Drug Information

 


          












Pharmacokinetics


Following oral administration
roxithromycin is absorbed, with a bioavailability of about 50%. Peak
plasma concentrations of about 6 to 8 micrograms per mL occur around 2
hours after a single dose of 150 mg. The mean peak plasma concentration
at steady state after a dose of 150 mg twice daily is 9.3 micrograms per
mL. Absorption is reduced when taken after, but not before, a meal. It
is widely distributed in tissues and body fluids. It is reported to be
about 96% bound to plasma protein (mainly alpha(1)-acid glycoprotein) at
trough concentrations, but binding is saturable, and only about 86% is
bound at usual peak concentrations. Small amounts of roxithromycin are
metabolised in the liver, and the majority of a dose is excreted in the
faeces as unchanged drug and metabolites; about 7 to 12% is excreted in
urine, and up to 15% via the lungs. The elimination half-life is
reported to range between about 8 and 13 hours, but may be more
prolonged in patients with impaired hepatic or renal function and in
children.

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Indication
& Dosage


 



Oral

UTI, RTI, ENT INFECTIONS, SKIN AND SOFT TISSUE INFECTIONS, OTHER
INFECTIONS CAUSED BY SUSCEPTIBLE ORGANISMS: Adult: 150-300mg b.i.d 30
min before meals for 7 days. Children: 2.5-5mg/kg every 12hrs for 7
days. Elderly: No change required. Renal damage: No Change. cirrhosis:
150mg once daily.

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Action



Can be rapidly bactericidal depending on concentration and
sensitivity. Antimicrobial spectrum similar to that of erythromycin but
roxithromycin has better cellular penetration and can enhance host
defence mechanisms. Susceptible pathogens include Staph. aureus, Staph.
epedermidis, strep. agalacteae (Group B, Group C), Strep.pyogenes (Group
A), Step.pneuomoniae, Corynebacterium diptheriae, Listeria monocytogenes,
N.gonorrhoeae, H.influenzae, H.ducreyi, Gardnerella vaginalis, Moraxella
catarrhalis, legionella pneumoniae, Baceroides spp, Chlamydia,
Mycoplasma, Ureaplasma, etc.

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Interaction

 


Digoxin : Increases absorption.

Midazolam : Increases its half-life

Terfenadine : Serum levels elevated leading to ventricular arrhythmias.

Disopyramide : Displaced from its protein bound sites.

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Precautions


 


Special Precautions : Hepatic dysfunction.

Pregnancy : Safety not Established  

Brest Feeding : Use with Caution.

Men : May be used. 

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Brands
available in market


 



























































































AUROX 150

Aurbindo
TAB 150mg 10 95.00
AUROX-KID

Aurbindo
DISP-TAB 50mg 10 38.50
BD-ROX

Panacea
TAB 150mg 5×10 105.00
BIOROX

Biochem
TAB 150mg 10 68.50
DT(KID) 50mg 10 35.22
DEROX

DWD
Pharma
TABS 150mg 10 75.00
LIQUID 50mg/5ml 30ml 35.00
DEROX KID

DWD
Pharma
DISP-TAB 50mg 10 35.00
HYCIN

Saga
Labs
TAB 150mg 10 126.00
DT-TAB 50mg 10 49.50
ODIROX

Protec
TAB 150mg 10 97.50
TAB 300mg 5 95.00
ROKCIN

Plethico
F-C TAB 150mg 10 95.88
F-C TAB 50mg 10 38.86
ROXACE

Ind-Chemie
TAB 150mg 10 85.00
DISP-TAB 50mg 10 40.00
ROXEM

Arsto
TAB 150mg 10 95.61
KID-TAB 50mg 10 42.27
SUSP 50mg/ml 10 35.23
ROXEPTIN

IPCA
TAB 150mg 10 90.00
ROXETOMIN

Sun
Pharma
KID-TAB 50mg 10×10 330.00
TAB 150mg 10×10 690.00
ROXIBEST

Blue
cross
TAB 150mg 10 70.00
ROXIBEST-P

Blue
Cross
TAB 50mg 10 33.00
ROXIBID

Zeita
TAB 150mg 4 58.00
ROXID

Alembic
TAB 150mg 10 110.20
TAB 300mg 4 86.05
KID-TAB 50mg 10 48.05
LIQUID 50mg/ml 30ml 38.25
ROXILIN

Lincoin
TAB 150mg 10 99.00
TAB 50mg 10 45.50
ROXIMOL

Torrent
TAB 150mg 10 109.00
TAB 50mg 10 40.00
REOXISARA

Sarabhai
TAB 150mg 10 90.02
TAB 300mg 10 165.64
DISP TAB 50mg 10 33.12
SUSP 50mg/5ml 10 38.12
ROXITEM

Kramer
TAB 150mg 6 56.00
KID-TAB 50mg 10 38.90
ROXITHRO

Rexcel
TAB 150mg 10 108.00
TAB 300mg 5 73.75
KID-TAB 50mg 10 47.00
ROXITIS

Medley
TAB 50mg 10 44.70
TAB 150mg 10 94.80
ROXYROL

Concept
TAB 150mg 4 36.75
KID-DIS 50mg 10 38.28
RULIDE

Roussel
K-TAB 50mg 10 46.75
TAB 150mg 10 112.50
TAB 300mg 5 107.38
THROX

Alkem
TAB 150mg 10 83.00
TAB 50mg 10 37.00
TROXY

Aglowmed
TAB 150mg 10 79.00
TRUROX 150mg 10 Menarini
TAB

100.00
UNOROX 150mg 10 Centaur
TABS

68.95




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Drug Information
 

          

Pharmacokinetics

Following oral administration roxithromycin is absorbed, with a bioavailability of about 50%. Peak plasma concentrations of about 6 to 8 micrograms per mL occur around 2 hours after a single dose of 150 mg. The mean peak plasma concentration at steady state after a dose of 150 mg twice daily is 9.3 micrograms per mL. Absorption is reduced when taken after, but not before, a meal. It is widely distributed in tissues and body fluids. It is reported to be about 96% bound to plasma protein (mainly alpha(1)-acid glycoprotein) at trough concentrations, but binding is saturable, and only about 86% is bound at usual peak concentrations. Small amounts of roxithromycin are metabolised in the liver, and the majority of a dose is excreted in the faeces as unchanged drug and metabolites; about 7 to 12% is excreted in urine, and up to 15% via the lungs. The elimination half-life is reported to range between about 8 and 13 hours, but may be more prolonged in patients with impaired hepatic or renal function and in children.

TOP
  

Indication & Dosage
 
Oral
UTI, RTI, ENT INFECTIONS, SKIN AND SOFT TISSUE INFECTIONS, OTHER INFECTIONS CAUSED BY SUSCEPTIBLE ORGANISMS: Adult: 150-300mg b.i.d 30 min before meals for 7 days. Children: 2.5-5mg/kg every 12hrs for 7 days. Elderly: No change required. Renal damage: No Change. cirrhosis: 150mg once daily.

TOP
  

Action

Can be rapidly bactericidal depending on concentration and sensitivity. Antimicrobial spectrum similar to that of erythromycin but roxithromycin has better cellular penetration and can enhance host defence mechanisms. Susceptible pathogens include Staph. aureus, Staph. epedermidis, strep. agalacteae (Group B, Group C), Strep.pyogenes (Group A), Step.pneuomoniae, Corynebacterium diptheriae, Listeria monocytogenes, N.gonorrhoeae, H.influenzae, H.ducreyi, Gardnerella vaginalis, Moraxella catarrhalis, legionella pneumoniae, Baceroides spp, Chlamydia, Mycoplasma, Ureaplasma, etc.

TOP
  

Interaction
 
Digoxin : Increases absorption.
Midazolam : Increases its half-life
Terfenadine : Serum levels elevated leading to ventricular arrhythmias.
Disopyramide : Displaced from its protein bound sites.

TOP
  

Precautions
 
Special Precautions : Hepatic dysfunction.
Pregnancy : Safety not Established  
Brest Feeding : Use with Caution.
Men : May be used. 

TOP
   

AUROX 150

Aurbindo

TAB

150mg

10

95.00

AUROX-KID

Aurbindo

DISP-TAB

50mg

10

38.50

BD-ROX

Panacea

TAB

150mg

5×10

105.00

BIOROX

Biochem

TAB

150mg

10

68.50

DT(KID)

50mg

10

35.22

DEROX

DWD Pharma

TABS

150mg

10

75.00

LIQUID

50mg/5ml

30ml

35.00

DEROX KID

DWD Pharma

DISP-TAB

50mg

10

35.00

HYCIN

Saga Labs

TAB

150mg

10

126.00

DT-TAB

50mg

10

49.50

ODIROX

Protec

TAB

150mg

10

97.50

TAB

300mg

5

95.00

ROKCIN

Plethico

F-C TAB

150mg

10

95.88

F-C TAB

50mg

10

38.86

ROXACE

Ind-Chemie

TAB

150mg

10

85.00

DISP-TAB

50mg

10

40.00

ROXEM

Arsto

TAB

150mg

10

95.61

KID-TAB

50mg

10

42.27

SUSP

50mg/ml

10

35.23

ROXEPTIN

IPCA

TAB

150mg

10

90.00

ROXETOMIN

Sun Pharma

KID-TAB

50mg

10×10

330.00

TAB

150mg

10×10

690.00

ROXIBEST

Blue cross

TAB

150mg

10

70.00

ROXIBEST-P

Blue Cross

TAB

50mg

10

33.00

ROXIBID

Zeita

TAB

150mg

4

58.00

ROXID

Alembic

TAB

150mg

10

110.20

TAB

300mg

4

86.05

KID-TAB

50mg

10

48.05

LIQUID

50mg/ml

30ml

38.25

ROXILIN

Lincoin

TAB

150mg

10

99.00

TAB

50mg

10

45.50

ROXIMOL

Torrent

TAB

150mg

10

109.00

TAB

50mg

10

40.00

REOXISARA

Sarabhai

TAB

150mg

10

90.02

TAB

300mg

10

165.64

DISP TAB

50mg

10

33.12

SUSP

50mg/5ml

10

38.12

ROXITEM

Kramer

TAB

150mg

6

56.00

KID-TAB

50mg

10

38.90

ROXITHRO

Rexcel

TAB

150mg

10

108.00

TAB

300mg

5

73.75

KID-TAB

50mg

10

47.00

ROXITIS

Medley

TAB

50mg

10

44.70

TAB

150mg

10

94.80

ROXYROL

Concept

TAB

150mg

4

36.75

KID-DIS

50mg

10

38.28

RULIDE

Roussel

K-TAB

50mg

10

46.75

TAB

150mg

10

112.50

TAB

300mg

5

107.38

THROX

Alkem

TAB

150mg

10

83.00

TAB

50mg

10

37.00

TROXY

Aglowmed

TAB

150mg

10

79.00

TRUROX

150mg

10

Menarini

TAB

100.00

UNOROX

150mg

10

Centaur

TABS

68.95

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By |2022-07-20T16:42:48+00:00July 20, 2022|Uncategorized|Comments Off on Roxithromycin

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