Drug Information

 













 


Pharmacokinetics.



                

 

Indication
& Dosage





Parenteral

SEPTICEMIA AND OTHER INFECTIONS DUE TO GRAM NEGATIVE AEROBIC BACILLI
ABOMINAL SURGICAL INFECTIONS. BILIARY TRACT INFECTIONS. BACTERIAL
ENDOCARDITIS, USUALLY IN COMBINATION WITH A INCECTIONS: Adult 3mg/kg/day
IM in three divided doses. Sisomicin  may be given by IV, infusion,
if necessary Children: Over 1 year ago 3-4.5mg/kg/day. Neonates(upto 10
days old): 2.5mg/kg every. 12 hours Usual durationof treatment: 7-10
days.






TOP 

        

Action



It is bactericidal antibiotic which acts by inhibiting normal
protein synthesis in susceptible microorganisms. It is acitveagainst a
wide variety of pathogenic bacteria including E.coli, proteus spp;
pseudomonas aeruginosa, spp. ofKlebssella-Enterobacter-Serratia group.
Citrobacter spp., Staphylococcus spp. (including penicillin and
methicillin resistant strains). Active in vitro against spp. of
salmonella and shigella. Though pharmacologically similar to gentamicin,
it appears to be somewhat move active agianst pseudomonas aeruginosa.

TOP


  

Interaction



Aminoglycosides, AMphotericin B, Bacitracin, Cisplatin,
Cephalothin, Vancomycin, Methoxyflurane Ethacrynic Acid, Furosemide,
Bumetanide & Mannitol: Increased ototoxic, neurotoxic or nephrotoxic
affects. Anaesthetics, Neuromascular blocking agents (Tubocurarine,
Gallamine): Risk of neuromuscular blockade and respiratory paralysis.

Penicilline, Cephalosporins antibiotic synergism, especially useful in
Psuedomonas infections.

Lab Test: Aminoglycoside serum levels: Guard against in vitro
inactivation of aminoglycosides by Beta-lactum antibiotics in patients
on combination therapy.

TOP

  

Adverse
Effect & Precautions






Nausea, vomiting and
diarrhoea on oral administration. I.M. injection causes pain,
paraesthesias & flushing. Ototoxicity, neurotoxicity and
nephrotoxicity.



Precautions: Renal dysfunction, perforated tympanic membrance. When
given i.m or intrathecally, administer only to hospitalised patients.

Pregnancy: Safety not established.

Breast Feeding: Safety not established.

Man: Use with caution.

TOP

   

Brands
available in market


 













ENSAMYCIN

Fulford
IM/IV INJ 50mg/ml 1ml amp 41.68
IM/IV INJ 10mg/ml 1ml amp 13.34
SISOPTIN

Themis Pharma
INJ 10mg 1ml 9.13
INJ 50mg 1ml 32.84



 TOP

  


                   






 

 

 

 
Drug Information
 


 
Pharmacokinetics.
                
 

Indication & Dosage

Parenteral
SEPTICEMIA AND OTHER INFECTIONS DUE TO GRAM NEGATIVE AEROBIC BACILLI ABOMINAL SURGICAL INFECTIONS. BILIARY TRACT INFECTIONS. BACTERIAL ENDOCARDITIS, USUALLY IN COMBINATION WITH A INCECTIONS: Adult 3mg/kg/day IM in three divided doses. Sisomicin  may be given by IV, infusion, if necessary Children: Over 1 year ago 3-4.5mg/kg/day. Neonates(upto 10 days old): 2.5mg/kg every. 12 hours Usual durationof treatment: 7-10 days.


TOP 
        

Action

It is bactericidal antibiotic which acts by inhibiting normal protein synthesis in susceptible microorganisms. It is acitveagainst a wide variety of pathogenic bacteria including E.coli, proteus spp; pseudomonas aeruginosa, spp. ofKlebssella-Enterobacter-Serratia group. Citrobacter spp., Staphylococcus spp. (including penicillin and methicillin resistant strains). Active in vitro against spp. of salmonella and shigella. Though pharmacologically similar to gentamicin, it appears to be somewhat move active agianst pseudomonas aeruginosa.

TOP
  

Interaction

Aminoglycosides, AMphotericin B, Bacitracin, Cisplatin, Cephalothin, Vancomycin, Methoxyflurane Ethacrynic Acid, Furosemide, Bumetanide & Mannitol: Increased ototoxic, neurotoxic or nephrotoxic affects. Anaesthetics, Neuromascular blocking agents (Tubocurarine, Gallamine): Risk of neuromuscular blockade and respiratory paralysis.
Penicilline, Cephalosporins antibiotic synergism, especially useful in Psuedomonas infections.
Lab Test: Aminoglycoside serum levels: Guard against in vitro inactivation of aminoglycosides by Beta-lactum antibiotics in patients on combination therapy.

TOP
  

Adverse Effect & Precautions

Nausea, vomiting and diarrhoea on oral administration. I.M. injection causes pain, paraesthesias & flushing. Ototoxicity, neurotoxicity and nephrotoxicity.

Precautions: Renal dysfunction, perforated tympanic membrance. When given i.m or intrathecally, administer only to hospitalised patients.
Pregnancy: Safety not established.
Breast Feeding: Safety not established.
Man: Use with caution.

TOP
   

ENSAMYCIN

Fulford

IM/IV INJ

50mg/ml

1ml amp

41.68

IM/IV INJ

10mg/ml

1ml amp

13.34

SISOPTIN

Themis Pharma

INJ

10mg

1ml

9.13

INJ

50mg

1ml

32.84

 TOP
  

                   

 

By |2022-07-20T16:44:57+00:00July 20, 2022|Uncategorized|Comments Off on Sisomicin

About the Author: