Drug Information

 


          












Pharmacokinetics




Ramipril is a recently introduced drug. It is rapidly absorbed after
oral administration with high bioavailability . It is highly protein
bound. It is excreted via Kidneys.

TOP


  

Indication
& Dosage





Oral

HYPERTENSION-RENAL AND NONRENAL, ALL GRADES: 2.5mg once daily may be
increased to 5mg o.d. 

CONGESTIVE HEART FAILURE:
Intially 1.25mg once daily. Increase upto 5mg
once daily.

Renal Impairment:








Creatinine clearance  
 
Dose  

Over
50ml/min  
 No change

20-50
ml/min    
 1.25mg daily

less than 20ml/min    
1.25
on alternate days max 2.5 mg


Hepatic impairment: Caution- Max daily dose in 2.5 mg
.

TOP


   

Action



A new long acting ACE inhibitor which
is metabolised into the active metabolite ramiprilat. High lipid
solubility ensures good tissue penetration especially into the heart
muscle and aortic wall. Has a higher afffinity and more persistent
binding to ACE. Provides longer duration of action and once a day
therapy. Suspine and standing blood pressures are freduced without
reflex tachycardia. Ventricular hypertrophy is reversed and renal blood
flow increased. In congestive failure pulmonary artery pressure and
pulmonary capillary wedge pressure are reduced. Cardiac function is
improved

TOP


   

Interaction

Risk of bone marrow depression when used with
immunosupressive agents. It causes hyperkalaemia with potassium sparing
diuretics. NSAID’s may block its hypotensive action.

TOP

 



Adverse Effect &
Precautions





Renal dysfunction, cough,
hyperkalaemia, angio oedema, nausea

Ramipril may cause lower birth weights.

Pregnancy: Contraindicated

Breast Feeding: Contraindicated

Man: Use with caution

TOP

 

Brands
available in market


 






















CARDACE

Hoechst Marion Roussel

CAPS

1.25mg

10

24.50

CAPS

2.5mg

10

42.50

CAPS

5mg

10

73.50

CORPRIL

Solus

CAPS

1.25mg

10

24.00

CAPS

2.5mg

10

41.50

CAPS

5mg

10

72.00

RAMACE

Astra-IDL

CAPS

1.25mg

10

25.50

CAPS

2.5mg

10

44.00

CAPS

5mg

10

76.00

RAMVAS

Indipharma

CAPS

1.25mg

10

20.00

CAPS

2.5mg

10

36.00

CAPS

5mg

10

67.00



TOP



 

                                                                                 






     

 
Drug Information
 

          

Pharmacokinetics

Ramipril is a recently introduced drug. It is rapidly absorbed after oral administration with high bioavailability . It is highly protein bound. It is excreted via Kidneys.

TOP
  

Indication & Dosage

Oral
HYPERTENSION-RENAL AND NONRENAL, ALL GRADES: 2.5mg once daily may be increased to 5mg o.d. 
CONGESTIVE HEART FAILURE:
Intially 1.25mg once daily. Increase upto 5mg once daily.
Renal Impairment:

Creatinine clearance  

 

Dose

 

Over 50ml/min  

 No change

20-50 ml/min    

 1.25mg daily

less than 20ml/min    

1.25 on alternate days max 2.5 mg

Hepatic impairment: Caution- Max daily dose in 2.5 mg.

TOP
   

Action

A new long acting ACE inhibitor which is metabolised into the active metabolite ramiprilat. High lipid solubility ensures good tissue penetration especially into the heart muscle and aortic wall. Has a higher afffinity and more persistent binding to ACE. Provides longer duration of action and once a day therapy. Suspine and standing blood pressures are freduced without reflex tachycardia. Ventricular hypertrophy is reversed and renal blood flow increased. In congestive failure pulmonary artery pressure and pulmonary capillary wedge pressure are reduced. Cardiac function is improved

TOP
   

Interaction

Risk of bone marrow depression when used with immunosupressive agents. It causes hyperkalaemia with potassium sparing diuretics. NSAID’s may block its hypotensive action.

TOP

 

Adverse Effect & Precautions

Renal dysfunction, cough, hyperkalaemia, angio oedema, nausea

Ramipril may cause lower birth weights.
Pregnancy: Contraindicated
Breast Feeding: Contraindicated
Man: Use with caution

TOP

 

CARDACE

Hoechst Marion Roussel

CAPS

1.25mg

10

24.50

CAPS

2.5mg

10

42.50

CAPS

5mg

10

73.50

CORPRIL

Solus

CAPS

1.25mg

10

24.00

CAPS

2.5mg

10

41.50

CAPS

5mg

10

72.00

RAMACE

Astra-IDL

CAPS

1.25mg

10

25.50

CAPS

2.5mg

10

44.00

CAPS

5mg

10

76.00

RAMVAS

Indipharma

CAPS

1.25mg

10

20.00

CAPS

2.5mg

10

36.00

CAPS

5mg

10

67.00

TOP

 

                                                                                 

By |2022-07-20T16:42:48+00:00July 20, 2022|Uncategorized|Comments Off on Ramipril

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