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Drug Information
Pharmacokinetics
| Indication
& Dosage | Action
| Interactions |Adverse
Effects & Precautions |
Brands available in Market
Pharmacokinetics
Sodium fusidate is well absorbed from the gastrointestinal tract, and a
single 500-mg dose is reported to produce mean plasma concentrations of
about 30 micrograms per mL 2 to 4 hours after administration, although
there is considerable interindividual variation. Oral suspensions of
fusidic acid are less well absorbed, and a 500-mg dose of such a
suspension is reported to produce peak plasma concentrations of about 23
micrograms per mL. Absorption may be delayed by food, but may be more
rapid in children than adults. Some accumulation occurs with repeated
administration and plasma concentrations of 100 micrograms per mL or
more have been reported following 500 mg of sodium fusidate three times
daily for 4 days.
Fusidate is widely distributed into tissues and body fluids, including
bone, pus, and synovial fluid; it penetrates cerebral abscesses but does
not enter CSF in appreciable amounts. It has been found in the fetal
circulation and in breast milk. About 95% or more of fusidate in the
circulation is bound to plasma protein.
Fusidate has a plasma half-life that has been variously reported as 5 to
6 and 10 to 15 hours. It is excreted in the bile, almost entirely as
metabolites some of which have weak antimicrobial activity. About 2%
appears unchanged in the faeces. Little is excreted in the urine or
removed by haemodialysis.
Indication
& Dosage
Topical Skin
LOCAL TREATMENT OF SKIN INFECTIONS CAUSED BY SUSCEPTIBLE ORGANISMS: 2%
cream or ointment to be applied 2-3 times a day.
Action
It is mainly active against gram-postive bacteria-staphylococci,
clostridral strains and Nacardia asteroides. This act by inhibiting
bacterial protein synthesis. It is given by ,outh or intravenously, and
is also applied topically in various forms.
Adverse
Effect & Precautions
Rashes, irritation, resistance.
Precaution: Not to be applied in the eyes.
Pregnancy: Use with caution.
Breast Feeding: Contraindicated.
Man: Use with caution.
