DRUG INFORMATION

    


     

Ticlopidine

    










Pharmacokinetics

 

When Ticlopidine is given orally it inhibits platelet
aggregation induced by adenosine diphospate. It does not inhibit via
cyclo-oxygenase pathway.

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Indication
& Dosage


 


Oral

RISK REDUTION FOR RECURRENT TIAs AND STROKE, AND IN PATIENTS WITH UNSTABLE
ANGINA AND PERIPHERAL VASUCLAR DISEASE. PREVENTIONOF REOCCLUSION AFTER
CABG, AV SHUNTS. TO IMPROVE WALKING ABILITY AND INCREASE TIME FOR
CLAUDICATON:
Adult: 250mg b.i.d with or after meals.

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Action


 


Inhibits binding of fibrinogen to platelets. Other mechanisms also
contribute to inhibition of thromboxane A2 formation. Thiclopidine also
reduces whole blood viscosity.

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Interactions

The chance of serious bleeding may be increased
with: Anticoagulants, Carbenicillin, Dipyridamole, Divalproex,
Heparin, Anti-inflammatory drugs, Pentoxifylline, Plicamycin,
Sulfinpyrazone, Ticarcillin and with Valproic acid.

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Adverse
Effect & Precautions




Nausea,
vomiting, abominal pain, diarrhoea, neutropenia, skin rash,
headache, tinnitus, rarely vertigo cholestatic jaundice, blood
dyscrasias.


Precaution should be taken in Coagulation
defects ( such as hemophilia and Von Willebrand’s disease) and
Hepatic disease. Gastric ulcers: the chances of serious bleeding
may be increased. In Renal Impairment Ticlopidine is excreted from
the body more slowly, which may increase the chance of adverse
effects.

Pregnancy: Contraindicated.

Breast Feeding: Contraindicated.

Man: Contraindicated.

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Brands available in market :

















BLOTHIN


Indipharma


FC-TABS


250mg


10


82.00


TICLOP


Cadila Healthcare


TAB


250mg


10


109.50


TICLOVAS


USV


TAB


250mg


10


95.00


TIKLEEN


IPCA


TAB


250mg


10


80.00


TILCONE


FDC


TAB


250mg


10


75.00


TYKLID


Torrent


TAB


250mg


10


159.90


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DRUG INFORMATION
    

     
Ticlopidine
    

Pharmacokinetics
 
When Ticlopidine is given orally it inhibits platelet aggregation induced by adenosine diphospate. It does not inhibit via cyclo-oxygenase pathway.

Top

 

Indication & Dosage
 
Oral
RISK REDUTION FOR RECURRENT TIAs AND STROKE, AND IN PATIENTS WITH UNSTABLE ANGINA AND PERIPHERAL VASUCLAR DISEASE. PREVENTIONOF REOCCLUSION AFTER CABG, AV SHUNTS. TO IMPROVE WALKING ABILITY AND INCREASE TIME FOR CLAUDICATON:
Adult: 250mg b.i.d with or after meals.

Top

 

Action
 
Inhibits binding of fibrinogen to platelets. Other mechanisms also contribute to inhibition of thromboxane A2 formation. Thiclopidine also reduces whole blood viscosity.

Top

 

Interactions

The chance of serious bleeding may be increased with: Anticoagulants, Carbenicillin, Dipyridamole, Divalproex, Heparin, Anti-inflammatory drugs, Pentoxifylline, Plicamycin, Sulfinpyrazone, Ticarcillin and with Valproic acid.

Top

 

Adverse Effect & Precautions

Nausea, vomiting, abominal pain, diarrhoea, neutropenia, skin rash, headache, tinnitus, rarely vertigo cholestatic jaundice, blood dyscrasias.

Precaution should be taken in Coagulation defects ( such as hemophilia and Von Willebrand’s disease) and Hepatic disease. Gastric ulcers: the chances of serious bleeding may be increased. In Renal Impairment Ticlopidine is excreted from the body more slowly, which may increase the chance of adverse effects.
Pregnancy: Contraindicated.
Breast Feeding: Contraindicated.
Man: Contraindicated.

Top

 

Brands available in market :

BLOTHIN

Indipharma

FC-TABS

250mg

10

82.00

TICLOP

Cadila Healthcare

TAB

250mg

10

109.50

TICLOVAS

USV

TAB

250mg

10

95.00

TIKLEEN

IPCA

TAB

250mg

10

80.00

TILCONE

FDC

TAB

250mg

10

75.00

TYKLID

Torrent

TAB

250mg

10

159.90

Top

 

                                                                                                          

 

By |2022-07-20T16:44:53+00:00July 20, 2022|Uncategorized|Comments Off on Ticlopidine

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