Drug Information

    


    
   















Pharmacokinetics

Risperidone is
readily absorbed after oral doses, peak plasma concentrations being
reached within 1 to 2 hours. It is extensively metabolised in the liver
by hydroxylation to its main active metabolite, 9-hydroxyrisperidone;
oxidative N-dealkylation is a minor metabolic pathway. Hydroxylation is
mediated by the cytochrome P450 isozyme CYP2D6 and is the subject of
genetic polymorphism. Excretion is mainly in the urine and to a lesser
extent, in the faeces. Risperidone and 9-hydroxyrisperidone are about
88% and 77% bound to plasma proteins, respectively.

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Indication
& Dosage





Oral

ACUTE AND CHRONIC PSYCHOSES: Adults: 2mg in 1 or 2 divided doses on
1st day then 4mg in 1-2 divided doses on 2nd day, then 6mg in 1-2
divided doses on 3rd day (slower dose titration preferrred in some
patients for better compliance). Usual dose range 4-mg daily. Doses
above 10mg daily. Only if benefit outweighs risk (Max: 16mg daily)
Elderly (or in hepatic or in renal impairment): 0.5mg b.i.d increased to
1-2mg b.i.d. Children (Under 15yrs): Not recommended

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Action



It is an atypical antipsychotic; it has been proposed that this
drug’s antipsychotic activity is mediated through a combination of
dopamine (D2) and serotonin (5HT2) receptor antagonism. It is less
likely to cause exrapyramidal effects than conventional antipsychotics.

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Interaction

Levodopa : Efficacy of levodopa and
dopamine agonists reduced.

Carbamazepine : Chronic and administration of carbamazepine may decrease
it’s efficacy. 

Ciozapine : Chronic administration of clozapine may enhance it’s
efficacy.

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Adverse Effect &
Precautions


 

Insomnia, nausea, somnolence,
agitation, anxiety, extrapyramidal symptoms, headache, dizziness,
anorexia, vomiting, rhinitis, palpitation, menorrhagia and dry vagina,
rarely erectile dysfunction may be seen



Monitor for NMS (Neuroleptic Malignant Sydrome) & tradive dyskinesia,
orthostatic hypotension, history of seizures, patients likely to be
exposed ot extreme heat & those with concomitant systemic illnesses,
avoid alcohol, adivice patients to inform their physician if thery are
planning to take or are taking any other drug. Risperidone’s extra
pyramidal side effects are limited if low doses are used.



Pregnancy : Safety not
established

Brest Feeding : Use with Caution.

Men : May be given in reduced dose.

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Brands
available in market

































































REGRACE

La pharma
TAB 1mg 10 7.50
TAB 2mg 10 12.90
TAB 3mg 10 20.50
TAB 4mg 10 26.00
RESPIDON

Torrent
TAB 1mg 10 18.55
TAB 2mg 10 35.29
TAB 3mg 10 48.00
TAB 4mg 10 58.00
RISDONE

Intas
TAB 1mg 10 5.60
TAB 2mg 10 10.40
TAB 3mg 10 15.20
TAB 4mg 10 20.00
Susp 1mg/ml 60ml 90.50
RISPERDAL

Ethnor
F-C TAB 1mg 10 127.35
F-C TAB 2mg 10 254.70
F-C TAB 3mg 10 382.05
F-C TAB 4mg 10 509.40
SOLN 1mg/ml 100ml 0.00
F-C TAB 1mg 20 0.00
F-C TAB 2mg 20 0.00
F-C TAB 3mg 20 0.00
F-C TAB 4mg 20 0.00
F-C TAB 1mg 60 0.00
F-C TAB 2mg 60 0.00
F-C TAB 3mg 60 0.00
F-C TAB 4mg 60 0.00
RISPID

Panacea
TAB 1mg 10×10 7.40
TAB 2mg 10×10 12.90
TAB 3mg 10×10 20.10
TAB 4mg 10×10 26.00
LIQUID 1mg/ml 50ml 141.00
ROZIDAL

Solus
TAB 1mg 10 17.50
TAB 2mg 10 34.00
TAB 3mg 10 52.00
TAB 4mg 10 70.00
SIZODON

Sun Pharma
TAB 1mg 10 9.00
TAB 2mg 10 15.00
TAB 3mg 10 22.50
TAB 4mg 10 29.50
SIZOMAX

Sertec
TAB 1mg 10 12.08
TAB 2mg 10 20.13
TAB 3mg 10 28.18
TAB 4mg 10 36.23
ZISPER

Unisearch
TAB 1mg 10 7.00
TAB 2mg 10 12.50
TAB 3mg 10 19.00



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Drug Information
    

        

Pharmacokinetics

Risperidone is readily absorbed after oral doses, peak plasma concentrations being reached within 1 to 2 hours. It is extensively metabolised in the liver by hydroxylation to its main active metabolite, 9-hydroxyrisperidone; oxidative N-dealkylation is a minor metabolic pathway. Hydroxylation is mediated by the cytochrome P450 isozyme CYP2D6 and is the subject of genetic polymorphism. Excretion is mainly in the urine and to a lesser extent, in the faeces. Risperidone and 9-hydroxyrisperidone are about 88% and 77% bound to plasma proteins, respectively.

Top
  

Indication & Dosage

Oral
ACUTE AND CHRONIC PSYCHOSES: Adults: 2mg in 1 or 2 divided doses on 1st day then 4mg in 1-2 divided doses on 2nd day, then 6mg in 1-2 divided doses on 3rd day (slower dose titration preferrred in some patients for better compliance). Usual dose range 4-mg daily. Doses above 10mg daily. Only if benefit outweighs risk (Max: 16mg daily) Elderly (or in hepatic or in renal impairment): 0.5mg b.i.d increased to 1-2mg b.i.d. Children (Under 15yrs): Not recommended

Top
  

Action

It is an atypical antipsychotic; it has been proposed that this drug’s antipsychotic activity is mediated through a combination of dopamine (D2) and serotonin (5HT2) receptor antagonism. It is less likely to cause exrapyramidal effects than conventional antipsychotics.

Top
  

Interaction
Levodopa : Efficacy of levodopa and dopamine agonists reduced.
Carbamazepine : Chronic and administration of carbamazepine may decrease it’s efficacy. 
Ciozapine : Chronic administration of clozapine may enhance it’s efficacy.

Top
  

Adverse Effect & Precautions
 
Insomnia, nausea, somnolence, agitation, anxiety, extrapyramidal symptoms, headache, dizziness, anorexia, vomiting, rhinitis, palpitation, menorrhagia and dry vagina, rarely erectile dysfunction may be seen

Monitor for NMS (Neuroleptic Malignant Sydrome) & tradive dyskinesia, orthostatic hypotension, history of seizures, patients likely to be exposed ot extreme heat & those with concomitant systemic illnesses, avoid alcohol, adivice patients to inform their physician if thery are planning to take or are taking any other drug. Risperidone’s extra pyramidal side effects are limited if low doses are used.

Pregnancy : Safety not established
Brest Feeding : Use with Caution.
Men : May be given in reduced dose.

Top
  

REGRACE

La pharma

TAB

1mg

10

7.50

TAB

2mg

10

12.90

TAB

3mg

10

20.50

TAB

4mg

10

26.00

RESPIDON

Torrent

TAB

1mg

10

18.55

TAB

2mg

10

35.29

TAB

3mg

10

48.00

TAB

4mg

10

58.00

RISDONE

Intas

TAB

1mg

10

5.60

TAB

2mg

10

10.40

TAB

3mg

10

15.20

TAB

4mg

10

20.00

Susp

1mg/ml

60ml

90.50

RISPERDAL

Ethnor

F-C TAB

1mg

10

127.35

F-C TAB

2mg

10

254.70

F-C TAB

3mg

10

382.05

F-C TAB

4mg

10

509.40

SOLN

1mg/ml

100ml

0.00

F-C TAB

1mg

20

0.00

F-C TAB

2mg

20

0.00

F-C TAB

3mg

20

0.00

F-C TAB

4mg

20

0.00

F-C TAB

1mg

60

0.00

F-C TAB

2mg

60

0.00

F-C TAB

3mg

60

0.00

F-C TAB

4mg

60

0.00

RISPID

Panacea

TAB

1mg

10×10

7.40

TAB

2mg

10×10

12.90

TAB

3mg

10×10

20.10

TAB

4mg

10×10

26.00

LIQUID

1mg/ml

50ml

141.00

ROZIDAL

Solus

TAB

1mg

10

17.50

TAB

2mg

10

34.00

TAB

3mg

10

52.00

TAB

4mg

10

70.00

SIZODON

Sun Pharma

TAB

1mg

10

9.00

TAB

2mg

10

15.00

TAB

3mg

10

22.50

TAB

4mg

10

29.50

SIZOMAX

Sertec

TAB

1mg

10

12.08

TAB

2mg

10

20.13

TAB

3mg

10

28.18

TAB

4mg

10

36.23

ZISPER

Unisearch

TAB

1mg

10

7.00

TAB

2mg

10

12.50

TAB

3mg

10

19.00

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By |2022-07-20T16:41:34+00:00July 20, 2022|Uncategorized|Comments Off on Risperidone

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