Drug Information

 


 

Streptokinase

 











 

Pharmacokinetics.

 

It combines with the pro-activator of plasminogen and catalyzes the
conversion of inactive plasminogen to activates plasmin.


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Indication
& Dosage


 


IV/Intracoraonary

ACUTE MYOCARDIALINFARCION:


1.5 million units over 30-60 min IV or intracoronary-250000-300000 units
over 30-60 mins.


IV

DEEP VEIN THROMBOSIS, ARTERIAL OCCLUSIONS AND PULMONARY EMBOLISM:
250000
units intially by IV infusion in 100-300ml of physilogical saline given
over 30-60 min.

Maintenance 100000 units hrly for 3 days.


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Action

 



Forms a complex with plasminogen which then converts
plaminogen to plasmin. Plasmin breaks down clots as well as fibrinogen
and other plasma proteins.


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Interaction

 

Aspirin, Cefamandole, Divalproex,
Enoxaparin, Heparin, Indomethacin, anti-inflammatory drugs or analgesics
(except narcotics), Phenylbutazone, Plicamycin, Sulfinpyrazone,
Ticlopidine or Valproic acid: when used together with Streptokinase
increases the chances of bleeding .


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Adverse Effect
& Precautions



 


Fever, allergic reactions, bleeding
from different sites, rarely anaphylaxis, arrhythmias, bronochospasm.

Allergies:
Allergic reaction to streptokinase may occur. Pregnancy :There is a
slight chance that use of a thrombolytic agent during the first five
months of pregnancy may cause a miscarriage. Older adults: The need for
treatment with a thrombolytic agent may be increased in elderly patients
with blood clots, however, the chance of bleeding may also be increased.

Pregnancy: May cause premature separation of placenta in first 18 weeks.
Use only if clearly indicated.

Breast Feeding: Use with caution.

Man: Use with caution.


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Brands
available in market


 


























ESKINASE

Dabur
INJ 0.75m.i.u VIAL 1900.00
INJ 1.5m.i.u VIAL 3400.00
KABIKINASE

Pharmacia & Upjohn
VIAL 0.7 miu

1343.00
VIAL 1.5 miu

2307.00
STRFPTASE

Hoechst Marion Roussel
VIAL 250000 iu

544.00
VIAL 750000 iu

1961.00
VIAL 1500000 iu

3497.00
STREPTOKINASE INJ

Win-Medicare
INJ 750000 iu 1VIAL 1700.00
INJ 1500000 iu 1VIAL 3360.00
THROMBOSOLV

VHB
INJ 750000 iu VIAL 1695.00
INJ 1500000 iu VIAL 3093.00
ZYKINASE

Indon
INJ 0.75m.i.u VIAL 2178.00
INJ 1.5m.i.u VIAL 3898.09




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Drug Information
 

 
Streptokinase
 

 
Pharmacokinetics.
 
It combines with the pro-activator of plasminogen and catalyzes the conversion of inactive plasminogen to activates plasmin.

TOP
  

Indication & Dosage
 
IV/Intracoraonary
ACUTE MYOCARDIALINFARCION:

1.5 million units over 30-60 min IV or intracoronary-250000-300000 units over 30-60 mins.
IV
DEEP VEIN THROMBOSIS, ARTERIAL OCCLUSIONS AND PULMONARY EMBOLISM:
250000 units intially by IV infusion in 100-300ml of physilogical saline given over 30-60 min.
Maintenance 100000 units hrly for 3 days.

TOP
  

Action
 

Forms a complex with plasminogen which then converts plaminogen to plasmin. Plasmin breaks down clots as well as fibrinogen and other plasma proteins.

TOP
  

Interaction
 
Aspirin, Cefamandole, Divalproex, Enoxaparin, Heparin, Indomethacin, anti-inflammatory drugs or analgesics (except narcotics), Phenylbutazone, Plicamycin, Sulfinpyrazone, Ticlopidine or Valproic acid: when used together with Streptokinase increases the chances of bleeding .

TOP
  

Adverse Effect & Precautions
 
Fever, allergic reactions, bleeding from different sites, rarely anaphylaxis, arrhythmias, bronochospasm.

Allergies: Allergic reaction to streptokinase may occur. Pregnancy :There is a slight chance that use of a thrombolytic agent during the first five months of pregnancy may cause a miscarriage. Older adults: The need for treatment with a thrombolytic agent may be increased in elderly patients with blood clots, however, the chance of bleeding may also be increased.
Pregnancy: May cause premature separation of placenta in first 18 weeks. Use only if clearly indicated.
Breast Feeding: Use with caution.
Man: Use with caution.

TOP
  

ESKINASE

Dabur

INJ

0.75m.i.u

VIAL

1900.00

INJ

1.5m.i.u

VIAL

3400.00

KABIKINASE

Pharmacia & Upjohn

VIAL

0.7 miu

1343.00

VIAL

1.5 miu

2307.00

STRFPTASE

Hoechst Marion Roussel

VIAL

250000 iu

544.00

VIAL

750000 iu

1961.00

VIAL

1500000 iu

3497.00

STREPTOKINASE INJ

Win-Medicare

INJ

750000 iu

1VIAL

1700.00

INJ

1500000 iu

1VIAL

3360.00

THROMBOSOLV

VHB

INJ

750000 iu

VIAL

1695.00

INJ

1500000 iu

VIAL

3093.00

ZYKINASE

Indon

INJ

0.75m.i.u

VIAL

2178.00

INJ

1.5m.i.u

VIAL

3898.09

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By |2022-07-20T16:44:54+00:00July 20, 2022|Uncategorized|Comments Off on Streptokinase

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