Drug Informaiton

   


     











 

Pharmacokinetics.

After
administration it is rapidly hydrolysed by butrycholine esterase of
liver and plasma. Patient who show prolonged apnoea after
succinylcholine administration have atypical plsama cholinesterase or
deficiency of enzyme due to genetic factor.

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Indication
& Dosage




IV Infusion

AS ADJUNCT TO GENERAL ANAESTHESIA TO FACILITATE ENDOTRACHEAL INTUBATIION
AND/OR SKELETAL MUSCLE RELAXATION:
Highly variable. Average range for
adults 2.5-4.3mg/min as IV infusion of solution containing 1-2mg/ml of
the drug.

IV Bolus

EMERGENCY TRACHEAL INTUBATION IN CHILDREN:
Infants and small children:
2mg/kg. Older children and adolescents: 1mg/kg. IV bolus with extreme
care.





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Action



An ultrashort acting depolarsing type skeletal muscle
relaxant. Block the neuromucular junction by combining with the
cholinergic receptors and depolarising them. Onset of flaccid paralysis
is rapic(less than 1 min) and lasts for about 4-6 min after IV
administration. No action on  smooth muscle or uterus. No effect on
consciousness, pain.

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Interaction

 

Diazepam: Reduces duration of
neuromuscular blockade produced by succinylcholine.

Phenelzine, Promazine, Oxytocin, certain Non-penicillin antibiotics,
Quinidine, betablockers, Procainamide, Lidocaine, Trimethaphan, Lithium
carbonate, Furosemide, Magnesium sulphate, Quinine, Chloroquine,
Acetylcholine, Anticholinesterases, Procaine type local anaesthetics and
isoflurance: May enhance the efficacy of succinycholine.

Amphotericin B and Thiazide diuretics: Electrolyte imbalances caused by
these rusult in increased effects of succinylcoline. Cyclophsophamide,
IV procaine: Prolong the effects of succinylcholine.

Digitals glycosides: Toxicity of both drug may be increased. Inhalation
anaesthetics (e.g cyclopropane, diethylether, halothane and nitrous
oxide): increased incidence of bradycardia, arrhythmias, sinus arrest
thermia may occur in susceptible individual.

Narcotic analgesics: Increased incidence of bradycardia and caridiac
arrest.



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Adverse
Effect & Precautions






Hyperkalaemia- related cardiac
arrest, muscle pain. Respiratory depressionor apnoea, malignant
hypethermia, excessive salivation, myoglobinuria, rise in intraocular
pressure, tachycardia or bradycardia. Serious histamine mediated
flushing, broncho-constriction and hypotension are uncommon in normal
clinical usage.



Precaution: Renal or hepatic failure, myasthenia graves. repeated
injection can cause bradycardia, extra-systoles, other cardiac
irregularities.

Pregnancy: Use with caution.

Breast Feeding: Use with caution.

Man: May be used.

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Brands
available in market


 

















MIDARINE

Burroughs Wellcome

INJ

50mg/ml

2ml

9.63

SCOLINE

Glaxo Pharma

INJ

50mg/ml

2ml

8.65

SUXOMIN

VHB

INJ

50mg/ml

10ml

31.00



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Drug Informaiton
   

     

 
Pharmacokinetics.

After administration it is rapidly hydrolysed by butrycholine esterase of liver and plasma. Patient who show prolonged apnoea after succinylcholine administration have atypical plsama cholinesterase or deficiency of enzyme due to genetic factor.

TOP
  

Indication & Dosage

IV Infusion
AS ADJUNCT TO GENERAL ANAESTHESIA TO FACILITATE ENDOTRACHEAL INTUBATIION AND/OR SKELETAL MUSCLE RELAXATION:
Highly variable. Average range for adults 2.5-4.3mg/min as IV infusion of solution containing 1-2mg/ml of the drug.

IV Bolus
EMERGENCY TRACHEAL INTUBATION IN CHILDREN:
Infants and small children: 2mg/kg. Older children and adolescents: 1mg/kg. IV bolus with extreme care.


TOP
   

Action

An ultrashort acting depolarsing type skeletal muscle relaxant. Block the neuromucular junction by combining with the cholinergic receptors and depolarising them. Onset of flaccid paralysis is rapic(less than 1 min) and lasts for about 4-6 min after IV administration. No action on  smooth muscle or uterus. No effect on consciousness, pain.

TOP
  

Interaction
 
Diazepam: Reduces duration of neuromuscular blockade produced by succinylcholine.
Phenelzine, Promazine, Oxytocin, certain Non-penicillin antibiotics, Quinidine, betablockers, Procainamide, Lidocaine, Trimethaphan, Lithium carbonate, Furosemide, Magnesium sulphate, Quinine, Chloroquine, Acetylcholine, Anticholinesterases, Procaine type local anaesthetics and isoflurance: May enhance the efficacy of succinycholine.
Amphotericin B and Thiazide diuretics: Electrolyte imbalances caused by these rusult in increased effects of succinylcoline. Cyclophsophamide, IV procaine: Prolong the effects of succinylcholine.
Digitals glycosides: Toxicity of both drug may be increased. Inhalation anaesthetics (e.g cyclopropane, diethylether, halothane and nitrous oxide): increased incidence of bradycardia, arrhythmias, sinus arrest thermia may occur in susceptible individual.
Narcotic analgesics: Increased incidence of bradycardia and caridiac arrest.


TOP
   

Adverse Effect & Precautions

Hyperkalaemia- related cardiac arrest, muscle pain. Respiratory depressionor apnoea, malignant hypethermia, excessive salivation, myoglobinuria, rise in intraocular pressure, tachycardia or bradycardia. Serious histamine mediated flushing, broncho-constriction and hypotension are uncommon in normal clinical usage.

Precaution: Renal or hepatic failure, myasthenia graves. repeated injection can cause bradycardia, extra-systoles, other cardiac irregularities.
Pregnancy: Use with caution.
Breast Feeding: Use with caution.
Man: May be used.

TOP
    

MIDARINE

Burroughs Wellcome

INJ

50mg/ml

2ml

9.63

SCOLINE

Glaxo Pharma

INJ

50mg/ml

2ml

8.65

SUXOMIN

VHB

INJ

50mg/ml

10ml

31.00

TOP

                                              

 

By |2022-07-20T16:44:58+00:00July 20, 2022|Uncategorized|Comments Off on Succinylcholine

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