Drug Information

 


                   











 

Pharmacokinetics.

 



It is administered intranasal.

TOP


 

Indication
& Dosage


 


IV

ACUTE BLEEDING OESOPHAGEAL VARICES:
IV bolus of 250mcg over 1 min.,
followed by 6mg/24hr continous infusion x 4 days. Infusion should be
given. UPPER GI HEMORRHAGE FROM GASTRIC/DUODENAL ULCERS: IV bolus of
250mcg (3.5mcg/kg) followed by 3 mg 12 hourly continuous infusion x 2.5d
days; as necessary INTESTINAL & PANCREATIC FISTULAE: IV bolus not
reqd. Infusion(6mg/d) may be reqd. upt o 14 days. After closure of
fistulae infusion should be at half-dosage for the next 48 hrs.

TOP

  

Action

 


It is not only a hpothalamic hormone but also present in
g.i.t. & pancreas. It inhibits the release of GH, & its has also
been effective in bleeding oesophageal varices & GI haemorrhages.
Its beneficial effect in variceal hemorrhage is due to constriction of
splanchnic artery, which in turn reduces its blood flow & hepatic
blood flow, with subsequent lowering of variceal pressure.

TOP

 

Interaction

 

Analgesic: Effect of desmopressin potentiated by indomethacin.

TOP

 

Adverse
Effect & Precautions






Fluid retention, hyponatraemia on
administration, hyponatraemia on administration without restricting
fluid intake, stomach ache, headache, nausea. vomiting, epistaxis.
Alergic reactions ranging from urticaria to anaphylaxis may occur.



Precaution: Renal impairment, cardiovascular disease and
hypertension(not indicated for nocturnal enuresis and nocturia in those
over 65 years), cystic fibrosis.

Pregnancy: Contraindicated.

Breast Feeding: Contraindicated.

Man: Contraindicated.

TOP

 

Brands
available in market


 
















SOMATOSAN

Geman Remedies

INJ

2mg

1ml

3710.00

SOMATOSTATIN UCB

UCB Pharma

INJ

(Somatostatin (as acetate hydrate) 3mg
per vial suppplied with an ampoule containing Nacl 0.9% in 1ml
water for inj.)

3mg

vial

3675.00

INJ

Somatostatin (as acetate hydrate) 250mcg


3mg per vial suppplied with an ampoule containing Nacl 0.9% in1ml
water for inj.)

3mg

vial

590.00

STILAMIN

Serum Institute

AMP

250mcg

1

679.95

AMP

3mg

1

3993.42


TOP


                                                                                                    






 

         

 
Drug Information
 

                   

 
Pharmacokinetics.
 

It is administered intranasal.

TOP
 

Indication & Dosage
 
IV
ACUTE BLEEDING OESOPHAGEAL VARICES:
IV bolus of 250mcg over 1 min., followed by 6mg/24hr continous infusion x 4 days. Infusion should be given. UPPER GI HEMORRHAGE FROM GASTRIC/DUODENAL ULCERS: IV bolus of 250mcg (3.5mcg/kg) followed by 3 mg 12 hourly continuous infusion x 2.5d days; as necessary INTESTINAL & PANCREATIC FISTULAE: IV bolus not reqd. Infusion(6mg/d) may be reqd. upt o 14 days. After closure of fistulae infusion should be at half-dosage for the next 48 hrs.

TOP
  

Action
 
It is not only a hpothalamic hormone but also present in g.i.t. & pancreas. It inhibits the release of GH, & its has also been effective in bleeding oesophageal varices & GI haemorrhages. Its beneficial effect in variceal hemorrhage is due to constriction of splanchnic artery, which in turn reduces its blood flow & hepatic blood flow, with subsequent lowering of variceal pressure.

TOP

 

Interaction
 
Analgesic: Effect of desmopressin potentiated by indomethacin.

TOP

 

Adverse Effect & Precautions

Fluid retention, hyponatraemia on administration, hyponatraemia on administration without restricting fluid intake, stomach ache, headache, nausea. vomiting, epistaxis. Alergic reactions ranging from urticaria to anaphylaxis may occur.

Precaution: Renal impairment, cardiovascular disease and hypertension(not indicated for nocturnal enuresis and nocturia in those over 65 years), cystic fibrosis.
Pregnancy: Contraindicated.
Breast Feeding: Contraindicated.
Man: Contraindicated.

TOP

 

SOMATOSAN

Geman Remedies

INJ

2mg

1ml

3710.00

SOMATOSTATIN UCB

UCB Pharma

INJ

(Somatostatin (as acetate hydrate) 3mg per vial suppplied with an ampoule containing Nacl 0.9% in 1ml water for inj.)
3mg

vial

3675.00

INJ

Somatostatin (as acetate hydrate) 250mcg
3mg per vial suppplied with an ampoule containing Nacl 0.9% in1ml water for inj.)
3mg

vial

590.00

STILAMIN

Serum Institute

AMP

250mcg

1

679.95

AMP

3mg

1

3993.42

TOP

                                                                                                    

 

By |2022-07-20T16:41:34+00:00July 20, 2022|Uncategorized|Comments Off on Somatostatin

About the Author: