Drug Information

 



          












Pharmacokinetics



Ritodrine is rapidly absorbed from the gastrointestinal tract but is
subject to fairly extensive first-pass metabolism; about 30% of an oral
dose is bioavailable. It is metabolised in the liver primarily by
conjugation with glucuronic acid or sulphate and excreted in urine as
unchanged drug and metabolites. About 70 to 90% of a dose is reported to
be excreted in the urine within 10 to 12 hours. It crosses the placenta.

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Indication
& Dosage


 


IV

MANAGEMENT OF UNCOMPLICATED PREMATURE LABOUR: IV infusion initially
0.05mg/min. Incrase by 0.05mg/min every 10-15 min. Maintain for 12-48
hrs.



IM

10mg every 4-6 hrs.

Oral

Oral therapy is started 30-60mins before terminationof IV infusion with
10mg every 2-6 hrs. Max oral dose 120 mg daily.

ACUTE FETAL DISTRESS: 0.05mg/min by IV infusion rapidly increasing until
uterine activity is suppressed or material heart rate reaches 140/min.

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Action

 


A selective beta2-adrenoceptor agonist with its main action
on uterus causing relaxation. It reduces the intensity and frequency of
contracitions. Heart rate i increased while diastolic pressure is
reduced. May cause bronchial relaxation but this is not clinically
significant in it usage.

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Interaction


 

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Adverse Effect
& Precautions




With oral administration: Tachycardia, tremor, palpitation, nausea,
jitteriness, rash, caridac arrhytmias and hepatitis.

With I.V. administration: Tachycardia, Palpitation, nausea, pulmonary
oedema, vomiting, headache, erythema. Nervouseness, anxiety or emotional
upset. rarely anaphylactic shock, cardiac arrhythmias, diarrhoea,
constipation, bloating, lactic acidosis, glycosuria, chills, sweating
& hepatitis



Special Precautions : Prologed use, renal or hepatic impairment,
diabetes mellitus, tachyarrhyth-mias, monitor electrolytes, fluids,
fetal condition, cardiac function.

Pregnancy : Contraindicated (<24 Weeks)

Breast Feeding: NA:

Man: NA

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Brands
available in market


 











YUTOPAR

Duphar-Interfran
TAB 100mg 10 95.62
INJ 50mg/5ml 4x5ml 382.44



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Drug Information
 

          

Pharmacokinetics

Ritodrine is rapidly absorbed from the gastrointestinal tract but is subject to fairly extensive first-pass metabolism; about 30% of an oral dose is bioavailable. It is metabolised in the liver primarily by conjugation with glucuronic acid or sulphate and excreted in urine as unchanged drug and metabolites. About 70 to 90% of a dose is reported to be excreted in the urine within 10 to 12 hours. It crosses the placenta.

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Indication & Dosage
 
IV
MANAGEMENT OF UNCOMPLICATED PREMATURE LABOUR: IV infusion initially 0.05mg/min. Incrase by 0.05mg/min every 10-15 min. Maintain for 12-48 hrs.

IM
10mg every 4-6 hrs.

Oral
Oral therapy is started 30-60mins before terminationof IV infusion with 10mg every 2-6 hrs. Max oral dose 120 mg daily.
ACUTE FETAL DISTRESS: 0.05mg/min by IV infusion rapidly increasing until uterine activity is suppressed or material heart rate reaches 140/min.

TOP
    

Action
 
A selective beta2-adrenoceptor agonist with its main action on uterus causing relaxation. It reduces the intensity and frequency of contracitions. Heart rate i increased while diastolic pressure is reduced. May cause bronchial relaxation but this is not clinically significant in it usage.

TOP
    

Interaction
 

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Adverse Effect & Precautions

With oral administration: Tachycardia, tremor, palpitation, nausea, jitteriness, rash, caridac arrhytmias and hepatitis.
With I.V. administration: Tachycardia, Palpitation, nausea, pulmonary oedema, vomiting, headache, erythema. Nervouseness, anxiety or emotional upset. rarely anaphylactic shock, cardiac arrhythmias, diarrhoea, constipation, bloating, lactic acidosis, glycosuria, chills, sweating & hepatitis

Special Precautions : Prologed use, renal or hepatic impairment, diabetes mellitus, tachyarrhyth-mias, monitor electrolytes, fluids, fetal condition, cardiac function.
Pregnancy : Contraindicated (<24 Weeks)
Breast Feeding: NA:
Man: NA

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YUTOPAR

Duphar-Interfran

TAB

100mg

10

95.62

INJ

50mg/5ml

4x5ml

382.44

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By |2022-07-20T16:44:55+00:00July 20, 2022|Uncategorized|Comments Off on Ritodrine

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