Drug Information

  


   

Trifluoperazine










Pharmacokinetics

A study of the
pharmacokinetics of trifluoperazine as a single 5-mg dose by mouth in 5
healthy subjects. (1) Peak plasma concentrations of trifluoperazine were
reached from 1.5 to 4.5 hours after ingestion and varied widely between
subjects, ranging from 0.53 to 3.09 ng per mL. Elimination of
trifluoperazine was multiphasic; the mean elimination half-life was
estimated to be 5.1 hours over the period from 4.5 to 12 hours after
ingestion, while the mean apparent terminal elimination half-life was
estimated to be 12.5 hours.

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Indication
& Dosage





Oral

SEVERE NAUSEA AND VOMITING:
2-4 daily in div doses. Children 3-5yrs:
1mg/day. 6-12yrs: upto 4mg daily.

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Action




Like other typical phenothiazine neuroleptics, trifluoperazine inhibits
dopamine D2 receptores. It has alpha-adrenergic blocking and some
anticholinergic activities. It has antiemetic activity. In psychotics
trifluoperazine controls severely distrubed, agitated or violent
behaviour. It may also be used for nonpsychotic anxiety. Trifluoperazine
may cause extrapyramindal side effects and tardiv dyskinesia

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Interactions



CNS depressants:
Potentiates their action.

Anticholinergic drugs: Side effects increased.

Antihistamines: Terfenadine and astemizole: Increased risk of
cardiac arrhythmias.

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Adverse
Effect & Precautions




Sedation,
dyskinesia, dystonia, anorexia, salivation, polyuria, headache,
dry mouth, constipation and blurred vision.



Precaution: Operating machinery  & driving vehicle.

Pregnancy: Use with caution.

Breast Feeding: Contraindicated.

Man: May be used in reduced dose.

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Brands available in market :



















NEOCALM


Intas


TAB


5mg


10


4.50


TAB


10mg


10


7.50


PSYCALM


Saga Labs


TABS


5mg


10


6.00


TABS


1mg


10


3.60


SIGMAZINE


Sigma


TAB


5mg


10


4.80


TAB


10mg


10


7.05


TRAZINE


Sun Pharma


TAB


5mg


10


4.48


PROMETHAZINE


Torrent


SYRUP


5mg


10


5.90


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Drug Information
  

   
Trifluoperazine

Pharmacokinetics

A study of the pharmacokinetics of trifluoperazine as a single 5-mg dose by mouth in 5 healthy subjects. (1) Peak plasma concentrations of trifluoperazine were reached from 1.5 to 4.5 hours after ingestion and varied widely between subjects, ranging from 0.53 to 3.09 ng per mL. Elimination of trifluoperazine was multiphasic; the mean elimination half-life was estimated to be 5.1 hours over the period from 4.5 to 12 hours after ingestion, while the mean apparent terminal elimination half-life was estimated to be 12.5 hours.

Top

 

Indication & Dosage

Oral
SEVERE NAUSEA AND VOMITING:
2-4 daily in div doses. Children 3-5yrs: 1mg/day. 6-12yrs: upto 4mg daily.

Top

 

Action

Like other typical phenothiazine neuroleptics, trifluoperazine inhibits dopamine D2 receptores. It has alpha-adrenergic blocking and some anticholinergic activities. It has antiemetic activity. In psychotics trifluoperazine controls severely distrubed, agitated or violent behaviour. It may also be used for nonpsychotic anxiety. Trifluoperazine may cause extrapyramindal side effects and tardiv dyskinesia

Top

 

Interactions

CNS depressants: Potentiates their action.
Anticholinergic drugs: Side effects increased.
Antihistamines: Terfenadine and astemizole: Increased risk of cardiac arrhythmias.

Top

 

Adverse Effect & Precautions

Sedation, dyskinesia, dystonia, anorexia, salivation, polyuria, headache, dry mouth, constipation and blurred vision.

Precaution: Operating machinery  & driving vehicle.
Pregnancy: Use with caution.
Breast Feeding: Contraindicated.
Man: May be used in reduced dose.

Top

 

Brands available in market :

NEOCALM

Intas

TAB

5mg

10

4.50

TAB

10mg

10

7.50

PSYCALM

Saga Labs

TABS

5mg

10

6.00

TABS

1mg

10

3.60

SIGMAZINE

Sigma

TAB

5mg

10

4.80

TAB

10mg

10

7.05

TRAZINE

Sun Pharma

TAB

5mg

10

4.48

PROMETHAZINE

Torrent

SYRUP

5mg

10

5.90

Top

 

                                                     
                                               

 

By |2022-07-20T16:44:30+00:00July 20, 2022|Uncategorized|Comments Off on Trifluoperazine

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