Drug Information

    


  

















Pharmacokinetics


It shows first pass metabolism in liver and it is highly bound to plasma
protein.

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Indication
& Dosage




Oral

HYPERTENSION ALL GRADES: Start with 0.5mg b.i.d increasing as required
to 1mg t.i.d. Some patients may need upto 20mg daily in divided doses.



Oral Ext. Rel. (GITS)

HYPERTENSION ALL GRADES: 2.5-5mg o.d., preferably at bedtime. Increase
to 10mg o.d. if reqd Max: 20mg o.d.

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Action



Blocks the postsynaptic alpha-1 adrenoceptors causing vasodilatation
and reductionin blood pressure. The effect is seen in resistant vessels.
There is no reflex tachycardia. Diastolic pressure reduced to a greater
extent.


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Interaction

Clonidine: Antihypertensive effect of clonidine may
be decreased.

Beta-adrenergic blocking agents: May enhance ‘first dose’ acute postural
hypotension of prazosin.

Indomethacin: Antihypertensive effect of prazosin decreased.

Verapamil & Nifedipine: Acute hyypotensive effect when
coadministered with prazosin.

Lab Tests: False positive results may occur in screening tests for
phaeochromocytoma in patients receiving prazosin.

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Adverse Effect & Precautions



Postural hypotension, dizziness, faint-ness tachycardia, palpitation,
headache, weight gain, dry mouth, nausea, diarrhoea, constipation, nasal
stuffiness, priapism, skin rash.



Precaution: Pheochromocytoma, hepatic dysfunction, children below 12
years abrupt withdrawal.

Pregnancy: Use with caution. Reduce initial dose.

Breast Feeding: Use with caution. Reduce initial dose.

Man: May be used with caution. Reduce initial dose.

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Brands
available in market
















MINIPRESS XL GITS

Pfizer
TAB 2.5mg 15 68.57
TAB 5mg 15 99.07
PRAZOPRESS

Sun Pharma
TAB 1mg 15 19.40
TAB 2mg 15 37.80



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Drug Information
    

  

Pharmacokinetics

It shows first pass metabolism in liver and it is highly bound to plasma protein.

Top
   

Indication & Dosage

Oral
HYPERTENSION ALL GRADES: Start with 0.5mg b.i.d increasing as required to 1mg t.i.d. Some patients may need upto 20mg daily in divided doses.

Oral Ext. Rel. (GITS)
HYPERTENSION ALL GRADES: 2.5-5mg o.d., preferably at bedtime. Increase to 10mg o.d. if reqd Max: 20mg o.d.

Top
   

Action

Blocks the postsynaptic alpha-1 adrenoceptors causing vasodilatation and reductionin blood pressure. The effect is seen in resistant vessels. There is no reflex tachycardia. Diastolic pressure reduced to a greater extent.

Top
   

Interaction

Clonidine: Antihypertensive effect of clonidine may be decreased.
Beta-adrenergic blocking agents: May enhance ‘first dose’ acute postural hypotension of prazosin.
Indomethacin: Antihypertensive effect of prazosin decreased.
Verapamil & Nifedipine: Acute hyypotensive effect when coadministered with prazosin.
Lab Tests: False positive results may occur in screening tests for phaeochromocytoma in patients receiving prazosin.

Top
   

Adverse Effect & Precautions

Postural hypotension, dizziness, faint-ness tachycardia, palpitation, headache, weight gain, dry mouth, nausea, diarrhoea, constipation, nasal stuffiness, priapism, skin rash.

Precaution: Pheochromocytoma, hepatic dysfunction, children below 12 years abrupt withdrawal.
Pregnancy: Use with caution. Reduce initial dose.
Breast Feeding: Use with caution. Reduce initial dose.
Man: May be used with caution. Reduce initial dose.

Top
   

MINIPRESS XL GITS

Pfizer

TAB

2.5mg

15

68.57

TAB

5mg

15

99.07

PRAZOPRESS

Sun Pharma

TAB

1mg

15

19.40

TAB

2mg

15

37.80

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By |2022-07-20T16:41:34+00:00July 20, 2022|Uncategorized|Comments Off on Prazosin

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