Drug Information


   


    

Tretinoin

    










Pharmacokinetics

 

Following
oral administration tretinoin is well absorbed from the gastrointestinal
tract and peak plasma concentrations are obtained after 1 to 2 hours.
Oral bioavailability is about 50%. Tretinoin is highly bound to plasma
proteins. It undergoes metabolism in the liver. Metabolites include
isotretinoin, 4-oxo-trans-retinoic acid, and 4-oxo-cis-retinoic acid.
The terminal elimination half-life of tretinoin is 0.5 to 2 hours.
Tretinoin is excreted in the bile and the urine.

Top

 

Indication
& Dosage




Topical Skin

ACNE VULGARIS ESPECIALLY GRADES I, II & III:
0.025% and 0.05% w/w
cream. Apply gently once a day, Avoid rubbing.

Top

 



Action


 

Tretinoin is trans-retinoic acid, an acid form of vitimin A. It
stimulates mitosis and turnover of follicualr epithelial cells and reduce
their cohesiveness. This facilitates extrusionof existing comedones and
preventionof new comedone formation

Top

 



Interactions

 


Concomitant use of
isotretinoin and vitamin A (including dietary supplements) should
be avoided because of additive toxic effects. Tetracyclines should
be avoided as their use with isotretinoin has been associated with
the development of benign intracranial hypertension.

Tretinoin is metabolised by microsomal liver enzymes therefore
there is a potential for interaction between oral tretinoin and
inhibitors or inducers of these enzymes.

Top


 



Adverse
Effect & Precautions




Itching, redness, skin
peeling, stinging, xerosis of skin, photosensitivity.



Precaution: To avoid exposure to uv light, sunlight and
concomitant therapy with conventional acne, medical or cosmetic
therapy should be avoided.






Top

 



Brands available in market :














AIROL


Piramal Healthcare


CREAM


0.025%


20g


36.21


CREAM


0.05%


20g


38.21


EUDYNA


German Remedies


CREAM


0.05%


20g


49.20


RETINO-A


Ethnot


CREAM


0.025%


20g


42.36


CREAM


0.05%


20g


47.95







Top



  


                                                        
                                           






 

 

                       

  
Drug Information
   

    
Tretinoin
    

Pharmacokinetics
 
Following oral administration tretinoin is well absorbed from the gastrointestinal tract and peak plasma concentrations are obtained after 1 to 2 hours. Oral bioavailability is about 50%. Tretinoin is highly bound to plasma proteins. It undergoes metabolism in the liver. Metabolites include isotretinoin, 4-oxo-trans-retinoic acid, and 4-oxo-cis-retinoic acid. The terminal elimination half-life of tretinoin is 0.5 to 2 hours. Tretinoin is excreted in the bile and the urine.

Top

 

Indication & Dosage

Topical Skin
ACNE VULGARIS ESPECIALLY GRADES I, II & III:
0.025% and 0.05% w/w cream. Apply gently once a day, Avoid rubbing.

Top

 

Action
 
Tretinoin is trans-retinoic acid, an acid form of vitimin A. It stimulates mitosis and turnover of follicualr epithelial cells and reduce their cohesiveness. This facilitates extrusionof existing comedones and preventionof new comedone formation

Top

 

Interactions
 
Concomitant use of isotretinoin and vitamin A (including dietary supplements) should be avoided because of additive toxic effects. Tetracyclines should be avoided as their use with isotretinoin has been associated with the development of benign intracranial hypertension.
Tretinoin is metabolised by microsomal liver enzymes therefore there is a potential for interaction between oral tretinoin and inhibitors or inducers of these enzymes.

Top

 

Adverse Effect & Precautions

Itching, redness, skin peeling, stinging, xerosis of skin, photosensitivity.

Precaution: To avoid exposure to uv light, sunlight and concomitant therapy with conventional acne, medical or cosmetic therapy should be avoided.


Top

 

Brands available in market :

AIROL

Piramal Healthcare

CREAM

0.025%

20g

36.21

CREAM

0.05%

20g

38.21

EUDYNA

German Remedies

CREAM

0.05%

20g

49.20

RETINO-A

Ethnot

CREAM

0.025%

20g

42.36

CREAM

0.05%

20g

47.95


Top

  

                                                                                                    

 

By |2022-07-20T16:41:36+00:00July 20, 2022|Uncategorized|Comments Off on Tretinoin

About the Author: