Drug Information


   


     












Pharmacokinetics


Quinine is completely absorbed from the GIT, and reaches an effective
plasma level in 1-3 hrs time. It can cross the placental barrier. It
gets metabolised in the Liver by hepatic enzymes and is excreted in the
urine within 24 hrs.

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Indication
& Dosage


IV

RESISTANT FALCIPARUM MALARIA:
20mg/kg IV infusion over 4 hrs repeated 8
hrly. Maintenance: 10mg/kg infused over 4 hrs every 8 hrs. Continue with
oral medication, once chlinically stable.

Oral

RESISTANT MALARIA: 600mg t.i.d for 7 days. Max 2g/day. Children:
10mg/day 8 hrly.

NOCTURNAL LEG CRAMPS: 200-600mg of quinine sulphate every night.
Discontinue after several cramp-free nights.

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Action


A cinchona alkaloid and a 4-methanol quinoline. Rapidly acting blood
schizonticide by interference with lysosomal function or nucleic acid
synthesis in the Plasmodia. No Activiy against exoerythrocytic forms. In
the skeletal muscle quinine increases the refractory period and
excitability of the myoneural junction.

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Interaction


Use of mefloquine with quinine may increase the
chance of adverse effects. Quinine can interfere with the measurement of
urinary alkaloids and Corticosteroids.Quinine increases the digitalis
toxicity.Rifampicin increases the quinine clearance.Quinine may enchance
the hypoglycaemic effect of oral antidiabetics.

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Adverse
Effects & Precautions


Patients with a
history of blackwater fever, G6PD deficiency, or purpura may have an
increased risk of hemolysis. Quinine depresses the heart and can cause
hypotension. Quinine may cause hypoglycemia. Quinine may increase muscle
weakness in patients with myasthenia gravis. CINCHONISM; large single
dose or higher doses taken for few days produce a syndrome called
cinchonism.It consists of ringing in
ears,nausea,vommiting,headache,mental confusion,vertigo,difficulty in
hearing and visual diffects.


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Brands
available in market

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Drug Information
   

     

Pharmacokinetics

Quinine is completely absorbed from the GIT, and reaches an effective plasma level in 1-3 hrs time. It can cross the placental barrier. It gets metabolised in the Liver by hepatic enzymes and is excreted in the urine within 24 hrs.

Top
   

Indication & Dosage

IV
RESISTANT FALCIPARUM MALARIA:
20mg/kg IV infusion over 4 hrs repeated 8 hrly. Maintenance: 10mg/kg infused over 4 hrs every 8 hrs. Continue with oral medication, once chlinically stable.

Oral
RESISTANT MALARIA: 600mg t.i.d for 7 days. Max 2g/day. Children: 10mg/day 8 hrly.
NOCTURNAL LEG CRAMPS: 200-600mg of quinine sulphate every night. Discontinue after several cramp-free nights.

Top
   

Action

A cinchona alkaloid and a 4-methanol quinoline. Rapidly acting blood schizonticide by interference with lysosomal function or nucleic acid synthesis in the Plasmodia. No Activiy against exoerythrocytic forms. In the skeletal muscle quinine increases the refractory period and excitability of the myoneural junction.

Top
   

Interaction

Use of mefloquine with quinine may increase the chance of adverse effects. Quinine can interfere with the measurement of urinary alkaloids and Corticosteroids.Quinine increases the digitalis toxicity.Rifampicin increases the quinine clearance.Quinine may enchance the hypoglycaemic effect of oral antidiabetics.

Top
   

Adverse Effects & Precautions

Patients with a history of blackwater fever, G6PD deficiency, or purpura may have an increased risk of hemolysis. Quinine depresses the heart and can cause hypotension. Quinine may cause hypoglycemia. Quinine may increase muscle weakness in patients with myasthenia gravis. CINCHONISM; large single dose or higher doses taken for few days produce a syndrome called cinchonism.It consists of ringing in ears,nausea,vommiting,headache,mental confusion,vertigo,difficulty in hearing and visual diffects.

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By |2022-07-20T16:42:49+00:00July 20, 2022|Uncategorized|Comments Off on Quinine

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