Drug Information

   

     










 

Pharmacokinetics




After oral administration it
is almost completely absorbed. It is highly bound to plasma proteins and
is metabolised in liver. About 10% Terazosin is excreted unchanged in
urine. It crosses the placenta

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Indication
& Dosage


 


Oral

HYPERTENSION:
Start with 1mg at bedtime. Dose can be doubled at weekly
intervals to get optimum reduction in BP. Usual maintenance is 2-10mg once
daily BPH: Similar dosage

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Action


 

Terazosin is an alpha-1 adrenoceptor antagonist with a longer duration
of action than prazosin. It reduces blood pressure with minimal effect on
heart rate. In the prostate terazosin reduces the vascular tone which is
the dynamic component is benign prostatic enlargement. Terazosin can
increase urinary flow rates in patients with benign prostatic hyperplasia
(BPH)

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Interactions



Clonidine: The
antihypertensive effects of clonidine may be decreased.





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Adverse
Effect & Precautions




Marked hypotension with
first dose of terazosin. Drowsiness, dizziness, nausea, blurred
vision, nasal congestion, peripheral oedema, syncopial episodes
and headache. In patients with BPH postural hypotension has been
reported more than in those with hypertension.



Precaution: Therapy should be started at a low dose givenjust
before bedtime, liver dysfunction.

Pregnancy: Safety not established.

Breast Feeding: Use with caution.

Man: Use with caution.

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Brands available in market :

























 

 


HYTRIN

 

 


Abbott


TAB


1mg


10


82.50


TAB


2mg


10


132.00


TAB


5mg


10


262.50


OLYSTER

  

 


Cadila Healthcare


TAB


1mg


10


83.02


TAB


2mg


10


132.00


TAB


5mg


10


262.50


TERALFA

 

 


Torrent


TAB


1mg


10


75.00


TAB


2mg


10


120.00


TAB


5mg


10


210.00


TERAPRESS

 

 


Intas


TABS


1mg


7


33.00


TABS


2mg


7


48.50


TABS


5mg


7


104.50


TERAZ


Unisearch

TAB


1mg


10


75.00


TABS


2mg


10


120.00


TABS


5mg


10


160.00









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Drug Information
   

     

 
Pharmacokinetics


After oral administration it is almost completely absorbed. It is highly bound to plasma proteins and is metabolised in liver. About 10% Terazosin is excreted unchanged in urine. It crosses the placenta

Top
   

Indication & Dosage
 
Oral
HYPERTENSION:
Start with 1mg at bedtime. Dose can be doubled at weekly intervals to get optimum reduction in BP. Usual maintenance is 2-10mg once daily BPH: Similar dosage

Top
   

Action
 
Terazosin is an alpha-1 adrenoceptor antagonist with a longer duration of action than prazosin. It reduces blood pressure with minimal effect on heart rate. In the prostate terazosin reduces the vascular tone which is the dynamic component is benign prostatic enlargement. Terazosin can increase urinary flow rates in patients with benign prostatic hyperplasia (BPH)

Top
    

Interactions

Clonidine: The antihypertensive effects of clonidine may be decreased.


Top
   

Adverse Effect & Precautions

Marked hypotension with first dose of terazosin. Drowsiness, dizziness, nausea, blurred vision, nasal congestion, peripheral oedema, syncopial episodes and headache. In patients with BPH postural hypotension has been reported more than in those with hypertension.

Precaution: Therapy should be started at a low dose givenjust before bedtime, liver dysfunction.
Pregnancy: Safety not established.
Breast Feeding: Use with caution.
Man: Use with caution.

Top

 

 
Brands available in market :

 

 

HYTRIN

 

 

Abbott

TAB

1mg

10

82.50

TAB

2mg

10

132.00

TAB

5mg

10

262.50

OLYSTER

  

 

Cadila Healthcare

TAB

1mg

10

83.02

TAB

2mg

10

132.00

TAB

5mg

10

262.50

TERALFA

 

 

Torrent

TAB

1mg

10

75.00

TAB

2mg

10

120.00

TAB

5mg

10

210.00

TERAPRESS

 

 

Intas

TABS

1mg

7

33.00

TABS

2mg

7

48.50

TABS

5mg

7

104.50

TERAZ

Unisearch

TAB

1mg

10

75.00

TABS

2mg

10

120.00

TABS

5mg

10

160.00



Top
         

                                                                                                    

 

By |2022-07-20T16:44:55+00:00July 20, 2022|Uncategorized|Comments Off on Terazosin

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