Drug Information

 


    
















Pharmacokinetics.




Praziquantel is rapidly
absorbed after administration by mouth, even when taken with a meal;
more than 80% of a dose is reported to be absorbed. Peak plasma
concentrations are achieved 1 to 3 hours after a dose, but there is a
pronounced first-pass effect and praziquantel undergoes rapid and
extensive metabolism in the liver, being hydroxylated to metabolites
that are thought to be inactive. It is distributed into the CSF. The
plasma elimination half-life of praziquantel is 1 to 1.5 hours and that
of the metabolites about 4 hours.

It is excreted in the urine, mainly as metabolites, about 80% of the
dose being eliminated within 4 days and more than 90% of this in the
first 24 hours.

Praziquantel is distributed into breast milk.

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Indication
& Dosage




Oral

NEUROCYSTICERCOSIS: 50mg/kg/day, in 3 divided doses x 15 days.

TAENIA SOLIUM, TAENIA SAGINATA, DIPHYLLOBOTHRIUM LATUM, HYMENOLEPIS
NANA:  Adult & Children: 5-25mg/kg single dose.

SCHISTOSOMIASIS: Adults & Children: 20mg/kg, 3 doses, at 4-6hr
intervals.

CLONORCHIASIS, OPISTHORCHIASIS, LUNG FLUKE, INTESTINAL FLUKE INFECTIONS:
Adult & Children: 25mg/kg t.i.d, x 1-2 days.

Children (under 4yr): Does not established.

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Action



It has a broad spectrum of activity against trematodes (flukes) and
cestodes (tapeworms). It has two major effects on susceptible helminths:
it causes spastic paralysis of worms, & at higher doses it causes
tegumental damage in the worm, which activates host defense mechanism;
this results in destruction of the worms.

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Interaction



Hydantoins: Efficacy of praziqantel decreased leading to treatment
failure.

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Adverse Effect & Precautions



Nausea, abdominal pain, headache, malaise and dizziness.



Precaution: For drug therapy of Neurocysticercosis hospital based
treatment is required.

Pregnancy: Contraindicated.

Breast Feeding: Do not nurse during treatment or subsequent 72 hours.

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Brands
available in market














CYSTICIDE

Merck
TAB 500mg 90 2329.00
DISTOCIDE

VHB
TAB 600mg 8 330.00




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Drug Information
 

    

Pharmacokinetics.

Praziquantel is rapidly absorbed after administration by mouth, even when taken with a meal; more than 80% of a dose is reported to be absorbed. Peak plasma concentrations are achieved 1 to 3 hours after a dose, but there is a pronounced first-pass effect and praziquantel undergoes rapid and extensive metabolism in the liver, being hydroxylated to metabolites that are thought to be inactive. It is distributed into the CSF. The plasma elimination half-life of praziquantel is 1 to 1.5 hours and that of the metabolites about 4 hours.
It is excreted in the urine, mainly as metabolites, about 80% of the dose being eliminated within 4 days and more than 90% of this in the first 24 hours.
Praziquantel is distributed into breast milk.

Top
   

Indication & Dosage

Oral
NEUROCYSTICERCOSIS: 50mg/kg/day, in 3 divided doses x 15 days.
TAENIA SOLIUM, TAENIA SAGINATA, DIPHYLLOBOTHRIUM LATUM, HYMENOLEPIS NANA:  Adult & Children: 5-25mg/kg single dose.
SCHISTOSOMIASIS: Adults & Children: 20mg/kg, 3 doses, at 4-6hr intervals.
CLONORCHIASIS, OPISTHORCHIASIS, LUNG FLUKE, INTESTINAL FLUKE INFECTIONS: Adult & Children: 25mg/kg t.i.d, x 1-2 days.
Children (under 4yr): Does not established.

Top
   

Action

It has a broad spectrum of activity against trematodes (flukes) and cestodes (tapeworms). It has two major effects on susceptible helminths: it causes spastic paralysis of worms, & at higher doses it causes tegumental damage in the worm, which activates host defense mechanism; this results in destruction of the worms.

Top
   

Interaction

Hydantoins: Efficacy of praziqantel decreased leading to treatment failure.

Top
   

Adverse Effect & Precautions

Nausea, abdominal pain, headache, malaise and dizziness.

Precaution: For drug therapy of Neurocysticercosis hospital based treatment is required.
Pregnancy: Contraindicated.
Breast Feeding: Do not nurse during treatment or subsequent 72 hours.

Top
   

CYSTICIDE

Merck

TAB

500mg

90

2329.00

DISTOCIDE

VHB

TAB

600mg

8

330.00

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By |2022-07-20T16:45:09+00:00July 20, 2022|Uncategorized|Comments Off on Praziquantel

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