Drug
Information

  


   

Timolol

  










Pharmacokinetics

 

It is well absorbed after oral administration, extensively metabolised
in the liver with little unchanged drug appearing in the urine. Its
bioavailability is 50%.

Top

 

Indication
& Dosage




Topical Eye

CHRONIC OPEN ANGLE GLAUCOMA, INTRACOULAR HYPERTENSION, GLAUCOMA IN
PATIENTS WHO HAVE UNDERGONE TRABECULOPLASTY:
0.25% or 0.5% one drop twice
daily.

Top

 



Action

A non specific beta-1 and beta-2 adrenoceptor blocking agent. When
instilled into the eye, timolol reduces intraocular pressure. reduction of
IOP can be seen wihthin half an hour. There are little changes in pupil
size or accommodation. There isno blurred vision or night blindness which
is seen when pilocarpine is used.

Top

 



Interactions

It may increase the risk of serious allergic
reaction to these drugs: Aminophylline, Caffeine, Oxitriphylline,
Theophylline: the effects of both these drugs and beta-blockers
may be reduced; in addition, theophylline levels in the body may
be increased, especially in patients who smoke. Oral antidiabetics
or Insulin: There is an increased risk of hyperglycemia ;
beta-blockers may cover up certain symptoms of hypoglycemia such
as increases in pulse rate and blood pressure, and may make the
hypoglycemia last longer. Calcium channel blockers: bepridil,
diltiazem, felodipine, flunarizine, isradipine, nicardipine,
nifedipine, nimodipine, verapamil, clonidine, guanabenz : Effects
on blood pressure may be increased. Adverse effects may occur if
clonidine, guanabenz, or a beta-blocker is stopped suddenly after
use together. Adverse cardiac effects may occur when beta-blockers
are used with calcium channel blockers. Cocaine : Cocaine may
block the effects of beta-blockers; in addition, there is an
increased risk of Hypertension, tachcardia, and possibly cardiac
disorders if cocaine is used while taking a beta-blocker. With
Monoamine oxidase (MAO) inhibitors: Taking beta-blockers within 2
weeks of taking monoamine oxidase (MAO) inhibitors may cause
severe hypertension.

Top

 



Adverse
Effect & Precautions




Mild irritation,
transient burning sensation, may cause bronchospam. Visual
disturbances, cardiovascular and respiratory effects


 

Precaution should be taken during abrupt
reduction in dosage, pregnancy, lactation, elderly, IHD,CCF, renal
or hepatic dysfunction.

Pregnancy: Safety not established.

Breast Feeding: May be used.

Man: May be used.

Top

 



Brands available in market :





























GLAUCARE


Mejda


DROPS


0.25%


5ml


13.11


DROPS


0.5%


5ml


21.71


GLCOMOL


Torrent


SOLN


0.25%


5ml


16.90


SOLN


0.5%


5ml


27.90


GLUCOTIM


Centaur


DROPS


0.25%


5ml


12.50


DROPS


0.5%


5ml


19.62


IOTIM


FDC


DROPS


0.25%


5ml


14.20


DROPS


0.5%


5ml


24.05


IOTIM-UNIMS


FDC


DROPS


0.5%


6×0.5ml


23.00


OCOBAR


PCI


DROPS


0.25%


5ml


20.82


DROPS


0.5%


5ml


34.23


OCUPRES


Cadila Pharma


SOLN


2.5mg/ml


5ml


16.19


SOLN


5mg/ml


5ml


27.26


TIMOLET


Milmet


DROPS


0.25%


10ml


26.00


DROPS


0.5%


10ml


38.00






Top



 

                                                     


                                               






 

  
Drug Information
  

   
Timolol
  

Pharmacokinetics
 
It is well absorbed after oral administration, extensively metabolised in the liver with little unchanged drug appearing in the urine. Its bioavailability is 50%.

Top

 

Indication & Dosage

Topical Eye
CHRONIC OPEN ANGLE GLAUCOMA, INTRACOULAR HYPERTENSION, GLAUCOMA IN PATIENTS WHO HAVE UNDERGONE TRABECULOPLASTY:
0.25% or 0.5% one drop twice daily.

Top

 

Action

A non specific beta-1 and beta-2 adrenoceptor blocking agent. When instilled into the eye, timolol reduces intraocular pressure. reduction of IOP can be seen wihthin half an hour. There are little changes in pupil size or accommodation. There isno blurred vision or night blindness which is seen when pilocarpine is used.

Top

 

Interactions

It may increase the risk of serious allergic reaction to these drugs: Aminophylline, Caffeine, Oxitriphylline, Theophylline: the effects of both these drugs and beta-blockers may be reduced; in addition, theophylline levels in the body may be increased, especially in patients who smoke. Oral antidiabetics or Insulin: There is an increased risk of hyperglycemia ; beta-blockers may cover up certain symptoms of hypoglycemia such as increases in pulse rate and blood pressure, and may make the hypoglycemia last longer. Calcium channel blockers: bepridil, diltiazem, felodipine, flunarizine, isradipine, nicardipine, nifedipine, nimodipine, verapamil, clonidine, guanabenz : Effects on blood pressure may be increased. Adverse effects may occur if clonidine, guanabenz, or a beta-blocker is stopped suddenly after use together. Adverse cardiac effects may occur when beta-blockers are used with calcium channel blockers. Cocaine : Cocaine may block the effects of beta-blockers; in addition, there is an increased risk of Hypertension, tachcardia, and possibly cardiac disorders if cocaine is used while taking a beta-blocker. With Monoamine oxidase (MAO) inhibitors: Taking beta-blockers within 2 weeks of taking monoamine oxidase (MAO) inhibitors may cause severe hypertension.

Top

 

Adverse Effect & Precautions

Mild irritation, transient burning sensation, may cause bronchospam. Visual disturbances, cardiovascular and respiratory effects

 
Precaution should be taken during abrupt reduction in dosage, pregnancy, lactation, elderly, IHD,CCF, renal or hepatic dysfunction.
Pregnancy: Safety not established.
Breast Feeding: May be used.
Man: May be used.

Top

 

Brands available in market :

GLAUCARE

Mejda

DROPS

0.25%

5ml

13.11

DROPS

0.5%

5ml

21.71

GLCOMOL

Torrent

SOLN

0.25%

5ml

16.90

SOLN

0.5%

5ml

27.90

GLUCOTIM

Centaur

DROPS

0.25%

5ml

12.50

DROPS

0.5%

5ml

19.62

IOTIM

FDC

DROPS

0.25%

5ml

14.20

DROPS

0.5%

5ml

24.05

IOTIM-UNIMS

FDC

DROPS

0.5%

6×0.5ml

23.00

OCOBAR

PCI

DROPS

0.25%

5ml

20.82

DROPS

0.5%

5ml

34.23

OCUPRES

Cadila Pharma

SOLN

2.5mg/ml

5ml

16.19

SOLN

5mg/ml

5ml

27.26

TIMOLET

Milmet

DROPS

0.25%

10ml

26.00

DROPS

0.5%

10ml

38.00


Top

 

                                                     
                                               

 

By |2022-07-20T16:44:30+00:00July 20, 2022|Uncategorized|Comments Off on Timolol

About the Author: