Drug Information

 


    











 

Pharmacokinetics


 



After administration Valproic acid is highly protein bound, it is
extensively metabolised in liver.


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Indication
& Dosage




Oral

PRIMARY GENERALISED SEIZURES INCLUDING PETIT-MAL, TONIC-CLONIC AND
MYOCLONIC SEZURES, PARTIAL SEIZURES
: Adults: Inital daily of 600mg in
divided doses; increase by 200mg at 3 day intervals until control of
seizures is achieved. Usual maintenance dose rages between 1000 and
2000mg/day or 20-30mg/kg B.W. Children: (Over 20kg)-400mg/day. (under
20kg)-20mg/kg/day.


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Action

 


It is an antiepileptic which dissociates to the valproate
ionin the GIT. Though the mechanism of action is not fully known, it has
been suggested that its antiepileptic activity is related to increased
brain levels of GABA.


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Interaction

 

Charcoal: Absorption of sodium valproate is decrease.

Chlorpromazine Cimetidine: Decreased clearance and increased half-life
of sodium valproate.

Salicylates: Serum levels of sodium valproate elevated leading to
toxicity.

Alcohol & other CNS depressants: CNS depressant effect potentiated.

Phenobarbital, Primidone: May result in increased phenobarbital level
and an increase in CNS effects.

Carbamazepine, Clonazepam, Ethosuximede, Phenytoin: Variable changes in
the effects of these agents and on sodium valproate.

Lab Tests: False interpretation of urine ketone test. Altered thyroid
function tests may occur.


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Adverse
Effect & Precautions


 

Anorexia, nausea, vomiting, abdominal pain and diarrhoea. Sedation,
ataxia, vertigo, drowsiness, alopecia (reversible), weight gain and
fulmunant hepatitis. Hepatotoxicity occurs mostly in children on
polypharmacy. Tremor, nystagmus, confusion, pancreatitis.



Precaution: In women of child bearing age (because of teratogenic
effect) and in patients of hepatic disease it may cause prolongationof
bleeding time. Frequent LFT should be done at beginning and first six
months of drug therapy. Valproic acid gives false positive in urine
testing for glucose. Abrupt withdrawl, impaired renal function. Use with
caution in patients receiving other anticonvulsants, Surgery.

Pregnancy: Contraindicated.

Breast Feeding: Use with caution.

Man: May be given in reduced dose.


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Brands
available in market
































ENCORATE

Sun Pharma

SYRUP

200mg/5ml

100ml

45.90

TAB

500mg

10

35.00

TAB

200mg

10

18.90

ENCORATE 300

Sun

TAB

300mg

5×10

117.50

EPILEX

Reckitt & Colman

TAB

200mg

10

19.50

SYRUP

200mg/5ml

100ml

47.50

EPIVAL

Sun Pharma

TAB

200mg

10

18.90

SYRUP

200mg/5ml

60ml

69.50

SYRUP

200mg/5ml

200ml

59.00

EPSOVAL

LA Pharma

TABS

200mg

10

19.00

VALPARIN

Torrent

TAB

200mg

10

19.20

TAB

500mg

10

47.64

SYRUP

200mg

100ml

47.64

VALTRIL

Wockhardt-Merind

TAB

200mg

10

19.20

TAB

500mg

10

47.90


 




TOP


                                                                






 

                                                   

 
Drug Information
 

    

 
Pharmacokinetics

 

After administration Valproic acid is highly protein bound, it is extensively metabolised in liver.

TOP

 

Indication & Dosage

Oral
PRIMARY GENERALISED SEIZURES INCLUDING PETIT-MAL, TONIC-CLONIC AND MYOCLONIC SEZURES, PARTIAL SEIZURES
: Adults: Inital daily of 600mg in divided doses; increase by 200mg at 3 day intervals until control of seizures is achieved. Usual maintenance dose rages between 1000 and 2000mg/day or 20-30mg/kg B.W. Children: (Over 20kg)-400mg/day. (under 20kg)-20mg/kg/day.

TOP

 

Action
 
It is an antiepileptic which dissociates to the valproate ionin the GIT. Though the mechanism of action is not fully known, it has been suggested that its antiepileptic activity is related to increased brain levels of GABA.

TOP

 

Interaction
 
Charcoal: Absorption of sodium valproate is decrease.
Chlorpromazine Cimetidine: Decreased clearance and increased half-life of sodium valproate.
Salicylates: Serum levels of sodium valproate elevated leading to toxicity.
Alcohol & other CNS depressants: CNS depressant effect potentiated.
Phenobarbital, Primidone: May result in increased phenobarbital level and an increase in CNS effects.
Carbamazepine, Clonazepam, Ethosuximede, Phenytoin: Variable changes in the effects of these agents and on sodium valproate.
Lab Tests: False interpretation of urine ketone test. Altered thyroid function tests may occur.

TOP

 

Adverse Effect & Precautions
 
Anorexia, nausea, vomiting, abdominal pain and diarrhoea. Sedation, ataxia, vertigo, drowsiness, alopecia (reversible), weight gain and fulmunant hepatitis. Hepatotoxicity occurs mostly in children on polypharmacy. Tremor, nystagmus, confusion, pancreatitis.

Precaution: In women of child bearing age (because of teratogenic effect) and in patients of hepatic disease it may cause prolongationof bleeding time. Frequent LFT should be done at beginning and first six months of drug therapy. Valproic acid gives false positive in urine testing for glucose. Abrupt withdrawl, impaired renal function. Use with caution in patients receiving other anticonvulsants, Surgery.
Pregnancy: Contraindicated.
Breast Feeding: Use with caution.
Man: May be given in reduced dose.

TOP

 

ENCORATE

Sun Pharma

SYRUP

200mg/5ml

100ml

45.90

TAB

500mg

10

35.00

TAB

200mg

10

18.90

ENCORATE 300

Sun

TAB

300mg

5×10

117.50

EPILEX

Reckitt & Colman

TAB

200mg

10

19.50

SYRUP

200mg/5ml

100ml

47.50

EPIVAL

Sun Pharma

TAB

200mg

10

18.90

SYRUP

200mg/5ml

60ml

69.50

SYRUP

200mg/5ml

200ml

59.00

EPSOVAL

LA Pharma

TABS

200mg

10

19.00

VALPARIN

Torrent

TAB

200mg

10

19.20

TAB

500mg

10

47.64

SYRUP

200mg

100ml

47.64

VALTRIL

Wockhardt-Merind

TAB

200mg

10

19.20

TAB

500mg

10

47.90

 

TOP

                                                                

 

By |2022-07-20T16:44:55+00:00July 20, 2022|Uncategorized|Comments Off on Sodium Valproate

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