Drug Information


 


   

Tramadol


 










 

Pharmacokinetics

Tramadol is
readily absorbed following oral administration but is subject to
first-pass metabolism. Tramadol is metabolised by N- and O-demethylation
and glucuronidation or sulphation in the liver. The metabolite O-desmethyltramadol
is pharmacologically active. Tramadol is excreted mainly in the urine
predominantly as metabolites. Tramadol is widely distributed, crosses
the placenta, and appears in small amounts in breast milk. The
elimination half-life following oral administration is about 6 hours.

Top

  

Indication
& Dosage




Oral

MODERATE TO SEVERE PAIN & POST-OP. PAIN:
50-100mg 3-4 times daily.




SC/IM/IV

SEVERE ACUTE OR CHRONIC PAIN, CANCER PAIN, POST OPERATIVE PAIN:
Adult and
adolscents over 14 yrs: Single dose 100mg given sc, im or slow IV bolus or
infusion. Maximum daily dose. 400mg. Children: 1-1.5mg/kg.

NOTE: Renal or hepatic impairment may require dose reduction.

Top

 



Action

Tramadol acts a weak agonist at all types of opioid receptors with some
selectivity for the nu-receptors. It has excellent analgesic activity but
little repiratory depression or gatrointestinal effects. Tolerance to the
analgesic effect does not develop during prolonged therapy and there is no
dependence.

Top

 



Interactions



Carbamazepine: A
significant increase in Tramadol metabolism.

Hypnotics, Tranquilizers and other CNS depressants: Sedative
effects potentiated.

MAOIs: Fatal interaction occurs. Opioid analgesics like
Buprenorphine, Butorphanol and Pentazocine: May precipitate
withdrawal symptoms.

Tranquilzers: Analgesia potentiated.






Top


 



Adverse
Effect & Precautions




Nausea, vomiting
and dizziness.



Precaution: Alcohol. Not to drive and operate machinery.

Pregnancy: Safety not established.

Breast Feeding: Safety not established.

Man: May be given in reduced dose.




Top



Brands available in market :











































ADAMON


German Remedies


CAPS


50mg


10


51.00


INJ


100mg/2ml


2ml


20.40


INJ


50mg/ml


1ml


12.50


CONTRAMAL


SPPL


CAPS


50mg


1×10


60.32


INJ


50mg


1ml


13.07


INJ


50mg/ml


2ml


19.50


CONTRAMAL DT


SPPL


DISP TAB


50mg


10


65.00


CONTRAMAL-SR


SPPL


DISP TAB


100mg


10


140.74


DOLOTRAM


Sun Pharma


INJ


50mg/ml


1ml amp


13.00


CAPS


50mg


10


50.00


NOBLIGAN


Sarabhai


TAB


50mg


10


57.73


INJ


50mg/ml


1ml amp


13.05


INJ


100mg


2ml amp


24.11


SR TAB


100mg


10


141.11


ORCHIDOL


Orchid


TAB


50mg


10


50.00


inj


50mg/ml


2ml


24.00


INJ


50mg/ml


1ml amp


13.00


TRAMAZAC


Cadila Healthcare


CAPS


50mg


10


53.74


INJ


50mg


1ml


12.58


TRAMAZAC 100


Cadila Healthcare


INJ


100mg/ml


2ml


24.16


TRAMOL


Prem Pharma


INJ


50mg/ml


1ml AMP


15.00


INJ


50mg/ml


2ml AMP


24.00


TRASIC


Kopran


CAPS


50mg


10


54.00


TRD-CONTIN 100


Modi Mundipharma


CR TAB 


100mg


10


105.15


INJ


50mg/ml


1 AMP


13.00








Top



 

                                                     


                                               






 


Drug Information
 

   
Tramadol
 

 
Pharmacokinetics

Tramadol is readily absorbed following oral administration but is subject to first-pass metabolism. Tramadol is metabolised by N- and O-demethylation and glucuronidation or sulphation in the liver. The metabolite O-desmethyltramadol is pharmacologically active. Tramadol is excreted mainly in the urine predominantly as metabolites. Tramadol is widely distributed, crosses the placenta, and appears in small amounts in breast milk. The elimination half-life following oral administration is about 6 hours.

Top

  

Indication & Dosage

Oral
MODERATE TO SEVERE PAIN & POST-OP. PAIN:
50-100mg 3-4 times daily.

SC/IM/IV
SEVERE ACUTE OR CHRONIC PAIN, CANCER PAIN, POST OPERATIVE PAIN:
Adult and adolscents over 14 yrs: Single dose 100mg given sc, im or slow IV bolus or infusion. Maximum daily dose. 400mg. Children: 1-1.5mg/kg.
NOTE: Renal or hepatic impairment may require dose reduction.

Top

 

Action

Tramadol acts a weak agonist at all types of opioid receptors with some selectivity for the nu-receptors. It has excellent analgesic activity but little repiratory depression or gatrointestinal effects. Tolerance to the analgesic effect does not develop during prolonged therapy and there is no dependence.

Top

 

Interactions

Carbamazepine: A significant increase in Tramadol metabolism.
Hypnotics, Tranquilizers and other CNS depressants: Sedative effects potentiated.
MAOIs: Fatal interaction occurs. Opioid analgesics like Buprenorphine, Butorphanol and Pentazocine: May precipitate withdrawal symptoms.
Tranquilzers: Analgesia potentiated.


Top

 

Adverse Effect & Precautions

Nausea, vomiting and dizziness.

Precaution: Alcohol. Not to drive and operate machinery.
Pregnancy: Safety not established.
Breast Feeding: Safety not established.
Man: May be given in reduced dose.


Top

Brands available in market :

ADAMON

German Remedies

CAPS

50mg

10

51.00

INJ

100mg/2ml

2ml

20.40

INJ

50mg/ml

1ml

12.50

CONTRAMAL

SPPL

CAPS

50mg

1×10

60.32

INJ

50mg

1ml

13.07

INJ

50mg/ml

2ml

19.50

CONTRAMAL DT

SPPL

DISP TAB

50mg

10

65.00

CONTRAMAL-SR

SPPL

DISP TAB

100mg

10

140.74

DOLOTRAM

Sun Pharma

INJ

50mg/ml

1ml amp

13.00

CAPS

50mg

10

50.00

NOBLIGAN

Sarabhai

TAB

50mg

10

57.73

INJ

50mg/ml

1ml amp

13.05

INJ

100mg

2ml amp

24.11

SR TAB

100mg

10

141.11

ORCHIDOL

Orchid

TAB

50mg

10

50.00

inj

50mg/ml

2ml

24.00

INJ

50mg/ml

1ml amp

13.00

TRAMAZAC

Cadila Healthcare

CAPS

50mg

10

53.74

INJ

50mg

1ml

12.58

TRAMAZAC 100

Cadila Healthcare

INJ

100mg/ml

2ml

24.16

TRAMOL

Prem Pharma

INJ

50mg/ml

1ml AMP

15.00

INJ

50mg/ml

2ml AMP

24.00

TRASIC

Kopran

CAPS

50mg

10

54.00

TRD-CONTIN 100

Modi Mundipharma

CR TAB 

100mg

10

105.15

INJ

50mg/ml

1 AMP

13.00


Top

 

                                                     
                                               

 

By |2022-07-20T16:42:50+00:00July 20, 2022|Uncategorized|Comments Off on Tramadol

About the Author: