After administration it is rapidly hydrolysed by butrycholine esterase of liver and plasma. Patient who show prolonged apnoea after succinylcholine administration have atypical plsama cholinesterase or deficiency of enzyme due to genetic factor.
AS ADJUNCT TO GENERAL ANAESTHESIA TO FACILITATE ENDOTRACHEAL INTUBATIION AND/OR SKELETAL MUSCLE RELAXATION: Highly variable. Average range for adults 2.5-4.3mg/min as IV infusion of solution containing 1-2mg/ml of the drug.
EMERGENCY TRACHEAL INTUBATION IN CHILDREN: Infants and small children: 2mg/kg. Older children and adolescents: 1mg/kg. IV bolus with extreme care.
An ultrashort acting depolarsing type skeletal muscle relaxant. Block the neuromucular junction by combining with the cholinergic receptors and depolarising them. Onset of flaccid paralysis is rapic(less than 1 min) and lasts for about 4-6 min after IV administration. No action on smooth muscle or uterus. No effect on consciousness, pain.
Diazepam: Reduces duration of neuromuscular blockade produced by succinylcholine.
Phenelzine, Promazine, Oxytocin, certain Non-penicillin antibiotics, Quinidine, betablockers, Procainamide, Lidocaine, Trimethaphan, Lithium carbonate, Furosemide, Magnesium sulphate, Quinine, Chloroquine, Acetylcholine, Anticholinesterases, Procaine type local anaesthetics and isoflurance: May enhance the efficacy of succinycholine.
Amphotericin B and Thiazide diuretics: Electrolyte imbalances caused by these rusult in increased effects of succinylcoline. Cyclophsophamide, IV procaine: Prolong the effects of succinylcholine.
Digitals glycosides: Toxicity of both drug may be increased. Inhalation anaesthetics (e.g cyclopropane, diethylether, halothane and nitrous oxide): increased incidence of bradycardia, arrhythmias, sinus arrest thermia may occur in susceptible individual.
Narcotic analgesics: Increased incidence of bradycardia and caridiac arrest.
Effect & Precautions
Hyperkalaemia- related cardiac arrest, muscle pain. Respiratory depressionor apnoea, malignant hypethermia, excessive salivation, myoglobinuria, rise in intraocular pressure, tachycardia or bradycardia. Serious histamine mediated flushing, broncho-constriction and hypotension are uncommon in normal clinical usage.
Precaution: Renal or hepatic failure, myasthenia graves. repeated injection can cause bradycardia, extra-systoles, other cardiac irregularities.
Pregnancy: Use with caution.
Breast Feeding: Use with caution.
Man: May be used.