Drug Information

 


    











Pharmacokinetics

It is a drug that is well absorbed after oral
administration,and is extensively metabolised in the liver with a little
unchanged drug appearing in the urine. It readily crosses the blood
brain barrier. Its bioavailability is 30%, which is higher via parentral
administration than via oral administration.

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Indication
& Dosage




Oral

HYPERTENSION: 10-40mg 3-4 times daily. Higher doses may be required.
Sustained release tablets 60-240mg o.d. POST-MYOCARDIAL INFARCITON:
180-240mg daily in divided doses.

HYPERTROPHIC CARDIOMYOPATHY, HYPERTROPHIC CARDIOMYOPATHY, HYPERTROPIC
SUBAORTIC STENOSIS:2-40mg 3-4 times daily.

ESSENTIAL TREMOR: 40mg b.i.d. increasing upto 240 or 320mg/day in
divided doses.

PHEOCHROMOCYTOMA: Only in association with an alpha blocker. 60mg daily
in divided doses dor 3 days before surgery, Inoperable cases 30mg daily
in divided doses. Children: Start with 0.5mg/kg b.i.d. Usual dose is
2-4mg/kg/day in divided doses. Max daily doses: 16mg/kg.

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Action



A non-selective beta blocke. Heart rate and cardiac output
are reduced. Intially peripheral resistance may be increased but in long
term it returns to pretreatment levels. Blood pressure is reduced as is
myocardial work load. IN anginal patients exercise tolerance is
increased and attacks reduced. Propranolol rduces plasma renin activity.
Propranolol exerts a quinidine-like membrane stabilising action and is
useful in cardiac arrhythmias.

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Interaction

It may increase the risk of serious allergic reaction
to these drugs: Aminophylline, Caffeine, Oxitriphylline, Theophylline:
the effects of both these drugs and beta-blockers may be reduced; in
addition, theophylline levels in the body may be increased, especially
in patients who smoke. Oral antidiabetics or Insulin: There is an
increased risk of hyperglycemia ; beta-blockers may cover up certain
symptoms of hypoglycemia such as increases in pulse rate and blood
pressure, and may make the hypoglycemia last longer. Calcium channel
blockers: bepridil, diltiazem, felodipine, flunarizine, isradipine,
nicardipine, nifedipine, nimodipine, verapamil, clonidine, guanabenz :
Effects on blood pressure may be increased. Adverse effects may occur if
clonidine, guanabenz, or a beta-blocker is stopped suddenly after use
together. Adverse cardiac effects may occur when beta-blockers are used
with calcium channel blockers. Cocaine : Cocaine may block the effects
of beta-blockers; in addition, there is an increased risk of
Hypertension, tachcardia, and possibly cardiac disorders if cocaine is
used while taking a beta-blocker. With Monoamine oxidase (MAO)
inhibitors: Taking beta-blockers within 2 weeks of taking monoamine
oxidase (MAO) inhibitors may cause severe hypertension.

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Adverse Effect & Precautions





Fatigue, tiredness, skin rash, fever, depression, nightmares, sexual
dysfunction, nausea, epigastric distress, clod extremities.
Hypoglycaemia.


 


Precaution should be taken during abrupt reduction in
dosage, pregnancy, lactation, elderly, IHD,CCF, renal or hepatic
dysfunction.

Pregnancy: Use with caution

Breast Feeding: Use with caution.

Man: May be used.

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Brands
available in market




























B.P NORM

Medley
TAB 40mg 10 5.60
BETABLOC

USV
TAB 10mg 10 3.00
BETABLOC FORTE

USV
TAB 40mg 10 9.35
BETACAP T.R.

Natco
TAB 40mg 10 14.38
TAB 80mg 10 23.96
CARDILONG

Pace(SOL)
SR-CAP 40mg 10 8.62
SR-CAP 80mg 10 14.00
CIPLAR

Cipla
TAB 10mg 10 5.50
TAB 40mg 10 13.00
TAB 80mg 10 25.00
CORBETA

Sarabhai
TAB 40mg 10 9.37
PROPAL

Sigma
TAB 10mg 12×10 46.20
TAB 40mg 12×10 104.40




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Drug Information
 

    

Pharmacokinetics

It is a drug that is well absorbed after oral administration,and is extensively metabolised in the liver with a little unchanged drug appearing in the urine. It readily crosses the blood brain barrier. Its bioavailability is 30%, which is higher via parentral administration than via oral administration.

Top
  

Indication & Dosage

Oral
HYPERTENSION: 10-40mg 3-4 times daily. Higher doses may be required. Sustained release tablets 60-240mg o.d. POST-MYOCARDIAL INFARCITON: 180-240mg daily in divided doses.
HYPERTROPHIC CARDIOMYOPATHY, HYPERTROPHIC CARDIOMYOPATHY, HYPERTROPIC SUBAORTIC STENOSIS:2-40mg 3-4 times daily.
ESSENTIAL TREMOR: 40mg b.i.d. increasing upto 240 or 320mg/day in divided doses.
PHEOCHROMOCYTOMA: Only in association with an alpha blocker. 60mg daily in divided doses dor 3 days before surgery, Inoperable cases 30mg daily in divided doses. Children: Start with 0.5mg/kg b.i.d. Usual dose is 2-4mg/kg/day in divided doses. Max daily doses: 16mg/kg.

Top
 
 

Action

A non-selective beta blocke. Heart rate and cardiac output are reduced. Intially peripheral resistance may be increased but in long term it returns to pretreatment levels. Blood pressure is reduced as is myocardial work load. IN anginal patients exercise tolerance is increased and attacks reduced. Propranolol rduces plasma renin activity. Propranolol exerts a quinidine-like membrane stabilising action and is useful in cardiac arrhythmias.

Top
  

Interaction

It may increase the risk of serious allergic reaction to these drugs: Aminophylline, Caffeine, Oxitriphylline, Theophylline: the effects of both these drugs and beta-blockers may be reduced; in addition, theophylline levels in the body may be increased, especially in patients who smoke. Oral antidiabetics or Insulin: There is an increased risk of hyperglycemia ; beta-blockers may cover up certain symptoms of hypoglycemia such as increases in pulse rate and blood pressure, and may make the hypoglycemia last longer. Calcium channel blockers: bepridil, diltiazem, felodipine, flunarizine, isradipine, nicardipine, nifedipine, nimodipine, verapamil, clonidine, guanabenz : Effects on blood pressure may be increased. Adverse effects may occur if clonidine, guanabenz, or a beta-blocker is stopped suddenly after use together. Adverse cardiac effects may occur when beta-blockers are used with calcium channel blockers. Cocaine : Cocaine may block the effects of beta-blockers; in addition, there is an increased risk of Hypertension, tachcardia, and possibly cardiac disorders if cocaine is used while taking a beta-blocker. With Monoamine oxidase (MAO) inhibitors: Taking beta-blockers within 2 weeks of taking monoamine oxidase (MAO) inhibitors may cause severe hypertension.

Top
  

Adverse Effect & Precautions

Fatigue, tiredness, skin rash, fever, depression, nightmares, sexual dysfunction, nausea, epigastric distress, clod extremities. Hypoglycaemia.
 
Precaution should be taken during abrupt reduction in dosage, pregnancy, lactation, elderly, IHD,CCF, renal or hepatic dysfunction.
Pregnancy: Use with caution
Breast Feeding: Use with caution.
Man: May be used.

Top
  

B.P NORM

Medley

TAB

40mg

10

5.60

BETABLOC

USV

TAB

10mg

10

3.00

BETABLOC FORTE

USV

TAB

40mg

10

9.35

BETACAP T.R.

Natco

TAB

40mg

10

14.38

TAB

80mg

10

23.96

CARDILONG

Pace(SOL)

SR-CAP

40mg

10

8.62

SR-CAP

80mg

10

14.00

CIPLAR

Cipla

TAB

10mg

10

5.50

TAB

40mg

10

13.00

TAB

80mg

10

25.00

CORBETA

Sarabhai

TAB

40mg

10

9.37

PROPAL

Sigma

TAB

10mg

12×10

46.20

TAB

40mg

12×10

104.40

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By |2022-07-20T16:44:58+00:00July 20, 2022|Uncategorized|Comments Off on Propranolol

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