DRUG
INFORMATION

     


       

Terbutaline

      










 

Pharmacokinetics

 

It is a selective Beta-2 adrenoreceptor agonist. It
is a potent bronchodilator. It can be given both orally as well as
parentrally. It is not a substrate for COMT, hence it has a long
duration of action of about 4-8 hours.

Top 

   

Indication
& Dosage


 


Oral

TO RELIEVE BRONCHIAL ASTHMA, CHRONIC BRONCHITIS AND EMPHYSEMA:
Adult:
2.5-5mg 2-3 times a day. 

CHILDREN: 7-15yrs-1.5-3mg. 3-6yrs-0.75-1.5mg. Under 3yrs-0/75mg. All 2-3
times a day.

Durules

TO RELIEVE BRONCHOSPASM IN BRONCHIAL ASTHAMA, CHRONIC BRONCHITIS AND
EMPHYSEMA: 
5-7.5mg b.i.d.




Inhalation

TO RELIEVE BRONCHOSPASM IN BRONCHIAL ASTHAMA, CHRONIC BRONCHITIS AND
EMPHYSEMA: Adult: 250-500mcg 3-4 times daily. Prophylaxis against
exercise-induced bronchspasm:
250-500mcg befor exercise.




SC, IM, Slow IV

ACUTE ASTHMA: Adult:
0.25mg upto 4 itmes/day. In severe cases 0.5mg may be
given.

Children: Over 2yrs 5-10mcg/kg. Max 300mcg/day in div doses.

Nebulising
Soln.

SEVERE ASTHMA:
5-10mg 2-4 times daily; additional doses n severe cases; 

children: upto 3yr:2mg, 3-6yr:3mg, 6-8yr:4mg, over 8yr: 5mg-all 2-4 times
a day.

Top 

       



Action


 

A beta adrenoceptor agonist wiht a selective action on beta 2
receptors. Main effect is bronchodilation, an increase of 15% or more in
FEV1. Significant reduction in airways and pulmonary resistance.

Top 

    




Interactions

Beta-blockers : These drugs reduce the effect
of the adrenergic bronchodilators. Cocaine, Ergoloid mesylates,
Ergotamine, Maprotiline, Tricyclic antidepressants : The effects
of these drugs on the heart and blood vessels may be potentiated.
Digitalis glycosides : The chance of Cardiac arrhythmias may be
increased. Monoamine oxidase (MAO) inhibitors : Using adrenergic
bronchodilators when using or within 2 weeks of taking monoamine
oxidase (MAO) inhibitors may increase the effects of MAO
inhibitors

Top 

      





Precautions

 



Precautions to be taken in patients with Brain damage,
Convulsions, Diabetes mellitus, Cardiac disease,Hypertension,
Hepatic dysfunction, Hyperthyroidism, Peptic ulcer,Pregnancy and
Pulmonary oedema.

Pregnancy: Safety not established, use only when clearly
indicated.

Breast Feeding: Use with caution.

Man: May be used in reduced dose.

Top 

      




 

Brands available in market :



















 

 


BRICANYL

 

 


Astra-IDL


TAB


2.5mg


20


10.60


TAB


5mg


20


17.10


SYRUP


1.5mg/5ml


100ml


17.10


INJ


0.5mg/ml


5x1ml


33.00


NEB-SOLN


10mg/ml


10ml


22.75


BRICANYL DURULES

  

  


Astra-IDL


TAB


5mg


10


10.50


TAB


7.5mg


10


14.00


BRICANYL INHALER

  

    


Astra-IDL


INHALER


250mcg/md


200(md)


10.50


INHALER


250mcg/md


200(md)


14.00


BRICANYL MISTHALER

  

 


Astra-IDL


INHALER


250mcg/md


200(md)


84.14




 

Top 

                                                     


                                               




 

 

                                 

       
DRUG INFORMATION
     

       
Terbutaline
      

 
Pharmacokinetics
 
It is a selective Beta-2 adrenoreceptor agonist. It is a potent bronchodilator. It can be given both orally as well as parentrally. It is not a substrate for COMT, hence it has a long duration of action of about 4-8 hours.

Top 
   

Indication & Dosage
 
Oral
TO RELIEVE BRONCHIAL ASTHMA, CHRONIC BRONCHITIS AND EMPHYSEMA:
Adult: 2.5-5mg 2-3 times a day. 
CHILDREN: 7-15yrs-1.5-3mg. 3-6yrs-0.75-1.5mg. Under 3yrs-0/75mg. All 2-3 times a day.

Durules
TO RELIEVE BRONCHOSPASM IN BRONCHIAL ASTHAMA, CHRONIC BRONCHITIS AND EMPHYSEMA: 
5-7.5mg b.i.d.

Inhalation
TO RELIEVE BRONCHOSPASM IN BRONCHIAL ASTHAMA, CHRONIC BRONCHITIS AND EMPHYSEMA: Adult: 250-500mcg 3-4 times daily. Prophylaxis against exercise-induced bronchspasm:
250-500mcg befor exercise.

SC, IM, Slow IV
ACUTE ASTHMA: Adult:
0.25mg upto 4 itmes/day. In severe cases 0.5mg may be given.
Children: Over 2yrs 5-10mcg/kg. Max 300mcg/day in div doses.

Nebulising Soln.
SEVERE ASTHMA:
5-10mg 2-4 times daily; additional doses n severe cases; 
children: upto 3yr:2mg, 3-6yr:3mg, 6-8yr:4mg, over 8yr: 5mg-all 2-4 times a day.

Top 
       

Action
 
A beta adrenoceptor agonist wiht a selective action on beta 2 receptors. Main effect is bronchodilation, an increase of 15% or more in FEV1. Significant reduction in airways and pulmonary resistance.

Top 
    

Interactions

Beta-blockers : These drugs reduce the effect of the adrenergic bronchodilators. Cocaine, Ergoloid mesylates, Ergotamine, Maprotiline, Tricyclic antidepressants : The effects of these drugs on the heart and blood vessels may be potentiated. Digitalis glycosides : The chance of Cardiac arrhythmias may be increased. Monoamine oxidase (MAO) inhibitors : Using adrenergic bronchodilators when using or within 2 weeks of taking monoamine oxidase (MAO) inhibitors may increase the effects of MAO inhibitors

Top 
      

Precautions
 

Precautions to be taken in patients with Brain damage, Convulsions, Diabetes mellitus, Cardiac disease,Hypertension, Hepatic dysfunction, Hyperthyroidism, Peptic ulcer,Pregnancy and Pulmonary oedema.
Pregnancy: Safety not established, use only when clearly indicated.
Breast Feeding: Use with caution.
Man: May be used in reduced dose.

Top 
      

 
Brands available in market :

 

 

BRICANYL

 

 

Astra-IDL

TAB

2.5mg

20

10.60

TAB

5mg

20

17.10

SYRUP

1.5mg/5ml

100ml

17.10

INJ

0.5mg/ml

5x1ml

33.00

NEB-SOLN

10mg/ml

10ml

22.75

BRICANYL DURULES

  

  

Astra-IDL

TAB

5mg

10

10.50

TAB

7.5mg

10

14.00

BRICANYL INHALER

  

    

Astra-IDL

INHALER

250mcg/md

200(md)

10.50

INHALER

250mcg/md

200(md)

14.00

BRICANYL MISTHALER

  

 

Astra-IDL

INHALER

250mcg/md

200(md)

84.14

 

Top 

                                                     
                                               

 

By |2022-07-20T16:44:55+00:00July 20, 2022|Uncategorized|Comments Off on Terbutaline

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