Drug Information

 


  












Pharmacokinetics



The bio-availablity of prednisolone is about 50-80 % after oral
administration. It is metabolized in the liver.

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Indication
& Dosage




Oral

ALLERGIC, INFLAMMATORY AND IMMUNE DISORDERS, MALIGNANCIES: 5 to 60mg
daily depending on the condition and indication.

Parenteral

SUPPRESSION OF ALLERGIC AND INFLAMMATORY RESPONSES, BRONCHIAL ASTHMA,
SEVERE DERMATOLOGICAL RECTIONS IM: (Methylprednisolone susp 40mg,ml)
40-120mg IM weekly. (Prednisolone Acetate susp 25mg/ml) 25-100mg IM 1-2
times weekly.

IV: (Methylprednisolone sod. succinate) 10-40mg slow IV or 30mg/kg IV
infusion over 20mins. May be repeated every 4-6hrs upto 48-72hrs as reqd.
Children 0.5mg/kg/day



Intra-articular

JOINT INFLAMMATIONS: (Methylprednisolone susp 40mg.ml) 4-80mg inj
according to the size of the joint, repeated every 7-35 days. (Prednisolone
acetate susp 25mg/ml) 5-25mg inj according to size of the joint.

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Action



Typical metabolic effects of natural corticosteroids with
less salt retaining property. Synthetic analogues are primarily used for
anti-inflammatory effects. They also modify immune responses to variety
of stimuli.

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Interaction

Efficacy of prednisolone is reduced by
Aminoglutethimide, Antacids, Barbiturates, Carbamazepine, Griseofulvin,
Mitotane, Phenylbutazone, Phenytoin, Primidone and Rifampin.
Prednisolone reduces the amount of potassium in the blood. Digitalis can
cause Cardiac arrhythmias if hypokalemia occurs. Immunization should be
done very carefully. Skin test injections: Prenisolone may cause false
results in skin tests. Sodium-containing drugs: Prednisolone causes
edema, excess sodium may cause hypernatremia, hypertension, and water
retention.

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Adverse Effect & Precautions



Peptic ulceration, myopathy, steroid psychosis. On prolonged use
posterior subcapsular cataract, glaucoma. Obsteoporosis, hyperglycaemia,
increased susceptibility to infection, delayed woundhealing and causing
habitus.

Precaution has to be taken in diabetes, hypertention,
Psychological disturbances, osteoporosis, post menopausal women,
pregnancy and in chronic nephritis.Longterm use of Prednisolone can
cause cushing’s habitus, hyperglycemia, muscular weakness, increased
susceptibility to infection, delayed wound healing, and psychiatric
disturbances.

Pregnancy: Use only if clearly indicated.

Breast Feeding: Use with caution.

Man: Use with caution.

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Brands
available in market



































DEPO-MEDROL

Max
INJ 40mg/ml 2ml 65.00
HOSTACORTIN H

Hoechst Marion Roussel
TAB 5mg 10 3.35
METYPRED

Criticare
INJ 500mg VIAL 488.16
INJ 1gm VIAL 800.16
OMNACORTIL

Macleods
TAB 5mg 10 7.95
TAB 10mg 10 15.19
TAB 20mg 10 28.96
TAB 40mg 10 48.67
PREDNISAFE

Yash
TAB 5mg 5X21 107.00
SOLU-MEDROL

Max
INJ 500mg 8ml 440.00
INJ 1gm 16ml 715.00
SUCCIMEDROL

VHB
INJ 40mg VIAL 94.00
INJ 500mg VIAL 456.00
INJ 1g VIAL 753.00
UNIDROL

Unisearch
INJ 40mg 1ml 31.75
INJ 40mg/ml 2ml 48.25
WYSOLONE

Wyeth Lederle
TAB 5mg 10 5.99
TAB 10mg 10 13.20
TAB 20mg 6 16.00



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Drug Information
 

  

Pharmacokinetics

The bio-availablity of prednisolone is about 50-80 % after oral administration. It is metabolized in the liver.

Top
  

Indication & Dosage

Oral
ALLERGIC, INFLAMMATORY AND IMMUNE DISORDERS, MALIGNANCIES: 5 to 60mg daily depending on the condition and indication.
Parenteral
SUPPRESSION OF ALLERGIC AND INFLAMMATORY RESPONSES, BRONCHIAL ASTHMA, SEVERE DERMATOLOGICAL RECTIONS IM: (Methylprednisolone susp 40mg,ml) 40-120mg IM weekly. (Prednisolone Acetate susp 25mg/ml) 25-100mg IM 1-2 times weekly.
IV: (Methylprednisolone sod. succinate) 10-40mg slow IV or 30mg/kg IV infusion over 20mins. May be repeated every 4-6hrs upto 48-72hrs as reqd. Children 0.5mg/kg/day

Intra-articular
JOINT INFLAMMATIONS: (Methylprednisolone susp 40mg.ml) 4-80mg inj according to the size of the joint, repeated every 7-35 days. (Prednisolone acetate susp 25mg/ml) 5-25mg inj according to size of the joint.

Top
  

Action

Typical metabolic effects of natural corticosteroids with less salt retaining property. Synthetic analogues are primarily used for anti-inflammatory effects. They also modify immune responses to variety of stimuli.

Top
  

Interaction

Efficacy of prednisolone is reduced by Aminoglutethimide, Antacids, Barbiturates, Carbamazepine, Griseofulvin, Mitotane, Phenylbutazone, Phenytoin, Primidone and Rifampin. Prednisolone reduces the amount of potassium in the blood. Digitalis can cause Cardiac arrhythmias if hypokalemia occurs. Immunization should be done very carefully. Skin test injections: Prenisolone may cause false results in skin tests. Sodium-containing drugs: Prednisolone causes edema, excess sodium may cause hypernatremia, hypertension, and water retention.

Top
  

Adverse Effect & Precautions

Peptic ulceration, myopathy, steroid psychosis. On prolonged use posterior subcapsular cataract, glaucoma. Obsteoporosis, hyperglycaemia, increased susceptibility to infection, delayed woundhealing and causing habitus.

Precaution has to be taken in diabetes, hypertention, Psychological disturbances, osteoporosis, post menopausal women, pregnancy and in chronic nephritis.Longterm use of Prednisolone can cause cushing’s habitus, hyperglycemia, muscular weakness, increased susceptibility to infection, delayed wound healing, and psychiatric disturbances.
Pregnancy: Use only if clearly indicated.
Breast Feeding: Use with caution.
Man: Use with caution.

Top
  

DEPO-MEDROL

Max

INJ

40mg/ml

2ml

65.00

HOSTACORTIN H

Hoechst Marion Roussel

TAB

5mg

10

3.35

METYPRED

Criticare

INJ

500mg

VIAL

488.16

INJ

1gm

VIAL

800.16

OMNACORTIL

Macleods

TAB

5mg

10

7.95

TAB

10mg

10

15.19

TAB

20mg

10

28.96

TAB

40mg

10

48.67

PREDNISAFE

Yash

TAB

5mg

5X21

107.00

SOLU-MEDROL

Max

INJ

500mg

8ml

440.00

INJ

1gm

16ml

715.00

SUCCIMEDROL

VHB

INJ

40mg

VIAL

94.00

INJ

500mg

VIAL

456.00

INJ

1g

VIAL

753.00

UNIDROL

Unisearch

INJ

40mg

1ml

31.75

INJ

40mg/ml

2ml

48.25

WYSOLONE

Wyeth Lederle

TAB

5mg

10

5.99

TAB

10mg

10

13.20

TAB

20mg

6

16.00

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By |2022-07-20T16:44:59+00:00July 20, 2022|Uncategorized|Comments Off on Prednisolone

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