasthenia Gravis.

Top
   

PAM

VHB

INJ

1g

VIAL

310.00

PAM TABS

Shree Ganesh

TAB

500mg

50

20.00

PAM-A INJECTION

Panacea

INJ

500mg

20ML

285.00

PAM-A KOREA

Shree Ganesh

INJ

500mg

20ml

175.00

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By |2022-07-20T16:42:50+00:00July 20, 2022|Uncategorized|Comments Off on Pralidoxime Chloride

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