& Dosage | Action
Adverse Effects & Precautions | Brands available in Market
Prothionamide is readily absorbed from the gastrointestinal tract and produces peak plasma concentrations about 2 hours after a dose by mouth. It is widely distributed throughout body tissues and fluids, including the CSF. Prothionamide is metabolised to the active sulphoxide and other inactive metabolites and less than 1% of a dose appears in the urine as unchanged drug.
TUBERCULOSIS. AS A SECOND LINE DRUG: Adult and children: 15-20mg/kg daily as a singel dose with a daily maxmium of 1g.
A thionamide derivative active against Mycobacterium tuberculosis. Action is similar to that of ethionamide with which it is considered interchangable Resistance develops quickly if used alone. Better tolerated than ethionamide.
Oral hypoglycaemic agent: Alters the actions of OHAs
and disturbs blood glucose levels.
INH: Decreases serum INH levels.
Adverse Effect & Precautions
Anorexia, nausea, vomiting, dysuria, arthralgia, myalgia. Elevation of plasma uric acid may lead to acute episodes of gout.
Precaution: Monitor liver function and blood uric acid regularly, history of diabetes millitus. Must be given with other antitubercular drugs.
Breast Feeding: Use with caution.
Man: May be given in reduced dose.