Drug Information

    

 










Pharmacokinetics

 

It is given orally, the drug has biphasic half life.

Top 

 

Indication
& Dosage


 


Oral

PALLIATIVE TREATMENT OF ADVANCED BREAST CANCER:
20-402mg/day in 2 divided doses.

Top 



 



Action


 

A nonsteroidal potent antioestrogen. It competes with oestradiol for
oestrogen receptor protein in target tissues. Actions are similar to
clomiphene

Top 

 



Interactions



Oral anticoagulants:
Significant increase in anticoagulant effect requiring careful
monitoring of prothrombin time.

Bromocriptine: Serum tamoxifen levels are elevated.

Cycolophophasmide: Since tamoxifen is potent inhibitor of
cytochrome p450 oxidase it may affect metabolism and excretion of
cylcophophamide.

Top 

 



Adverse
Effect & Precautions




Nausea,
vomiting, hot flushes, vaginal bleeding, dermatitis, pruritus
vulvae, menstrual irregularities.



Precaution: Premenopausal women.

Pregnancy: Contraindicated.

Breast Feeding: Use with caution.

Man: May be use.

Top 

 



Brands available in market :





























  

  

  

 


CYTOFEN

BDH

TAB

10mg

10

26.17

ELDTAM


 


 

ELDER

TAB

10mg

10

28.25

TAB

20mg

10

53.50

MAMOFEN


 


 

Khandelwal

TAB

10mg

10

29.21

ONCOMOX


 


 

T.D.P.L

TAB

10mg

10

15.50

ONCOTAM


 


 

Indon

TAB

10mg

10

29.19

TAB

20mg

10

49.32

TAMOFEN


 


 

Torrent

TAB

10mg

10

51.90

TAMOXIFEN


 


 

Dabur

TAB

20mg

10

31.20

TAB

10mg

10

18.95

TAMOXIFEN
LYKA


 


 

Lyka

TAB

10mg

10

29.00

TAB

20mg

10

49.00

TAMOXIFEN
TABS


 


 

Biochem

TAB

10mg

10

25.31

TEVAFEN


 


 

SPPL

TAB

10mg

10

28.00

TAB

20mg

10

55.00



Top 

 


                                                                                  
           






 

 

     
Drug Information
    

 

Pharmacokinetics
 
It is given orally, the drug has biphasic half life.

Top 

 

Indication & Dosage
 
Oral
PALLIATIVE TREATMENT OF ADVANCED BREAST CANCER: 20-402mg/day in 2 divided doses.

Top 

 

Action
 
A nonsteroidal potent antioestrogen. It competes with oestradiol for oestrogen receptor protein in target tissues. Actions are similar to clomiphene

Top 

 

Interactions

Oral anticoagulants: Significant increase in anticoagulant effect requiring careful monitoring of prothrombin time.
Bromocriptine: Serum tamoxifen levels are elevated.
Cycolophophasmide: Since tamoxifen is potent inhibitor of cytochrome p450 oxidase it may affect metabolism and excretion of cylcophophamide.

Top 

 

Adverse Effect & Precautions

Nausea, vomiting, hot flushes, vaginal bleeding, dermatitis, pruritus vulvae, menstrual irregularities.

Precaution: Premenopausal women.
Pregnancy: Contraindicated.
Breast Feeding: Use with caution.
Man: May be use.

Top 

 

Brands available in market :

  

  

  

 

CYTOFEN

BDH

TAB

10mg

10

26.17

ELDTAM

 

 

ELDER

TAB

10mg

10

28.25

TAB

20mg

10

53.50

MAMOFEN

 

 

Khandelwal

TAB

10mg

10

29.21

ONCOMOX

 

 

T.D.P.L

TAB

10mg

10

15.50

ONCOTAM

 

 

Indon

TAB

10mg

10

29.19

TAB

20mg

10

49.32

TAMOFEN

 

 

Torrent

TAB

10mg

10

51.90

TAMOXIFEN

 

 

Dabur

TAB

20mg

10

31.20

TAB

10mg

10

18.95

TAMOXIFEN LYKA

 

 

Lyka

TAB

10mg

10

29.00

TAB

20mg

10

49.00

TAMOXIFEN TABS

 

 

Biochem

TAB

10mg

10

25.31

TEVAFEN

 

 

SPPL

TAB

10mg

10

28.00

TAB

20mg

10

55.00

Top 
 

                                                                                              

 

By |2022-07-20T16:42:48+00:00July 20, 2022|Uncategorized|Comments Off on Tamoxifen

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