Drug Information

        


     











Pharmacokinetics




It is well absorbed from the
GI tract and is metabolised in the liver to inactive metabolites which
are excreted in the urine.

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Indication
& Dosage




Oral

FUNGAL INFECTIONS OF SKIN AND NAILS CAUSED BY DERMATOPHYTES SUCH AS
TRICHOPHYTON, MICROSPORUM CANIS, AND EPIDERMOPHYTON FLOCCUSUM AND FOR THE
TREATMENT OF RING WORM (TINEA SPP):
Adult: 250mg once daily, duration is
variable usually 2-6 weeks and in ONychomycosis 6-12 weeks.

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Action

Terbinafine is an allylamine antifungal active against many fungal
pathogens particularly dermatophtes. Like most other systemic antifungals
terbinafine acts at the fungal cell membrane where it reduces ergosterol
synthesis. Dermatophytes and other filamentous fungi are more susceptible
to terbinafine than yeast although the mycelial phase of candida is
susceptible. Terbinafine is active against Trypanosoma cruzi and
Leishmania mexicana.

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Interactions


Cimetidine: Terbinafine
clearance is decreased 33%.

Rifampicin: Tebinafine clearance is increased 100%.

Cyclosporine: Clearance of cyclosporine increased by 15%.

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Adverse
Effect & Precautions




Irritation,
burning, itching and dryness.



Precaution: If irritation develops discontinue treatment.

Pregnancy: Use only if clearly indicated.

Breast Feeding: Decided whether to discontinue nursing or drug.

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Brands available in market :










EXIFINE


DR.Reddy’s


TAB


125mg


4


86.00


TAB


250mg


4


156.00


LAMISIL


Novartis


TAB


250mg


14


1247.00




 

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Drug Information
        

     

Pharmacokinetics

It is well absorbed from the GI tract and is metabolised in the liver to inactive metabolites which are excreted in the urine.

Top
   

Indication & Dosage

Oral
FUNGAL INFECTIONS OF SKIN AND NAILS CAUSED BY DERMATOPHYTES SUCH AS TRICHOPHYTON, MICROSPORUM CANIS, AND EPIDERMOPHYTON FLOCCUSUM AND FOR THE TREATMENT OF RING WORM (TINEA SPP):
Adult: 250mg once daily, duration is variable usually 2-6 weeks and in ONychomycosis 6-12 weeks.

Top
   

Action

Terbinafine is an allylamine antifungal active against many fungal pathogens particularly dermatophtes. Like most other systemic antifungals terbinafine acts at the fungal cell membrane where it reduces ergosterol synthesis. Dermatophytes and other filamentous fungi are more susceptible to terbinafine than yeast although the mycelial phase of candida is susceptible. Terbinafine is active against Trypanosoma cruzi and Leishmania mexicana.

Top
   

Interactions

Cimetidine: Terbinafine clearance is decreased 33%.
Rifampicin: Tebinafine clearance is increased 100%.
Cyclosporine: Clearance of cyclosporine increased by 15%.

Top
   

Adverse Effect & Precautions

Irritation, burning, itching and dryness.

Precaution: If irritation develops discontinue treatment.
Pregnancy: Use only if clearly indicated.
Breast Feeding: Decided whether to discontinue nursing or drug.

Top
   

 
Brands available in market :

EXIFINE

DR.Reddy’s

TAB

125mg

4

86.00

TAB

250mg

4

156.00

LAMISIL

Novartis

TAB

250mg

14

1247.00

 

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By |2022-07-20T16:41:34+00:00July 20, 2022|Uncategorized|Comments Off on Terbinafine

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