Drug Information

  


                                       














 

Pharmacokinetics.

 


Sodium nitroprusside is
converted in the erythrocytes to cyanide. Nitric oxide is also released
in vivo. Cyanide is metabolised in the liver to thiocyanate by the
enzyme rhodanase in the presence of thiosulphate and slowly excreted in
the urine. The plasma half-life of thiocyanate is reported to be about 3
days, but may be much longer in patients with renal impairment.

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Indication
& Dosage


 


IV Infusion

HYPERTENSIVE CRISIS:
Initially 0.3mcg/kg/min, then adjusted; usual range
0.5-0.6 mcg/kg/min (20-400mcg/min); Max. 8mcg/kg/min (if response, give
for only few hours to avoid cyanide risk); lower doses for patients
already being treated with other antihypertensives and in the felderly.


CONTROLLED HYPOTENSION DURING ANESTHESIA 7 SURGERY:
Infusion at lower
doses(max. 1.5mcg/kg/min)

HEART FAILURE: Initially 10-15 mcg/min increased every 5-10 min as
necessary; usual range 10-200mcg/min. Max 280 mcg/min(4mcg/kg/min).







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Action

 


It acts by relaxation of vascular smooth muscle; consequently
it dilates peripheral arteries and veins. It is more active on veins
than on arteries. It reduces both preload & afterload which will
reduce workload on the heart. In hypertensive patients, moderate doses
induce renal vasodilation roughly proportional to the decrease
insystemic appreciable change in RBF and GFR. Hypotensive effect is seen
within a minute or two after the start of an adequate infusion, and it
dissipates almost as rapidly after infusion is discontinued.

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Interaction

 


D
iuretics, Inotropic agents:
Useful combination in cardiac failure.

Antihypertensives: Sensitivity enhanced by antihypertensives.

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Adverse
Effect & Precautions



 


Nausea, vomiting, nervousness,
palpitation, sweating, headache, disorientation, methaemoglobinaemia.



Precaution: Sodium nitroprusside decomposes on exposure to light, so the
container must be covered with black paper.

Pregnancy: Use only if clearly indicated.

Breat Feeding: Safety not established.

Man: May be used.

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Brands
available in market


 














PRUSIDE

Troikaa
INJ 50mg/ml 5ml 140.00
SONIDE

Gufic
INJ 50mg 5ml 44.81




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Drug Information
  

                                       

 
Pharmacokinetics.
 
Sodium nitroprusside is converted in the erythrocytes to cyanide. Nitric oxide is also released in vivo. Cyanide is metabolised in the liver to thiocyanate by the enzyme rhodanase in the presence of thiosulphate and slowly excreted in the urine. The plasma half-life of thiocyanate is reported to be about 3 days, but may be much longer in patients with renal impairment.

TOP

 

Indication & Dosage
 
IV Infusion
HYPERTENSIVE CRISIS:
Initially 0.3mcg/kg/min, then adjusted; usual range 0.5-0.6 mcg/kg/min (20-400mcg/min); Max. 8mcg/kg/min (if response, give for only few hours to avoid cyanide risk); lower doses for patients already being treated with other antihypertensives and in the felderly.
CONTROLLED HYPOTENSION DURING ANESTHESIA 7 SURGERY: Infusion at lower doses(max. 1.5mcg/kg/min)
HEART FAILURE: Initially 10-15 mcg/min increased every 5-10 min as necessary; usual range 10-200mcg/min. Max 280 mcg/min(4mcg/kg/min).



TOP

 

Action
 
It acts by relaxation of vascular smooth muscle; consequently it dilates peripheral arteries and veins. It is more active on veins than on arteries. It reduces both preload & afterload which will reduce workload on the heart. In hypertensive patients, moderate doses induce renal vasodilation roughly proportional to the decrease insystemic appreciable change in RBF and GFR. Hypotensive effect is seen within a minute or two after the start of an adequate infusion, and it dissipates almost as rapidly after infusion is discontinued.

TOP

 

Interaction
 

D
iuretics, Inotropic agents: Useful combination in cardiac failure.
Antihypertensives: Sensitivity enhanced by antihypertensives.

TOP

 

Adverse Effect & Precautions
 
Nausea, vomiting, nervousness, palpitation, sweating, headache, disorientation, methaemoglobinaemia.

Precaution: Sodium nitroprusside decomposes on exposure to light, so the container must be covered with black paper.
Pregnancy: Use only if clearly indicated.
Breat Feeding: Safety not established.
Man: May be used.

TOP

 

PRUSIDE

Troikaa

INJ

50mg/ml

5ml

140.00

SONIDE

Gufic

INJ

50mg

5ml

44.81

TOP

 

                                                     
                                               

 

By |2022-07-20T16:41:21+00:00July 20, 2022|Uncategorized|Comments Off on Sodium Nitroprusside

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