Drug
information

  


    
 


Thiopentone

     










 

Pharmacokinetics



After administration it is
distributed intially in organs which are highly vascular e.g. Brain.
Subsequently the termination of its effect depends upon redistribution
of drug from brain to fatty tissues and other tissues.

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Indication
& Dosage






IV

AS ANAESTHETIC FOR OPERATIONS OF SHORT AND MEDIUM DURATION, CONTROL OF
STATUS EPILEPTICUS, ALCOHOLIC CONVULSIVE STATES: 

2.5% OR 5% solution.
Dosage to be individualised. Initially 100-150mg over 10-15 secs upto
4mg/kg if reqd.

Children: 2-7mg/kg for induction.

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Action


 

CNS depressant
inducing hypnosis and anaesthesia but not analgesia. Action sets in within
30-40 seconds of IV injections. Recovery is quick but repeated doses may
prolong anaesthesia. The drug is stored in fatty tissue and released
gradually.

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Interactions

Narcotics:
Those of phenobarbitone required to induce anaesthesia reduced.

Phenothiazines: Increased frequency and severity of neuromuscular
excitation and hypotension.


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Adverse
Effect & Precautions




Hypotension, hiccups,
apnoea for short period, nausea, vomiting.



Precaution: Thiopentone should not be mixed with succinylcholine
in the same syringe.

Precaution: Caution, use only when clearly indicated.

Breast Feeding: Use with caution.

Man: May be given in reduced dose.


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Brands available in market :

















ANESTHAL

 

 


Jagsonpal


INJ


500mg


VIAL


32.15


INJ


1g


VIA


49.50


INTRAVAL SODIUM

 

 


Rhone-Poulenc


INJ


500mg


50AMPS


1587.93


INJ


1g


50AMPS


2446.35


PENTOTHAL

 

 


Abbott


INJ


500mg


VIAL


26.41


INJ


1g


VIAL


40.69


THIOSOL

 

  


Neon Labs


INJ


500mg


1VIAL


35.28


INJ


1g


1VIAL


53.73


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Drug information
  

      
Thiopentone
     

 
Pharmacokinetics

After administration it is distributed intially in organs which are highly vascular e.g. Brain. Subsequently the termination of its effect depends upon redistribution of drug from brain to fatty tissues and other tissues.

Top
   

Indication & Dosage

IV
AS ANAESTHETIC FOR OPERATIONS OF SHORT AND MEDIUM DURATION, CONTROL OF STATUS EPILEPTICUS, ALCOHOLIC CONVULSIVE STATES: 
2.5% OR 5% solution. Dosage to be individualised. Initially 100-150mg over 10-15 secs upto 4mg/kg if reqd.
Children: 2-7mg/kg for induction.

Top 
   

Action
 
CNS depressant inducing hypnosis and anaesthesia but not analgesia. Action sets in within 30-40 seconds of IV injections. Recovery is quick but repeated doses may prolong anaesthesia. The drug is stored in fatty tissue and released gradually.

Top
  

Interactions

Narcotics: Those of phenobarbitone required to induce anaesthesia reduced.
Phenothiazines: Increased frequency and severity of neuromuscular excitation and hypotension.

Top  
    

Adverse Effect & Precautions

Hypotension, hiccups, apnoea for short period, nausea, vomiting.

Precaution: Thiopentone should not be mixed with succinylcholine in the same syringe.
Precaution: Caution, use only when clearly indicated.
Breast Feeding: Use with caution.
Man: May be given in reduced dose.

Top 
   

Brands available in market :

ANESTHAL

 

 

Jagsonpal

INJ

500mg

VIAL

32.15

INJ

1g

VIA

49.50

INTRAVAL SODIUM

 

 

Rhone-Poulenc

INJ

500mg

50AMPS

1587.93

INJ

1g

50AMPS

2446.35

PENTOTHAL

 

 

Abbott

INJ

500mg

VIAL

26.41

INJ

1g

VIAL

40.69

THIOSOL

 

  

Neon Labs

INJ

500mg

1VIAL

35.28

INJ

1g

1VIAL

53.73

Top

                                                                                                  

 

By |2022-07-20T16:42:49+00:00July 20, 2022|Uncategorized|Comments Off on Thiopentone

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