Drug Information

 


  














 
 

Pharmacokinetics


 



Sodium fusidate is well absorbed from the gastrointestinal tract, and a
single 500-mg dose is reported to produce mean plasma concentrations of
about 30 micrograms per mL 2 to 4 hours after administration, although
there is considerable interindividual variation. Oral suspensions of
fusidic acid are less well absorbed, and a 500-mg dose of such a
suspension is reported to produce peak plasma concentrations of about 23
micrograms per mL. Absorption may be delayed by food, but may be more
rapid in children than adults. Some accumulation occurs with repeated
administration and plasma concentrations of 100 micrograms per mL or
more have been reported following 500 mg of sodium fusidate three times
daily for 4 days.

Fusidate is widely distributed into tissues and body fluids, including
bone, pus, and synovial fluid; it penetrates cerebral abscesses but does
not enter CSF in appreciable amounts. It has been found in the fetal
circulation and in breast milk. About 95% or more of fusidate in the
circulation is bound to plasma protein.

Fusidate has a plasma half-life that has been variously reported as 5 to
6 and 10 to 15 hours. It is excreted in the bile, almost entirely as
metabolites some of which have weak antimicrobial activity. About 2%
appears unchanged in the faeces. Little is excreted in the urine or
removed by haemodialysis.

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Indication
& Dosage




Topical Skin

LOCAL TREATMENT OF SKIN INFECTIONS CAUSED BY SUSCEPTIBLE ORGANISMS: 2%
cream or ointment to be applied 2-3 times a day.

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Action




It is mainly active against gram-postive bacteria-staphylococci,
clostridral strains and Nacardia asteroides. This act by inhibiting
bacterial protein synthesis. It is given by ,outh or intravenously, and
is also applied topically in various forms.

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Interaction



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Adverse
Effect & Precautions




Rashes, irritation, resistance.



Precaution: Not to be applied in the eyes.

Pregnancy: Use with caution.

Breast Feeding: Contraindicated.

Man: Use with caution.

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Brands
available in market


 



















FUCIDIN

Croslands
CREAM 20mg 10g 59.50
OINT 2% 10g 59.50
FUSIDERM

Indipharma
OINT 2% 5g 28.00
FUSIGEN

Geno
OINT 20mg/g 5g 26.92
FUSIWAL

Wallace
OINT 2% 5g 29.00









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Drug Information
 

  

   
Pharmacokinetics

 

Sodium fusidate is well absorbed from the gastrointestinal tract, and a single 500-mg dose is reported to produce mean plasma concentrations of about 30 micrograms per mL 2 to 4 hours after administration, although there is considerable interindividual variation. Oral suspensions of fusidic acid are less well absorbed, and a 500-mg dose of such a suspension is reported to produce peak plasma concentrations of about 23 micrograms per mL. Absorption may be delayed by food, but may be more rapid in children than adults. Some accumulation occurs with repeated administration and plasma concentrations of 100 micrograms per mL or more have been reported following 500 mg of sodium fusidate three times daily for 4 days.
Fusidate is widely distributed into tissues and body fluids, including bone, pus, and synovial fluid; it penetrates cerebral abscesses but does not enter CSF in appreciable amounts. It has been found in the fetal circulation and in breast milk. About 95% or more of fusidate in the circulation is bound to plasma protein.
Fusidate has a plasma half-life that has been variously reported as 5 to 6 and 10 to 15 hours. It is excreted in the bile, almost entirely as metabolites some of which have weak antimicrobial activity. About 2% appears unchanged in the faeces. Little is excreted in the urine or removed by haemodialysis.

TOP

  

 
Indication & Dosage


Topical Skin
LOCAL TREATMENT OF SKIN INFECTIONS CAUSED BY SUSCEPTIBLE ORGANISMS: 2% cream or ointment to be applied 2-3 times a day.

TOP

 

 
Action


It is mainly active against gram-postive bacteria-staphylococci, clostridral strains and Nacardia asteroides. This act by inhibiting bacterial protein synthesis. It is given by ,outh or intravenously, and is also applied topically in various forms.

TOP

 

 
Adverse Effect & Precautions


Rashes, irritation, resistance.

Precaution: Not to be applied in the eyes.
Pregnancy: Use with caution.
Breast Feeding: Contraindicated.
Man: Use with caution.

TOP  

 

FUCIDIN

Croslands

CREAM

20mg

10g

59.50

OINT

2%

10g

59.50

FUSIDERM

Indipharma

OINT

2%

5g

28.00

FUSIGEN

Geno

OINT

20mg/g

5g

26.92

FUSIWAL

Wallace

OINT

2%

5g

29.00



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By |2022-07-20T16:42:45+00:00July 20, 2022|Uncategorized|Comments Off on SOD. FUSIDATE

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