Drug Information

 


                                 











 

Pharmacokinetics





Silver sulphadiazine slowly releases sulphadiazine when in contact with
wound exudates. Up to about 10% of the sulphadiazine may be absorbed;
concentrations in blood of 10 to 20 micrograms per mL have been reported
although higher concentrations may be achieved when extensive areas of
the body are treated. Some silver may also be absorbed.


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Indication
& Dosage


 


Topical Skin

ADJUNCT IN THE PRVENTION AND TREATMENT OF WOUND SEPSIS INPATIENTS WITH
2ND AND 3RD DEGREE BURNS: Silver Sulfadiazine cream 1 % is applied under
sterile conditions after debridement of burn wounds. Burn areas should
be covered with cream at all times. The cream should be applied once to
twice daily to a thickness of approximately 1/16 inch.

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Action



It has broad antimicobial activity; bactericidal for many
gram-negative and gram-positive bacteria as well as being effective
against yeast. It act on cell membrane and cell wall to produce its
bactericidal effect.


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Interaction

 


Silver sulphadiazine is not antagonised by p-aminobenzoic acid or
related compounds. The silver content of silver sulphadiazine may
inactivate enzymatic debriding agents.

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Adverse
Effect & Precautions






Are rarely seen with ophthalmic use.
Acute leucopenia has been observed in patients treated with  silver
sulphadiazine topically. Skin rash has been reported.

Pregnancy: Contraindicated.

Breast Feeding: May be used.

Man: May be used.

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Brands
available in market




















SILVER SULFA

Indon
CREAM 1% w/w 25g 15.90
CREAM 1% w/w 250g 89.50
SILVER SUPHADIAZINE

Duphar-Interfran
CREAM 1% w/w 25g 22.80
CREAM 1% w/w 500g 199.00
SILVINDON

Indon
CREAM 1% 25g 11.53
CREAM 1% 250g 73.14
SILVIRIN

Raptakos
CREAM 1% w/w 20g 9.50
CREAM 1% w/w 250g 82.25









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Drug Information
 

                                 

 
Pharmacokinetics


Silver sulphadiazine slowly releases sulphadiazine when in contact with wound exudates. Up to about 10% of the sulphadiazine may be absorbed; concentrations in blood of 10 to 20 micrograms per mL have been reported although higher concentrations may be achieved when extensive areas of the body are treated. Some silver may also be absorbed.

TOP
    

Indication & Dosage
 
Topical Skin
ADJUNCT IN THE PRVENTION AND TREATMENT OF WOUND SEPSIS INPATIENTS WITH 2ND AND 3RD DEGREE BURNS: Silver Sulfadiazine cream 1 % is applied under sterile conditions after debridement of burn wounds. Burn areas should be covered with cream at all times. The cream should be applied once to twice daily to a thickness of approximately 1/16 inch.

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Action

It has broad antimicobial activity; bactericidal for many gram-negative and gram-positive bacteria as well as being effective against yeast. It act on cell membrane and cell wall to produce its bactericidal effect.

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Interaction
 

Silver sulphadiazine is not antagonised by p-aminobenzoic acid or related compounds. The silver content of silver sulphadiazine may inactivate enzymatic debriding agents.

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Adverse Effect & Precautions

Are rarely seen with ophthalmic use. Acute leucopenia has been observed in patients treated with  silver sulphadiazine topically. Skin rash has been reported.
Pregnancy: Contraindicated.
Breast Feeding: May be used.
Man: May be used.

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SILVER SULFA

Indon

CREAM

1% w/w

25g

15.90

CREAM

1% w/w

250g

89.50

SILVER SUPHADIAZINE

Duphar-Interfran

CREAM

1% w/w

25g

22.80

CREAM

1% w/w

500g

199.00

SILVINDON

Indon

CREAM

1%

25g

11.53

CREAM

1%

250g

73.14

SILVIRIN

Raptakos

CREAM

1% w/w

20g

9.50

CREAM

1% w/w

250g

82.25


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By |2022-07-20T16:42:52+00:00July 20, 2022|Uncategorized|Comments Off on Silver Sulphadiazine

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