Drug
Information

   


     

Tobramycin

     










   

Pharmacokinetics



It is given by potential route.


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Indication
& Dosage


 


IM/IV

SERIOUS INFECTIONS CAUSED BY SUSCEPTIBLE ORGANISMS, SEPTICAEMIA IN
NEONATES, LOWER RESPIRATORY TRACT INFECTIONS, MENINGITIS,INTRA-ABDOMINAL
INFECTIONS INCLUDING PERITONITS, SKIN, BONE AND SOFT TISSUE INFECTIONS,
COMPLICATED UTI:
Adults (Normal renal function): 3mg/kg/day in 3 equal
doses 8 hrly. Children:6-7.5mg/kg/day in 3-4 equally divided doses given 6
or 8 hrly. Premature or full term neonates of 1 week or less. Upto
4mg/kg/day in 2 equal doses 12hrly. Treatment is given for 7 days. Renal
impairment: Loading dose of 1mg/kg. Followed by: (1) Normal dose divided
by serum creatinine values given at the standard intervals. (2) Normal
dose given at intervals obtained by multiplying serum creatinine value by
6.


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Action


 

Bactericdal action through inhibition of protein synthesis. It is
active against Stap.aureus; E.coli, Enterobacter, Klebsiella, Morganella,
Pseudomona aeruginosa, Proteus mirabilis, P.vulgaris, Providencia spp,
Serratia spp, Citrobacter spp. It less active against most Gram-positive
organisms including Strep.pyogenes, Strep.pneumoniae and Entercoccus.


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Interactions

 

Concurrent use of other
nephrotoxic drugs, including other aminoglycosides, vancomycin,
some of the cephalosporins, cyclosporin, and cisplatin, or
potentially ototoxic drugs such as ethacrynic acid and perhaps
frusemide, may increase the risk of aminoglycoside toxicity. It
has been suggested that concurrent use of an antiemetic such as
dimenhydrinate may mask the early symptoms of vestibular
ototoxicity. Care is also required if other drugs with a
neuromuscular blocking action are given Comitantly.

Theneuromuscular blocking properties of aminoglycoside may be
sufficient to provoke severe respiratory depression in patients
receiving general anaesthetics or opioids.There is a theoretical
possibility that the antibacterial effects of aminoglycosides
could be reduced by use with a bacteriostatic antibacterial, but
such combinations have been used successfully in practice.

Since aminoglycosides have been shown to be incompatible with some
beta lactams in vitro these antibacterials should be administered
separately if both are required; antagonism in vivo has been
reported only in a few patients with severe renal impairment, in
whom aminoglycoside activity was diminished. Aminoglycosides
exhibit synergistic activity with a number of beta lactams in
vivo.


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Adverse
Effect & Precautions




Skin rash,
ototoxicity, nephrotoxicity, phlebitis, nausea, vomiting,
uritcaria, headache, fever.



Precaution: Renal impairment, prolonged use to bevoided,
denhydration, ensure adequate hydration.

Pregnancy: Contraindicated.

Breast Feeding: Use with caution.

Man: May be used in reduced dose.


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Brands available in market :

















TOBACIN


Aristo


VIAL


60mg


Vial


21.36


VIAL


80mg


Vial


26.93


INJ


20mg


Vial


11.15


TOBRANEG


Eli Lilly Ranbaxy


INJ


10mg


AMP


7.40


INJ


20mg


10 VIAL


19.90


INJ


40mg


AMP


17.00


INJ


60mg


10 VIAL


26.53


INJ


80mg


10 VIAL


31.70









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Drug Information
   

     
Tobramycin
     

   
Pharmacokinetics

It is given by potential route.

Top
  

Indication & Dosage
 
IM/IV
SERIOUS INFECTIONS CAUSED BY SUSCEPTIBLE ORGANISMS, SEPTICAEMIA IN NEONATES, LOWER RESPIRATORY TRACT INFECTIONS, MENINGITIS,INTRA-ABDOMINAL INFECTIONS INCLUDING PERITONITS, SKIN, BONE AND SOFT TISSUE INFECTIONS, COMPLICATED UTI:
Adults (Normal renal function): 3mg/kg/day in 3 equal doses 8 hrly. Children:6-7.5mg/kg/day in 3-4 equally divided doses given 6 or 8 hrly. Premature or full term neonates of 1 week or less. Upto 4mg/kg/day in 2 equal doses 12hrly. Treatment is given for 7 days. Renal impairment: Loading dose of 1mg/kg. Followed by: (1) Normal dose divided by serum creatinine values given at the standard intervals. (2) Normal dose given at intervals obtained by multiplying serum creatinine value by 6.

Top
  

Action
 
Bactericdal action through inhibition of protein synthesis. It is active against Stap.aureus; E.coli, Enterobacter, Klebsiella, Morganella, Pseudomona aeruginosa, Proteus mirabilis, P.vulgaris, Providencia spp, Serratia spp, Citrobacter spp. It less active against most Gram-positive organisms including Strep.pyogenes, Strep.pneumoniae and Entercoccus.

Top
   

Interactions
 
Concurrent use of other nephrotoxic drugs, including other aminoglycosides, vancomycin, some of the cephalosporins, cyclosporin, and cisplatin, or potentially ototoxic drugs such as ethacrynic acid and perhaps frusemide, may increase the risk of aminoglycoside toxicity. It has been suggested that concurrent use of an antiemetic such as dimenhydrinate may mask the early symptoms of vestibular ototoxicity. Care is also required if other drugs with a neuromuscular blocking action are given Comitantly.
Theneuromuscular blocking properties of aminoglycoside may be sufficient to provoke severe respiratory depression in patients receiving general anaesthetics or opioids.There is a theoretical possibility that the antibacterial effects of aminoglycosides could be reduced by use with a bacteriostatic antibacterial, but such combinations have been used successfully in practice.
Since aminoglycosides have been shown to be incompatible with some beta lactams in vitro these antibacterials should be administered separately if both are required; antagonism in vivo has been reported only in a few patients with severe renal impairment, in whom aminoglycoside activity was diminished. Aminoglycosides exhibit synergistic activity with a number of beta lactams in vivo.

Top
   

Adverse Effect & Precautions

Skin rash, ototoxicity, nephrotoxicity, phlebitis, nausea, vomiting, uritcaria, headache, fever.

Precaution: Renal impairment, prolonged use to bevoided, denhydration, ensure adequate hydration.
Pregnancy: Contraindicated.
Breast Feeding: Use with caution.
Man: May be used in reduced dose.

Top
   

Brands available in market :

TOBACIN

Aristo

VIAL

60mg

Vial

21.36

VIAL

80mg

Vial

26.93

INJ

20mg

Vial

11.15

TOBRANEG

Eli Lilly Ranbaxy

INJ

10mg

AMP

7.40

INJ

20mg

10 VIAL

19.90

INJ

40mg

AMP

17.00

INJ

60mg

10 VIAL

26.53

INJ

80mg

10 VIAL

31.70


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By |2022-07-20T16:42:48+00:00July 20, 2022|Uncategorized|Comments Off on Tobramycin

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