When Ticlopidine is given orally it inhibits platelet aggregation induced by adenosine diphospate. It does not inhibit via cyclo-oxygenase pathway.
RISK REDUTION FOR RECURRENT TIAs AND STROKE, AND IN PATIENTS WITH UNSTABLE ANGINA AND PERIPHERAL VASUCLAR DISEASE. PREVENTIONOF REOCCLUSION AFTER CABG, AV SHUNTS. TO IMPROVE WALKING ABILITY AND INCREASE TIME FOR CLAUDICATON: Adult: 250mg b.i.d with or after meals.
Inhibits binding of fibrinogen to platelets. Other mechanisms also contribute to inhibition of thromboxane A2 formation. Thiclopidine also reduces whole blood viscosity.
The chance of serious bleeding may be increased with: Anticoagulants, Carbenicillin, Dipyridamole, Divalproex, Heparin, Anti-inflammatory drugs, Pentoxifylline, Plicamycin, Sulfinpyrazone, Ticarcillin and with Valproic acid.
Effect & Precautions
Nausea, vomiting, abominal pain, diarrhoea, neutropenia, skin rash, headache, tinnitus, rarely vertigo cholestatic jaundice, blood dyscrasias.
Precaution should be taken in Coagulation
defects ( such as hemophilia and Von Willebrand’s disease) and
Hepatic disease. Gastric ulcers: the chances of serious bleeding
may be increased. In Renal Impairment Ticlopidine is excreted from
the body more slowly, which may increase the chance of adverse
Breast Feeding: Contraindicated.