Drug Information

 


            




 











Pharmacokinetics


 


Ursodeoxycholic
acid is absorbed from the gastrointestinal tract and undergoes
enterohepatic recycling. It is partly conjugated in the liver before
being excreted into the bile. Under the influence of intestinal bacteria
the free and conjugated forms undergo 7alpha-dehydroxylation to
lithocholic acid, some of which is excreted directly in the faeces and
the rest absorbed and mainly conjugated and sulphated by the liver
before excretion in the faeces. However, in comparison with
chenodeoxycholic acid, less ursodeoxycholic acid undergoes such
bacterial degradation.

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Indication
& Dosage


 

RADIOLUCENT, 
NON-CALCIFIED GALLBLADDER STONES (less than 20mm ) IN GREATES DIAMETER: 


Adults: 8-12mg/kg obese patients to 15mg/kg) b.i.dm x up to 2 yrs;
treatment is continued for 3-4 months after dissolution of stones.

Children : Safety & Effectiveness not established.

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Action

 



It suppresses hepatic synthesis & secretion of cholesterol &
also inhibits intestinal absorption of cholesterol. In addition, it also
solubilizes cholesterol in micelles & causes dispersion of
cholesterol as liquid crystals in aqueous media. Overall, it makes the
bile conducive to cholesterol stones dissolution.

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Interactions

 


Chenodeoxycholic acid should not be used with drugs, such as
oestrogenic hormones, that increase bile cholesterol. Concomitant
administration with bile-acid binding drugs including antacids,
charcoal, and cholestyramine should be  avoided since this may
reduce the effectiveness of therapy with chenodeoxycholic acid.
 

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Adverse
Effect & Precaution


  

Ursodeoxycholic acid may cause nausea,
vomiting, and other gastrointestinal disturbances but diarrhoea is
reported to occur less frequently than with chenodeoxycholic acid.
Increased liver enzyme values are also less likely. However, treatment
with ursodeoxycholic acid may cause more calcification of cholesterol
stones than chenodeoxycholic acid.



Precaution: Suitable for patients not reatable by other means who have
mild symptoms unimpaired gall bladder functon and small or medium sized
radio lucent stones.

Pregnancy: Contraindicated

Breast Feeding: Contraindicated

Man: May be used

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Brand
available in market








U.D.C.A

 

 

Duphar-Interfran

TAB 150mg 30 186.21
URSO     Curewel
TAB 150mg 10 65.00
URSOLIV     Durga
CAPS 250mg 10 173.20

 

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Drug Information
 

            

 

Pharmacokinetics
 
Ursodeoxycholic acid is absorbed from the gastrointestinal tract and undergoes enterohepatic recycling. It is partly conjugated in the liver before being excreted into the bile. Under the influence of intestinal bacteria the free and conjugated forms undergo 7alpha-dehydroxylation to lithocholic acid, some of which is excreted directly in the faeces and the rest absorbed and mainly conjugated and sulphated by the liver before excretion in the faeces. However, in comparison with chenodeoxycholic acid, less ursodeoxycholic acid undergoes such bacterial degradation.

TOP
   

Indication & Dosage
 
RADIOLUCENT,  NON-CALCIFIED GALLBLADDER STONES (less than 20mm ) IN GREATES DIAMETER: 

Adults: 8-12mg/kg obese patients to 15mg/kg) b.i.dm x up to 2 yrs; treatment is continued for 3-4 months after dissolution of stones.
Children : Safety & Effectiveness not established.

TOP
   

Action
 
It suppresses hepatic synthesis & secretion of cholesterol & also inhibits intestinal absorption of cholesterol. In addition, it also solubilizes cholesterol in micelles & causes dispersion of cholesterol as liquid crystals in aqueous media. Overall, it makes the bile conducive to cholesterol stones dissolution.

TOP
    

Interactions
 
Chenodeoxycholic acid should not be used with drugs, such as oestrogenic hormones, that increase bile cholesterol. Concomitant administration with bile-acid binding drugs including antacids, charcoal, and cholestyramine should be  avoided since this may reduce the effectiveness of therapy with chenodeoxycholic acid.
 

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Adverse Effect & Precaution
  
Ursodeoxycholic acid may cause nausea, vomiting, and other gastrointestinal disturbances but diarrhoea is reported to occur less frequently than with chenodeoxycholic acid. Increased liver enzyme values are also less likely. However, treatment with ursodeoxycholic acid may cause more calcification of cholesterol stones than chenodeoxycholic acid.

Precaution: Suitable for patients not reatable by other means who have mild symptoms unimpaired gall bladder functon and small or medium sized radio lucent stones.
Pregnancy: Contraindicated
Breast Feeding: Contraindicated
Man: May be used

TOP

 

Brand available in market

U.D.C.A

 

 

Duphar-Interfran

TAB

150mg

30

186.21

URSO

 

 

Curewel

TAB

150mg

10

65.00

URSOLIV

 

 

Durga

CAPS

250mg

10

173.20

 

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By |2022-07-20T16:44:29+00:00July 20, 2022|Uncategorized|Comments Off on Ursodeoxycholic Acid

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