Drug Information

   


    














 

Pharmacokinetics.

 

It is well absorbed orally, but its bioavailablity is
reduced when given with antacids. Theraupetic effect lasts for about 4-7
hours. It is excreted mainly in the urine, within 24 hours mainly as
unchanged drug. It can cross the placental barrier and is secreted in
milk.

 

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Indication
& Dosage




Oral


DUODENAL ULCER:
150mg b.i.d or 300mg once daily. After 4-8 wks 150mg at
bedtime.


BENIGN GASTRIC ULCER:
As for duodenal ulcer.


REFLUX OESOPHAGITIS:
150mg b.i.d for upto 8 weeks.


ZOLLINGER-ELLISON SYNDROME:
150mg 2 or 3 times daily increasing upto max
of 6g/day.


PREVENTION OF RECURRENT BLEEDING IN STRESS ULCERS:
150mg b.i.d.


PREVENTION OF ACID ASPIRATION DURING GENERAL ANAESTHESIA:
150mg orally 2
hrs before induction. May be repeated every 6 hrs as required Children:
50-150mg daily have been given.



IV, IM



PATHOLOGICAL HYPERSECRETORY CONDITIONS AND INTRACTABLE ULCERS IN
HOSPITALISED PATIENTS:
50-100mg every 6hrs.

Note: renal impairment: when creatinine clearance is less than 50ml/min
150mg every 24hrs.

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Action



Block histamine H2 receptors in the stomach and prevents
histamine-mediated gastric acid secretion. It has no anticholinergic
action. Acid secretion in response to petagastrin, bethanechol and food
is also inhibited.

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Interaction

Aminophylline, Anticoagulants, Caffeine, Metoprolol,
Oxtriphylline, Phenytoin, Propranolol, Theophylline, Tricyclic
antidepressants (amitriptyline, amoxapine, clomipramine, desipramine,
doxepin, imipramine, nortriptyline, protriptyline ) : these drugs when
used with ranitidine have been shown to potentiate the effects of
ranitidine. Itraconazole, Ketoconazole : H2-blockers may decrease the
effects of itraconazole or ketoconazole, hence H2-blockers should be
taken at least 2 hours after these drugs.


 

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Adverse Effect & Precautions




Dizziness, confusion, constipation,
skin rash, headache, leucopenia and thrombocytopenia.

Allergies : Allergies to Ranitidine may occur.
Pregnancy : H2-blockers have not yet been fully studied in pregnant
women. Breast-feeding : Ranitidine passes into the breast milk and may
cause adverse effects, such as decreased amount of stomach acid and
increased excitement, in the nursing baby. . Adults : Confusion and
dizziness may be especially likely to occur in elderly patients, who are
usually more sensitive than younger patients.

Pregnancy: Safety Not established

Breast Feeding: Use with caution

Man: May be used.

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Brands
available in market


 




























































































ACILOC

Cadila Pharma
TAB 150mg 10 10.06
TAB 300mg 10 18.76
INJ 50mg/2ml 2ml 2.96
ADVENE

Knoll Pharma
TAB 150mg 10 9.43
TAB 300mg 10 36.71
ALPRODINE

Remedies(india)
TAB 150mg 10 7.68
CONSEC

Jagsonpal
TAB 150mg 10 7.21
DIN

Mapra
TAB 150mg 10 7.16
GIRAN

Astra-IDL
TAB 150mg 10 7.21
HISTAC

Ranbaxy
TAB 150mg 10 9.46
TAB 300mg 10 17.41
INJ 50mg/2ml 2ml 3.02
HISTAC-EVT

Ranbaxy
EFF-TAB 150mg 2 6.00
KAMTAC

Kamron
TAB 150mg 10 7.16
TAB 300mg 10 12.83
LYDIN

Lyka
TAB 150mg 10 7.16
NILCER

Khandelwal
TAB 150mg 10 19.07
R-LOC

Cadila Healthcare
TAB 150mg 10 7.66
INJ 50mg/ml 2ml 13.77
TAB 75mg 10 5.58
RAN X

Unisearch
TAB 150mg 10 19.14
RANIAL

Albert david
TAB 150MG 10 9.13
TAB 300MG 10 17.41
RANITIDINE

Glaxo
INJ 50mg 2ml 4.62
RANITIDINE INJ

Alidac
INJ 50mg 5x2ml 12.64
RANITIDINE-AD

Albert david
TAB 150mg 10 8.18
RANITIN

Torrent
TAB 150mg 10 10.07
TAB 300mg 10 18.53
INJ 50mg/2ml 2ml 2.22
RANNET

PCI
TAB 150mg 10 10.09
TAB 300mg 10 18.57
RANTAC

Unique
TAB 150mg 10 7.66
TAB 300mg 10 13.64
INJ 50mg/2ml 5x2ml 13.35
RDIN

Helios
TAB 150mg 10 7.12
TAB 300mg 10 12.75
INJ 25mg/2ml 2ml 2.31
RENITAB

Micro Lab
TAB 300MG 10 12.74
TAB 150mg 10 7.11
RIDCER

Gufic
TAB 150mg 10 10.09
TAB 300mg 10 18.57
INJ 50mg/2ml 2ml 2.30
RINTID

Kopran
TAB 150MG 10 197.36
ULCITAB

Themis Pharma
TAB 150mg 10 8.74
TAB 300mg 10 16.10
ULFAST

Sun Pharma
TAB 150mg 10×10 71.60
TAB 300mg 10×10 138.30
ULTIDIN

Malladi Drugs
TAB 150mg 10 12.00
TAB 300mg 10 37.97
ZINETAC

Glaxo
TAB 150mg 10 9.45
TAB 300mg 10 17.39
INJ 25mg/2ml 2ml 2.41
ZORAN

DR. Reddy’s
TAB 150mg 10 7.66
ZYNOL

Micro Nova
TAB 150mg 10 7.11
TAB 75mg 10 6.00
TAB 300mg 10 13.53









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Drug Information
   

    

 
Pharmacokinetics.
 
It is well absorbed orally, but its bioavailablity is reduced when given with antacids. Theraupetic effect lasts for about 4-7 hours. It is excreted mainly in the urine, within 24 hours mainly as unchanged drug. It can cross the placental barrier and is secreted in milk.
 

TOP

    

Indication & Dosage

Oral
DUODENAL ULCER: 150mg b.i.d or 300mg once daily. After 4-8 wks 150mg at bedtime.
BENIGN GASTRIC ULCER: As for duodenal ulcer.
REFLUX OESOPHAGITIS: 150mg b.i.d for upto 8 weeks.
ZOLLINGER-ELLISON SYNDROME: 150mg 2 or 3 times daily increasing upto max of 6g/day.
PREVENTION OF RECURRENT BLEEDING IN STRESS ULCERS: 150mg b.i.d.
PREVENTION OF ACID ASPIRATION DURING GENERAL ANAESTHESIA: 150mg orally 2 hrs before induction. May be repeated every 6 hrs as required Children: 50-150mg daily have been given.

IV, IM
PATHOLOGICAL HYPERSECRETORY CONDITIONS AND INTRACTABLE ULCERS IN HOSPITALISED PATIENTS: 50-100mg every 6hrs.
Note: renal impairment: when creatinine clearance is less than 50ml/min 150mg every 24hrs.

TOP

       

Action

Block histamine H2 receptors in the stomach and prevents histamine-mediated gastric acid secretion. It has no anticholinergic action. Acid secretion in response to petagastrin, bethanechol and food is also inhibited.

TOP

 

Interaction

Aminophylline, Anticoagulants, Caffeine, Metoprolol, Oxtriphylline, Phenytoin, Propranolol, Theophylline, Tricyclic antidepressants (amitriptyline, amoxapine, clomipramine, desipramine, doxepin, imipramine, nortriptyline, protriptyline ) : these drugs when used with ranitidine have been shown to potentiate the effects of ranitidine. Itraconazole, Ketoconazole : H2-blockers may decrease the effects of itraconazole or ketoconazole, hence H2-blockers should be taken at least 2 hours after these drugs.
 

TOP

 

Adverse Effect & Precautions

Dizziness, confusion, constipation, skin rash, headache, leucopenia and thrombocytopenia.

Allergies : Allergies to Ranitidine may occur. Pregnancy : H2-blockers have not yet been fully studied in pregnant women. Breast-feeding : Ranitidine passes into the breast milk and may cause adverse effects, such as decreased amount of stomach acid and increased excitement, in the nursing baby. . Adults : Confusion and dizziness may be especially likely to occur in elderly patients, who are usually more sensitive than younger patients.
Pregnancy: Safety Not established
Breast Feeding: Use with caution
Man: May be used.

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ACILOC

Cadila Pharma

TAB

150mg

10

10.06

TAB

300mg

10

18.76

INJ

50mg/2ml

2ml

2.96

ADVENE

Knoll Pharma

TAB

150mg

10

9.43

TAB

300mg

10

36.71

ALPRODINE

Remedies(india)

TAB

150mg

10

7.68

CONSEC

Jagsonpal

TAB

150mg

10

7.21

DIN

Mapra

TAB

150mg

10

7.16

GIRAN

Astra-IDL

TAB

150mg

10

7.21

HISTAC

Ranbaxy

TAB

150mg

10

9.46

TAB

300mg

10

17.41

INJ

50mg/2ml

2ml

3.02

HISTAC-EVT

Ranbaxy

EFF-TAB

150mg

2

6.00

KAMTAC

Kamron

TAB

150mg

10

7.16

TAB

300mg

10

12.83

LYDIN

Lyka

TAB

150mg

10

7.16

NILCER

Khandelwal

TAB

150mg

10

19.07

R-LOC

Cadila Healthcare

TAB

150mg

10

7.66

INJ

50mg/ml

2ml

13.77

TAB

75mg

10

5.58

RAN X

Unisearch

TAB

150mg

10

19.14

RANIAL

Albert david

TAB

150MG

10

9.13

TAB

300MG

10

17.41

RANITIDINE

Glaxo

INJ

50mg

2ml

4.62

RANITIDINE INJ

Alidac

INJ

50mg

5x2ml

12.64

RANITIDINE-AD

Albert david

TAB

150mg

10

8.18

RANITIN

Torrent

TAB

150mg

10

10.07

TAB

300mg

10

18.53

INJ

50mg/2ml

2ml

2.22

RANNET

PCI

TAB

150mg

10

10.09

TAB

300mg

10

18.57

RANTAC

Unique

TAB

150mg

10

7.66

TAB

300mg

10

13.64

INJ

50mg/2ml

5x2ml

13.35

RDIN

Helios

TAB

150mg

10

7.12

TAB

300mg

10

12.75

INJ

25mg/2ml

2ml

2.31

RENITAB

Micro Lab

TAB

300MG

10

12.74

TAB

150mg

10

7.11

RIDCER

Gufic

TAB

150mg

10

10.09

TAB

300mg

10

18.57

INJ

50mg/2ml

2ml

2.30

RINTID

Kopran

TAB

150MG

10

197.36

ULCITAB

Themis Pharma

TAB

150mg

10

8.74

TAB

300mg

10

16.10

ULFAST

Sun Pharma

TAB

150mg

10×10

71.60

TAB

300mg

10×10

138.30

ULTIDIN

Malladi Drugs

TAB

150mg

10

12.00

TAB

300mg

10

37.97

ZINETAC

Glaxo

TAB

150mg

10

9.45

TAB

300mg

10

17.39

INJ

25mg/2ml

2ml

2.41

ZORAN

DR. Reddy’s

TAB

150mg

10

7.66

ZYNOL

Micro Nova

TAB

150mg

10

7.11

TAB

75mg

10

6.00

TAB

300mg

10

13.53



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By |2022-07-20T16:44:57+00:00July 20, 2022|Uncategorized|Comments Off on Ranitidine

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