Drug Information

   


      











 

Pharmacokinetics
.



After oral adminstation, it is slowly aborbed form GI tract with peak
plasma levels (of 20-55 ug/l) at around 6-8 hours. Steady state plasma
concentration are reached approx. after 1 week of daily administration.
Plasma protein binding is 99% . Brain concentrations of the drug exceed
40 times those of plasma undergoes extensive hepatic first pass
metabolism.


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Indication
& Dosage





Oral

DEPRESSION:
Initially 50mg o.i, if the patient is not reponding,
increase in 50mg increments at intervals of not less than 1 wek, up to a
max. 200mg/day. Usual effective dosage; 50-200mg/day. Maint.;
50-200mg/day.


OBSESSIVE-COMPULSIVE DISORDER(OCD):
Usual effective dosage;
50-200mg/day.

PANIC DISORDER: Initially start with 25mg o.d.; after a week, increase
to 50mg 0.d. Usual effective dosage; 50-200mg/day


MAIN TREATMENT OF OCD AND PANIC DISORDER:
Properly reassess the need and
dose requred individually, if the treatment beyond 12-weeks is required.
Administer either in the morning or evening. Children: Not recommended.
Elderly: Dose adjustments are not required. Hepatic/Renal impairment:
Either lower dose or less frequent dosage is preferred.

 


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Action




Potent and selective  inhibitory action of sertraline on CNS
neuronal uptake of 5-HT results in increased concentrations of the
latter ath the synptic clefts, leading to facilitation of its sustained
activity at the postsynaptic receptor sites. WHich ultmately results in
an improvement of depression. Reduction of serotonin turnover(in brain)
by sertraline is also another contributing fact implicated in its
action. Its prolonged elimination half -life(about 26 hrs) offers a
benefit of once-daily administration.

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Interaction



Desipramine, diazepam, digoxin and alcohol: No significant interaction
reported.

Lithium: On concomitant use, increased incidence of mild to moderate
tremors has been observed.

Warfarin: Sertraline with warfarin may increase prothrombin time.






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Adverse
Effect & Precautions




They are usually dose related, mild and transient in nature and decrease
in frequency with continued treatment. Nausea, headache, dry mouth,
diarrhoea, insomnia, disziness, tremor, fatigue, somnolescence.



Precaution: Stop MAOI therapy at least 2 weeks pror to starting
sertraline therapy. Sertraline should be avoided in unstable epilepsy.
In controlled epilepsy, careful monitoring is epilepsy. While on
sertraline therapy, activites requiring alertness or skill should be
avoided. There is insufficient experience of sertraline’s use in acute
coronary syndromes. Patients with renal hepatic impairment should be
moniotred.

Pregnancy: Use only if therapy clearly indicated. Lack of adequate data
requiring safety.

Breast Feeding: Do not use.

Man: No special risk. Occasionally SIADH develops with therapy.





 
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Brands
available in market


 


















SERENATA

Torrent
TABS 50mg 10 24.00
TABS 100mg 10 47.00
SERTA

Unisearch
TABS 100mg 10 45.00
TABS 50mg 10 25.00
SERTIL

SPPL
TABS 50mg 10 25.00
TABS 100mg 10 48.00
ZOSERT

Sun Pharma
TABS 50mg 10 26.50




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Drug Information
   

      

 
Pharmacokinetics
.

After oral adminstation, it is slowly aborbed form GI tract with peak plasma levels (of 20-55 ug/l) at around 6-8 hours. Steady state plasma concentration are reached approx. after 1 week of daily administration. Plasma protein binding is 99% . Brain concentrations of the drug exceed 40 times those of plasma undergoes extensive hepatic first pass metabolism.

 TOP
    

Indication & Dosage

Oral
DEPRESSION:
Initially 50mg o.i, if the patient is not reponding, increase in 50mg increments at intervals of not less than 1 wek, up to a max. 200mg/day. Usual effective dosage; 50-200mg/day. Maint.; 50-200mg/day.
OBSESSIVE-COMPULSIVE DISORDER(OCD): Usual effective dosage; 50-200mg/day.
PANIC DISORDER: Initially start with 25mg o.d.; after a week, increase to 50mg 0.d. Usual effective dosage; 50-200mg/day
MAIN TREATMENT OF OCD AND PANIC DISORDER: Properly reassess the need and dose requred individually, if the treatment beyond 12-weeks is required. Administer either in the morning or evening. Children: Not recommended. Elderly: Dose adjustments are not required. Hepatic/Renal impairment: Either lower dose or less frequent dosage is preferred.

 

TOP
  

Action

Potent and selective  inhibitory action of sertraline on CNS neuronal uptake of 5-HT results in increased concentrations of the latter ath the synptic clefts, leading to facilitation of its sustained activity at the postsynaptic receptor sites. WHich ultmately results in an improvement of depression. Reduction of serotonin turnover(in brain) by sertraline is also another contributing fact implicated in its action. Its prolonged elimination half -life(about 26 hrs) offers a benefit of once-daily administration.

TOP
    

Interaction

Desipramine, diazepam, digoxin and alcohol: No significant interaction reported.
Lithium: On concomitant use, increased incidence of mild to moderate tremors has been observed.
Warfarin: Sertraline with warfarin may increase prothrombin time.


 TOP
  

Adverse Effect & Precautions

They are usually dose related, mild and transient in nature and decrease in frequency with continued treatment. Nausea, headache, dry mouth, diarrhoea, insomnia, disziness, tremor, fatigue, somnolescence.

Precaution: Stop MAOI therapy at least 2 weeks pror to starting sertraline therapy. Sertraline should be avoided in unstable epilepsy. In controlled epilepsy, careful monitoring is epilepsy. While on sertraline therapy, activites requiring alertness or skill should be avoided. There is insufficient experience of sertraline’s use in acute coronary syndromes. Patients with renal hepatic impairment should be moniotred.
Pregnancy: Use only if therapy clearly indicated. Lack of adequate data requiring safety.
Breast Feeding: Do not use.
Man: No special risk. Occasionally SIADH develops with therapy.


 
TOP
  

SERENATA

Torrent

TABS

50mg

10

24.00

TABS

100mg

10

47.00

SERTA

Unisearch

TABS

100mg

10

45.00

TABS

50mg

10

25.00

SERTIL

SPPL

TABS

50mg

10

25.00

TABS

100mg

10

48.00

ZOSERT

Sun Pharma

TABS

50mg

10

26.50

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By |2022-07-20T16:42:53+00:00July 20, 2022|Uncategorized|Comments Off on Sertraline

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