Drug Information

 





     










Pharmacokinetics.

 


Selegiline is readily absorbed from the gastrointestinal tract from
conventional preparations and crosses the blood-brain barrier. It
undergoes extensive first-pass metabolism in the liver to produce at
least 5 metabolites, including l-(-)-desmethylselegiline (norselegiline),
l-(-)-N-methylamphetamine and l-(-)-amphetamine. Concentrations of
selegiline metabolites are greatly reduced following administration of
the oral lyophilisate preparation, the majority of which undergoes
absorption through the buccal mucosa. It is excreted as metabolites
mainly in the urine and approximately 15% appears in the faeces.


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Indication
& Dosage




Oral

ADJUCT IN PARKINSON PATIENTS ON LEVADOPA/CARBIDOPA

THERAPY: 10mg/day administered as divided doses of 5mg each taken at
breakfast and lunch. There is no evidence that higher doses offer
additional benefits.


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Action



Selegiline’s beneficial adjunctive action in the treatment of
parkinson’ disease is, in part, due to inhibition of MAO-B. In addition
there is eveidence that this may act through other mechanisms to
increase dopaminergic activity.


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Interaction

Meperidine:
Contraindicated for use with meperidine since reports of fatal
interactions related to its MAO inhibiting activity.

Analgesic: Hyperpyrexia and CNS toxicity with pethidine. 

Antidepressants: Hypertension and CNS excitation with fluoxetine.






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Adverse Effect &
Precautions









Nausea, confusion, involuntary
movement, skin rash and psycholosis.



Precaution: Children cardiac arrhythmias, psychosis.

Pregnancy: Safety not established.

Breast Feeding: Use with caution

Man: May be given in reduced dose.


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Brands
available in market

 





















ELDEPRYL

Themis Chemicals
TAB 5mg 10 38.21
TAB 10mg 10 66.32
ELEGELIN

Sun Pharma
TAB 5mg 10 35.00
JUMEX

Torrent
TAB 5mg 10 36.90
SELERIN

Protec
TAB 5mg 10 32.50
SELGIN

Intas
TAB 5mg 10 35.50










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Drug Information
 

     

Pharmacokinetics.
 
Selegiline is readily absorbed from the gastrointestinal tract from conventional preparations and crosses the blood-brain barrier. It undergoes extensive first-pass metabolism in the liver to produce at least 5 metabolites, including l-(-)-desmethylselegiline (norselegiline), l-(-)-N-methylamphetamine and l-(-)-amphetamine. Concentrations of selegiline metabolites are greatly reduced following administration of the oral lyophilisate preparation, the majority of which undergoes absorption through the buccal mucosa. It is excreted as metabolites mainly in the urine and approximately 15% appears in the faeces.

 TOP
  

Indication & Dosage

Oral
ADJUCT IN PARKINSON PATIENTS ON LEVADOPA/CARBIDOPA
THERAPY: 10mg/day administered as divided doses of 5mg each taken at breakfast and lunch. There is no evidence that higher doses offer additional benefits.

 TOP
  

Action

Selegiline’s beneficial adjunctive action in the treatment of parkinson’ disease is, in part, due to inhibition of MAO-B. In addition there is eveidence that this may act through other mechanisms to increase dopaminergic activity.

 TOP
  

Interaction

Meperidine: Contraindicated for use with meperidine since reports of fatal interactions related to its MAO inhibiting activity.
Analgesic: Hyperpyrexia and CNS toxicity with pethidine. 
Antidepressants: Hypertension and CNS excitation with fluoxetine.


 TOP

 

Adverse Effect & Precautions

Nausea, confusion, involuntary movement, skin rash and psycholosis.

Precaution: Children cardiac arrhythmias, psychosis.
Pregnancy: Safety not established.
Breast Feeding: Use with caution
Man: May be given in reduced dose.

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ELDEPRYL

Themis Chemicals

TAB

5mg

10

38.21

TAB

10mg

10

66.32

ELEGELIN

Sun Pharma

TAB

5mg

10

35.00

JUMEX

Torrent

TAB

5mg

10

36.90

SELERIN

Protec

TAB

5mg

10

32.50

SELGIN

Intas

TAB

5mg

10

35.50


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By |2022-07-20T16:44:57+00:00July 20, 2022|Uncategorized|Comments Off on Selegiline

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