Drug Information








   


     


Trazodone











   

Pharmacokinetics


 

Trazodone is readily absorbed
from the gastrointestinal tract although absorption is affected by food.
When trazodone is taken shortly after a meal there may be an increase in
the amount absorbed, a decrease in the maximum concentration, and a
lengthening in the time to maximum concentration compared with the
fasting state; peak plasma concentrations occur about one hour after
administration when taken on an empty stomach and after about 2 hours
when taken with food. Protein binding is reported to be about 89 to 95%.



Trazodone is extensively metabolised in the liver and paths of
metabolism include N-oxidation and hydroxylation. The metabolite m-chlorophenylpiperazine
is active in animals. Trazodone is excreted predominantly in the urine
almost entirely in the form of its metabolites, either in free or in
conjugated form: some is excreted in the faeces via biliary elimination.
The elimination of trazodone from the plasma is biphasic, with a
terminal elimination half-life of 5 to 9 hours.

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Indication
& Dosage




Oral

PSYCHOTIC DEPRESSION, DEPRESSION WIHT ANXIETY AND INSOMNIA, SECONDARY
DEPRESSION IN SCHIZOPHRENIA AND CHRONIC ALCOHOLISM:
Start with 50mg/day at
bedtime for 3 days. Then increase to 100mg at bedtime. If well tolerated
additional 50mg/day every 3-4 days. Max daily dose: 400mg Maintenance:
Should be at as low a dose as possible. Children: Not indicated

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Action

A triazolopyridine antedepressant Selectively inhibits central
serotonin uptake. Also increases brain dopamine turnover. Peripheral
reuptake of noradrenaline is not prevented. Trazodone is not an MAO
inhibitor and has no CNS stimulant effect. Anticholinergic properties are
not significant.

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Interactions



Alchohol, Barbiturates
and other CNS depressants: Trazodone enhances the CNS depressant
effects of these drugs.

Digoxin: Serum levels of digoxin increased.

MAOIs: Exercise caution when coadministring  trazodone.

Phenytoin: Increased serum levels of phenytoin.

Warfarin: The hypoprothrombinemic effect of warfarin may be
decreased.


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Adverse
Effect & Precautions




Headache,
nausea, drowsiness, allergic reactions and dizziness. Priapism.

Precaution:
With other CNS depressants, ethanol. Hepatic, renal,
cardiovascular disease and epilepsy. Painful prolonged penis
erection and impotence may occur.

Pregnancy: Use with caution.

Breast Feeding: Use with caution.

Man: May be given in reduced dose.

Top

   



Brands available in market :
































DEPRYL-25


Protec


TAB


25mg


10


11.49


TAB


50mg


10


19.85


TAB


100mg


10


33.45


TAZODAC


Alidac


TAB


25mg


10


11.50


TAB


50mg


10


20.60


TRAZALON


Sun Pharma


TAB


25mg


10


15.00


TAB


50mg


10


30.00


TAB


100mg


10


43.72


TRAZE


LA Pharma


TAB


25mg


10


14.00


TAB


50mg


10


26.00


TAB


100mg


10


42.00


TRAZODEP


Torrent


CAPS


25mg


10


11.70


CAPS


50mg


10


22.50


CAPS


100mg


10


40.85


TRAZONIL


Intas


TAB


25mg


10


14.25


TAB


50mg


10


27.25


TAB


100mg


10


40.75


TRITTICO


Elder


TAB


25mg


10


13.05


TAB


50mg


10


23.30


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Drug Information

   

     
Trazodone

   
Pharmacokinetics

 
Trazodone is readily absorbed from the gastrointestinal tract although absorption is affected by food. When trazodone is taken shortly after a meal there may be an increase in the amount absorbed, a decrease in the maximum concentration, and a lengthening in the time to maximum concentration compared with the fasting state; peak plasma concentrations occur about one hour after administration when taken on an empty stomach and after about 2 hours when taken with food. Protein binding is reported to be about 89 to 95%.

Trazodone is extensively metabolised in the liver and paths of metabolism include N-oxidation and hydroxylation. The metabolite m-chlorophenylpiperazine is active in animals. Trazodone is excreted predominantly in the urine almost entirely in the form of its metabolites, either in free or in conjugated form: some is excreted in the faeces via biliary elimination. The elimination of trazodone from the plasma is biphasic, with a terminal elimination half-life of 5 to 9 hours.

Top
  

Indication & Dosage

Oral
PSYCHOTIC DEPRESSION, DEPRESSION WIHT ANXIETY AND INSOMNIA, SECONDARY DEPRESSION IN SCHIZOPHRENIA AND CHRONIC ALCOHOLISM:
Start with 50mg/day at bedtime for 3 days. Then increase to 100mg at bedtime. If well tolerated additional 50mg/day every 3-4 days. Max daily dose: 400mg Maintenance: Should be at as low a dose as possible. Children: Not indicated

Top
   

Action

A triazolopyridine antedepressant Selectively inhibits central serotonin uptake. Also increases brain dopamine turnover. Peripheral reuptake of noradrenaline is not prevented. Trazodone is not an MAO inhibitor and has no CNS stimulant effect. Anticholinergic properties are not significant.

Top
  

Interactions

Alchohol, Barbiturates and other CNS depressants: Trazodone enhances the CNS depressant effects of these drugs.
Digoxin: Serum levels of digoxin increased.
MAOIs: Exercise caution when coadministring  trazodone.
Phenytoin: Increased serum levels of phenytoin.
Warfarin: The hypoprothrombinemic effect of warfarin may be decreased.

Top

Adverse Effect & Precautions

Headache, nausea, drowsiness, allergic reactions and dizziness. Priapism.

Precaution: With other CNS depressants, ethanol. Hepatic, renal, cardiovascular disease and epilepsy. Painful prolonged penis erection and impotence may occur.
Pregnancy: Use with caution.
Breast Feeding: Use with caution.
Man: May be given in reduced dose.

Top
   

Brands available in market :

DEPRYL-25

Protec

TAB

25mg

10

11.49

TAB

50mg

10

19.85

TAB

100mg

10

33.45

TAZODAC

Alidac

TAB

25mg

10

11.50

TAB

50mg

10

20.60

TRAZALON

Sun Pharma

TAB

25mg

10

15.00

TAB

50mg

10

30.00

TAB

100mg

10

43.72

TRAZE

LA Pharma

TAB

25mg

10

14.00

TAB

50mg

10

26.00

TAB

100mg

10

42.00

TRAZODEP

Torrent

CAPS

25mg

10

11.70

CAPS

50mg

10

22.50

CAPS

100mg

10

40.85

TRAZONIL

Intas

TAB

25mg

10

14.25

TAB

50mg

10

27.25

TAB

100mg

10

40.75

TRITTICO

Elder

TAB

25mg

10

13.05

TAB

50mg

10

23.30

Top

 

                                                     
                                               

 

By |2022-07-20T16:44:42+00:00July 20, 2022|Uncategorized|Comments Off on Trazodone

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