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Drug Information
Pharmacokinetics
| Indication
& Dosage | Action
| Interactions Adverse
Effects & Precautions |
Brands available in Market
Pharmacokinetics
Silver sulphadiazine slowly releases sulphadiazine when in contact with
wound exudates. Up to about 10% of the sulphadiazine may be absorbed;
concentrations in blood of 10 to 20 micrograms per mL have been reported
although higher concentrations may be achieved when extensive areas of
the body are treated. Some silver may also be absorbed.
Indication
& Dosage
Topical Skin
ADJUNCT IN THE PRVENTION AND TREATMENT OF WOUND SEPSIS INPATIENTS WITH
2ND AND 3RD DEGREE BURNS: Silver Sulfadiazine cream 1 % is applied under
sterile conditions after debridement of burn wounds. Burn areas should
be covered with cream at all times. The cream should be applied once to
twice daily to a thickness of approximately 1/16 inch.
Action
It has broad antimicobial activity; bactericidal for many
gram-negative and gram-positive bacteria as well as being effective
against yeast. It act on cell membrane and cell wall to produce its
bactericidal effect.
Interaction
Silver sulphadiazine is not antagonised by p-aminobenzoic acid or
related compounds. The silver content of silver sulphadiazine may
inactivate enzymatic debriding agents.
Adverse
Effect & Precautions
Are rarely seen with ophthalmic use.
Acute leucopenia has been observed in patients treated with silver
sulphadiazine topically. Skin rash has been reported.
Pregnancy: Contraindicated.
Breast Feeding: May be used.
Man: May be used.
