Drug
information

   




Thioridazine


   










Pharmacokinetics

 

The
pharmacokinetics of thioridazine appear to be generally similar to those
of chlorpromazine  The principal active metabolite of thioridazine
is mesoridazine  the metabolite, sulforidazine, also has some
activity. Thioridazine and its active metabolites are reported to be
highly bound to plasma proteins. The plasma half-life of thioridazine
has been estimated to range from about 6 to over 40 hours.

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Indication & Dosage



Anxiety, mixed anxiety
dpression, tension & agitation, psychosomatic disorders, emotional
distrubances. Geriatric senile agitation & confusional states.
Paediatrics: Additionally difficulty of concentration, behavioural
disorders, hyperactivity, aggressiveness

Dosage: Adult: Schizophrenia & Other psychoses: 150-600mg (initially
in divided doses): max. 800mg daily for upto 4 weeks. Severe anxiety and
agitation: 30-100mg daily.

Children: 1-5 year: 1mg/kg daily, 5-12 years: 75-150mg daily (upto 300mg
in severe cases).

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Interactions

 


The most common
interactions encountered with phenothiazines are adverse effects
resulting from concomitant administration of drugs with similar
pharmacological actions. When given with other drugs that produce
orthostatic hypotension dosage adjustments may be necessary.
However, it should be noted that phenothiazines have been reported
to reduce the antihypertensive action of guanethidine and other
adrenergic neurone blockers. As many phenothiazines possess
antimuscarinic actions they may potentiate the adverse effects of
other drugs with antimuscarinic actions, including tricyclic
antidepressants and the antimuscarinic antiparkinsonian drugs that
may be given to treat phenothiazine-induced extrapyramidal
effects. In theory, antipsychotics with dopamine-blocking activity
and dopaminergic drugs such as those used to treat parkinsonism
may be mutually antagonistic. Concomitant administration of
metoclopramide may increase the risk of antipsychotic-induced
extrapyramidal effects.

There is an
increased risk of arrhythmias when antipsychotics are used with
drugs which prolong the QT interval including certain
antiarrhythmics, antihistamines, antimalarials, and cisapride.
There is also an increased risk of arrhythmia when tricyclic
antidepressants are used with antipsychotics which prolong the QT
interval. Because of an increased risk of seizures the US
manufacturers recommend discontinuation of chlorpromazine before
the use of metrizamide for radiographic procedures. Symptoms of
CNS depression may be enhanced by other drugs with CNS-depressant
properties including alcohol, general anaesthetics, hypnotics,
anxiolytics, and opioids.






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Adverse
Effect &Precautions




Sedation,
drowsiness, interference with male sexual function, dry mouth,
blood dyscrasias, eye damage and hypersensitivity.



Precaution: Liver damage. Cardiovascular disease.

Pregnancy: Use with caution.

Breast Feeding: Use with caution.

Man: May be given in reduced dose.

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Brands available in market :


















 


 


 


 



ANESTHAL



 



Jagsonpal




INJ



500mg



VIAL



32.15



INJ



1g



VIA



49.50



INTRAVAL SODIUM



 


 



Rhone-Poulenc




INJ



500mg



50AMPS



1587.93



INJ



1g



50AMPS



2446.35



PENTOTHAL



 


 



Abbott




INJ



500mg



VIAL



26.41



INJ



1g



VIAL



40.69



THIOSOL



 


 



Neon Labs




INJ



500mg



1VIAL



35.28



INJ



1g



1VIAL



53.73


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Drug information
   


Thioridazine
   

Pharmacokinetics
 
The pharmacokinetics of thioridazine appear to be generally similar to those of chlorpromazine  The principal active metabolite of thioridazine is mesoridazine  the metabolite, sulforidazine, also has some activity. Thioridazine and its active metabolites are reported to be highly bound to plasma proteins. The plasma half-life of thioridazine has been estimated to range from about 6 to over 40 hours.

Top  

Indication & Dosage

Anxiety, mixed anxiety dpression, tension & agitation, psychosomatic disorders, emotional distrubances. Geriatric senile agitation & confusional states. Paediatrics: Additionally difficulty of concentration, behavioural disorders, hyperactivity, aggressiveness
Dosage: Adult: Schizophrenia & Other psychoses: 150-600mg (initially in divided doses): max. 800mg daily for upto 4 weeks. Severe anxiety and agitation: 30-100mg daily.
Children: 1-5 year: 1mg/kg daily, 5-12 years: 75-150mg daily (upto 300mg in severe cases).

Top  

Interactions
 
The most common interactions encountered with phenothiazines are adverse effects resulting from concomitant administration of drugs with similar pharmacological actions. When given with other drugs that produce orthostatic hypotension dosage adjustments may be necessary. However, it should be noted that phenothiazines have been reported to reduce the antihypertensive action of guanethidine and other adrenergic neurone blockers. As many phenothiazines possess antimuscarinic actions they may potentiate the adverse effects of other drugs with antimuscarinic actions, including tricyclic antidepressants and the antimuscarinic antiparkinsonian drugs that may be given to treat phenothiazine-induced extrapyramidal effects. In theory, antipsychotics with dopamine-blocking activity and dopaminergic drugs such as those used to treat parkinsonism may be mutually antagonistic. Concomitant administration of metoclopramide may increase the risk of antipsychotic-induced extrapyramidal effects.

There is an increased risk of arrhythmias when antipsychotics are used with drugs which prolong the QT interval including certain antiarrhythmics, antihistamines, antimalarials, and cisapride. There is also an increased risk of arrhythmia when tricyclic antidepressants are used with antipsychotics which prolong the QT interval. Because of an increased risk of seizures the US manufacturers recommend discontinuation of chlorpromazine before the use of metrizamide for radiographic procedures. Symptoms of CNS depression may be enhanced by other drugs with CNS-depressant properties including alcohol, general anaesthetics, hypnotics, anxiolytics, and opioids.


Top 
   

Adverse Effect &Precautions

Sedation, drowsiness, interference with male sexual function, dry mouth, blood dyscrasias, eye damage and hypersensitivity.

Precaution: Liver damage. Cardiovascular disease.
Pregnancy: Use with caution.
Breast Feeding: Use with caution.
Man: May be given in reduced dose.

Top 
  

Brands available in market :

 

 

 

 

ANESTHAL

 

Jagsonpal

INJ

500mg

VIAL

32.15

INJ

1g

VIA

49.50

INTRAVAL SODIUM

 

 

Rhone-Poulenc

INJ

500mg

50AMPS

1587.93

INJ

1g

50AMPS

2446.35

PENTOTHAL

 

 

Abbott

INJ

500mg

VIAL

26.41

INJ

1g

VIAL

40.69

THIOSOL

 

 

Neon Labs

INJ

500mg

1VIAL

35.28

INJ

1g

1VIAL

53.73

Top

 

                                                                                                           

 

By |2022-07-20T16:44:53+00:00July 20, 2022|Uncategorized|Comments Off on Thioridazine

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