Drug Information

 


          














Pharmacokinetics


It is slowly but adequately absorbed from the GI tract. It is
metabolised in the liver to the active metabolite cycloguanide.

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Indication
& Dosage


Oral

CAUSAL PROPHYLAXIS OF FALCIPARUM MALARIA AND SUPRRESSION OF OTHER FORMS:
Adults: 200mg daily. For travellers treatment should sart 1 week before
travel and continue for atleast 4 weeks after leaving the endimic area.

Children:

 















Age Daily doses
Under 5 weeks 25mg
6-11 months 50mg
1-5yrs 100mg
6-11yrs 150mg
Over 12yrs 200mg
WHO recommends a dose of 3mg/kg/day
or the following schedule:
Age Daily dose
Under 1 yr 25mg
1-4 yrs 50mg
5-8 yrs 100mg
9-15yrs 150mg




 

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Action



A biguanide derivative which has to be metabolised in the
body to the active metabolite, cycloguanil. It acts by inhibiting
plasmodialdihydrofolate reductase and preventing nucleic acid synthesis.
It is active against pre-erythrocytic forms and is a slow blood
schizonicide. It is useful for preventionof malaria and not for
treatment of acute malaria.



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Interaction




Anticoagulants: Effect of warfarin possibly enhanced.

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Precautions






Nausea, vomting, diarrhoea, abdominal pain, haematuria.


Severe renal impairment.





Pregnancy: Safety not established.

Breast Feeding: Use with caution.

Man: May be used.

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Brands
available in market












LAVERAN

Unicure
TAB 100mg 10 24.81



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Drug Information
 

          

Pharmacokinetics

It is slowly but adequately absorbed from the GI tract. It is metabolised in the liver to the active metabolite cycloguanide.

Top
   

Indication & Dosage

Oral
CAUSAL PROPHYLAXIS OF FALCIPARUM MALARIA AND SUPRRESSION OF OTHER FORMS: Adults: 200mg daily. For travellers treatment should sart 1 week before travel and continue for atleast 4 weeks after leaving the endimic area.
Children:

 

Age

Daily doses

Under 5 weeks

25mg

6-11 months

50mg

1-5yrs

100mg

6-11yrs

150mg

Over 12yrs

200mg

WHO recommends a dose of 3mg/kg/day or the following schedule:

Age

Daily dose

Under 1 yr

25mg

1-4 yrs

50mg

5-8 yrs

100mg

9-15yrs

150mg


 

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Action

A biguanide derivative which has to be metabolised in the body to the active metabolite, cycloguanil. It acts by inhibiting plasmodialdihydrofolate reductase and preventing nucleic acid synthesis. It is active against pre-erythrocytic forms and is a slow blood schizonicide. It is useful for preventionof malaria and not for treatment of acute malaria.

Top
   

Interaction

Anticoagulants: Effect of warfarin possibly enhanced.

Top
   

Precautions

Nausea, vomting, diarrhoea, abdominal pain, haematuria.

Severe renal impairment.

Pregnancy: Safety not established.
Breast Feeding: Use with caution.
Man: May be used.

Top
   

LAVERAN

Unicure

TAB

100mg

10

24.81

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By |2022-07-20T16:44:59+00:00July 20, 2022|Uncategorized|Comments Off on Proguanil

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