Drug Information


   


  

Triamcinolone

   









 

Pharmacokinetics


 

The bio-availablity of
Triamcinolone is moderately high
after oral administration. It is
rapidy absorbed orally. It is
metabolised in the liver.

Top

 

Indication
& Dosage


 

Oral

BRONCHIAL ASTHAMA, ALLEGRGIES,
DERMATOSES, RHEUMOTOID ARTHRITIS
AND OTHER MUSUCLO-SKELETAL
INFLAMMATORY CONDITIONS,
CONNECTIVE TISSUE DISORDERS.
REPLACEMENT THERAPY ALONG WITH
MINERAL OCORTICOID IN STEROID
DEFIECIENCY STATES: 8-32mg daily
in single or divided doses.

Intra-articular

INFLAMMATORY JOINT DISEASE: 
2.5-15mg intra-articularly or
intradermal: 0.2-0.3ml (10mg/ml).
Alternatively IM Deep:
2.5-60mg/day, then taper. Children
6-12yrs: 40mg IM.

Top

  

Action

 

A synthetic glucocorticoid wiht
little mineralocorticoid action.
It has potent anti-inflammatory
action and alters body immune
responses. Given systemically
triamcinolone exhibits the typical
glucoccorticoid activity including
negative feedback suppression of the pituitary-adrenal axis. This
may result in corticosteroid deficiency
in stress situations.

Top

 




Interactions

 

Action blunted by
barbiturates, phenytoin,
rifampicin, cyclosporine
and previous long term
treatment with other
corticosteroids.
Absorption of
triamcinolone is reduced
by antacids. Triamcinolone
antogonises the
neuromuscular blockade by
pancuronium.

Top

 





Precautions

 

Special precautions have
to be taken in diabetes,
hypertension, CVS disease,
renal impairment,
glaucoma, elderly,
neonates,psychosis and in
hepatic cirrhosis.

Top

 


Brands
available in market :



















COMCORT

Comed
INJ 10mg/ml 10 14.70
INJ 40mg/ml 10 28.56
KENACORT

Sarabhai
TAB 4mg 10 19.10
INJ 10mg 1ml 19.27
INJ 40mg 1ml 37.40
LEDERCORT

Wyeth
Lederle
TAB 4mg 10 19.08
PERICORT-4

Themis
Chemicals
TAB 4mg 25×10 479.75
TRICORT

Alidac
TAB 4mg 10 10.73
INJ 10mg/ml 1ml 11.00
INJ 40mg/ml 1ml 26.98





Top


 

                                                     


                                               




 

  

  
Drug Information
   

  
Triamcinolone
   

 
Pharmacokinetics

 
The bio-availablity of Triamcinolone is moderately high after oral administration. It is rapidy absorbed orally. It is metabolised in the liver.

Top

 

Indication & Dosage
 
Oral
BRONCHIAL ASTHAMA, ALLEGRGIES, DERMATOSES, RHEUMOTOID ARTHRITIS AND OTHER MUSUCLO-SKELETAL INFLAMMATORY CONDITIONS, CONNECTIVE TISSUE DISORDERS. REPLACEMENT THERAPY ALONG WITH MINERAL OCORTICOID IN STEROID DEFIECIENCY STATES: 8-32mg daily in single or divided doses.

Intra-articular
INFLAMMATORY JOINT DISEASE:  2.5-15mg intra-articularly or intradermal: 0.2-0.3ml (10mg/ml). Alternatively IM Deep: 2.5-60mg/day, then taper. Children 6-12yrs: 40mg IM.

Top

  

Action
 
A synthetic glucocorticoid wiht little mineralocorticoid action. It has potent anti-inflammatory action and alters body immune responses. Given systemically triamcinolone exhibits the typical glucoccorticoid activity including negative feedback suppression of the pituitary-adrenal axis. This may result in corticosteroid deficiency in stress situations.

Top

 

Interactions
 
Action blunted by barbiturates, phenytoin, rifampicin, cyclosporine and previous long term treatment with other corticosteroids. Absorption of triamcinolone is reduced by antacids. Triamcinolone antogonises the neuromuscular blockade by pancuronium.

Top

 

Precautions
 
Special precautions have to be taken in diabetes, hypertension, CVS disease, renal impairment, glaucoma, elderly, neonates,psychosis and in hepatic cirrhosis.

Top

 

Brands available in market :

COMCORT

Comed

INJ

10mg/ml

10

14.70

INJ

40mg/ml

10

28.56

KENACORT

Sarabhai

TAB

4mg

10

19.10

INJ

10mg

1ml

19.27

INJ

40mg

1ml

37.40

LEDERCORT

Wyeth Lederle

TAB

4mg

10

19.08

PERICORT-4

Themis Chemicals

TAB

4mg

25×10

479.75

TRICORT

Alidac

TAB

4mg

10

10.73

INJ

10mg/ml

1ml

11.00

INJ

40mg/ml

1ml

26.98


Top

 

                                                     
                                               

 

By |2022-07-20T16:41:36+00:00July 20, 2022|Uncategorized|Comments Off on Triamcinolone

About the Author: