Drug
information

   





Tetracycline

   










Pharmacokinetics

 

Beta-blockers : These drugs reduce the effect of the adrenergic
bronchodilators. Cocaine, Ergoloid mesylates, Ergotamine, Maprotiline,
Tricyclic antidepressants : The effects of these drugs on the heart and
blood vessels may be potentiated. Digitalis glycosides : The chance of
Cardiac arrhythmias may be increased. Monoamine oxidase (MAO) inhibitors
: Using adrenergic bronchodilators when using or within 2 weeks of
taking monoamine oxidase (MAO) inhibitors may increase the effects of
MAO inhibitors

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Indication
& Dosage


 

Oral

INFECTIONS CAUSED BY SUSCEPTIBLE ORGANISMS:
1-2g/day in four divide doses

Top

  
 



Action


 

Bacteriostatic action through inhibition of protein synthesis.
Effective against a wide range of organisms including rickettsiae,
Mycoplasma pneumoniae, pathogens causing lymphogranuloma venerium and
granuloma inguinale, Borrelia recurrentis; Gram-negative organisms
including Haemophilus influenzae, H.ducreyi, Pasteurella pestis,
P.tulareniss, Bacteroides spp., Bartonella, Vibrio cholera, Brucella,
e.coli, Enterobacter, Klebsiella, Shigella; Gram-positives such as
Strep.pyogenes, Strep.faecalis, Diplococcus pneumoniae, Staph.aureus,
other pathogens such as Neisseria gonnorrhoeae, treponema pallidum,
T.pertenue (yams), Listeria monocytogenes, Clostridium, Bacillus anthracis,
Chlamydia trachomatis.

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Interactions

Interaction may occur with Antacids, Calcium
supplements, Cholestyramine, Choline and magnesium salicylates,
Colestipol, Iron-containing drugs, Laxatives, Magnesium salicylate:
these drugs may decrease the potency of tetracyclines. Oral
contraceptives containing estrogen: tetracyclines may decrease the
contraceptive effect and increase the chance of unwanted
pregnancy.

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Adverse
Effect & Precautions




Anorexia,
nausea, vomiting, epigastric distress, oesophageal ulcers, skin
rash, photosensitivity, fatty liver, urtcaria, anaphylaxis,
pseudotumor cerebri, neutropenia, superinfection, tooth
discoloration.


 

Patients with hepatic and renal disease may
have an increased chance of adverse effects if they use
tetracycline.

Pregnancy: Contraindicated.

Breast Feeding: Contraindicated.

Man: May be used.

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Brands available in market :





























ACHRONYCIN


Wyeth Lederle


CAPS


250mg


10


14.70


CAPS


250mg


400


415.00


HOSTACYCLINE


Hoechst Marion Roussel


CAPS


250mg


10


10.52


CAPS


500mg


24×4


20.68


IDILIN


IDPL


CAPS


250mg


10


11.88


CAPS


500mg


4


7.16


LINEMETT


Mercury


TAB


333mg


12×10


216.00


TAB


500mg


12×10


270.00


RESTECLIN


Sarabhai


CAPS/TAB


250mg


10


14.14


CAPS/TAB


250mg


4


9.54


SUBAMYCIN


Dey’s


CAPS


250mg


10


12.78


CAPLET


500mg


4


8.15


TETRACYCLINE


Dabur


CAPS


250mg


500


490.00


CAPS


250mg


10


15.72


CAPS


250mg


1000


1427.14


THREOCYCLINE


CAPS


333mg


6


8.80


Top



 

                                                                                            






 

  
Drug information
   


Tetracycline
   

Pharmacokinetics
 
Beta-blockers : These drugs reduce the effect of the adrenergic bronchodilators. Cocaine, Ergoloid mesylates, Ergotamine, Maprotiline, Tricyclic antidepressants : The effects of these drugs on the heart and blood vessels may be potentiated. Digitalis glycosides : The chance of Cardiac arrhythmias may be increased. Monoamine oxidase (MAO) inhibitors : Using adrenergic bronchodilators when using or within 2 weeks of taking monoamine oxidase (MAO) inhibitors may increase the effects of MAO inhibitors

Top
    

Indication & Dosage
 
Oral
INFECTIONS CAUSED BY SUSCEPTIBLE ORGANISMS:
1-2g/day in four divide doses

Top
  
 

Action
 
Bacteriostatic action through inhibition of protein synthesis. Effective against a wide range of organisms including rickettsiae, Mycoplasma pneumoniae, pathogens causing lymphogranuloma venerium and granuloma inguinale, Borrelia recurrentis; Gram-negative organisms including Haemophilus influenzae, H.ducreyi, Pasteurella pestis, P.tulareniss, Bacteroides spp., Bartonella, Vibrio cholera, Brucella, e.coli, Enterobacter, Klebsiella, Shigella; Gram-positives such as Strep.pyogenes, Strep.faecalis, Diplococcus pneumoniae, Staph.aureus, other pathogens such as Neisseria gonnorrhoeae, treponema pallidum, T.pertenue (yams), Listeria monocytogenes, Clostridium, Bacillus anthracis, Chlamydia trachomatis.

Top
   

Interactions

Interaction may occur with Antacids, Calcium supplements, Cholestyramine, Choline and magnesium salicylates, Colestipol, Iron-containing drugs, Laxatives, Magnesium salicylate: these drugs may decrease the potency of tetracyclines. Oral contraceptives containing estrogen: tetracyclines may decrease the contraceptive effect and increase the chance of unwanted pregnancy.

Top
    

Adverse Effect & Precautions

Anorexia, nausea, vomiting, epigastric distress, oesophageal ulcers, skin rash, photosensitivity, fatty liver, urtcaria, anaphylaxis, pseudotumor cerebri, neutropenia, superinfection, tooth discoloration.

 
Patients with hepatic and renal disease may have an increased chance of adverse effects if they use tetracycline.
Pregnancy: Contraindicated.
Breast Feeding: Contraindicated.
Man: May be used.

Top
  
 

Brands available in market :

ACHRONYCIN

Wyeth Lederle

CAPS

250mg

10

14.70

CAPS

250mg

400

415.00

HOSTACYCLINE

Hoechst Marion Roussel

CAPS

250mg

10

10.52

CAPS

500mg

24×4

20.68

IDILIN

IDPL

CAPS

250mg

10

11.88

CAPS

500mg

4

7.16

LINEMETT

Mercury

TAB

333mg

12×10

216.00

TAB

500mg

12×10

270.00

RESTECLIN

Sarabhai

CAPS/TAB

250mg

10

14.14

CAPS/TAB

250mg

4

9.54

SUBAMYCIN

Dey’s

CAPS

250mg

10

12.78

CAPLET

500mg

4

8.15

TETRACYCLINE

Dabur

CAPS

250mg

500

490.00

CAPS

250mg

10

15.72

CAPS

250mg

1000

1427.14

THREOCYCLINE

CAPS

333mg

6

8.80

Top

 

                                                                                            

 

By |2022-07-20T16:44:55+00:00July 20, 2022|Uncategorized|Comments Off on Tetracycline

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