Drug Information




   











 


Pharmacokinetics


 

Vancomycin is not absorbed orally and intramuscular
injection is painful. It acts by inhibition of cell wall synthesis. It
is mainly excreted via urine.

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Indication
& Dosage


 

SERIOUS
INFECTIONS SUSPECTED TO BE CAUSED BY STAPHYLOCCOCCI OR STREPTOCOCCI SUCH
AS ENDOCCARDITIS, LOWER RTI, SEPTICAEMIA, BONE INFECTION, SKIN AND SOFT
TISSUE INFECTIONS:
Adults: 500mg 6 hrly or 1g 12 hrly. Children and
infants over 1 ,month: 40mg/kg/day in 4 divided doses. 60mg/kg/day in CNS
infections. Neonates 8-30 days: 15mg/kg followed by 10mgmg/kg 8 hrly.
Neonates less than 8 days old: 10mg/kg every 12 hrs after initial dose of
15mg/kg


PROPHYLAXIS DURING SURGICAL PROCEDURES SUCH AS CARDIAC  VALVE
REPLACEMENT, TOTAL HIP REPLACEMENT, PATIENTS WITH SEVERE INFECTIONS
UNDERGOING DENTAL OR UPPER RT SURGERY:
Adult: Infuse 1g over 30-60 mins
before surgery starts. Children: 20mg/kg.

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Action

 



Bactericidal action through inhibition of the cell wall synthesis. It
may also affect cell membrane permeability and RNA synthesis. Vancomycin
is active against Staph. aureus, Staph.epidermidis including
methicillian-resistant strains, Streptococci including Strep. pyogenes,
Strep.pneumoniae, Strep.agalactiae, viridans group, Enterococcus
faecalis, Clostriduim dificile, Diphtheroids, Listeria monocytogenes,
Clostrdium spp etc.

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Interactions

 

Patients with Renal disease, inflammatory bowel
disorders may have an increased chance of adverse effects. Rapid
infusion may lead to sudden, profound fall in blood pressure,
flushing,and itching (red man syndrome)

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Adverse
Effect & Precaution




Hypersensitivity reactions e.g. skin rash and anaphylaxis. Local pain
and phlebitis at site of intravenous injection. Nausea, chills, fever,
ototoxicity and nephrotoxicity. Hypotension, eosinophilia.

  

Cholestyramine, Colestipol : Use of these drugs with
oral vancomycin may decrease the effects of oral vancomycin; oral
vancomycin and these drugs should be taken several hours apart. Risk of
increased nephrotoxicity with concommitant aminoglycosides.
Neuromuscular blockade may occur if used together with non-depolarising
agents.

Pregnancy: Use with caution

Breast Feeding: Use with caution

Man: Use with Caution.

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Brand
available in market














VANCOCARE

 

 

Criticare

INJ

500mg/Vial

VIAL

362.34

INJ

1g/Vial

VIAL

704.55

VANCOCIN
CP

 

 

Ranbaxy

INJ

0.5gmg

VIAL

365.00

VANCOGEN

 

 

Alkem

INJ

0.5mg/Vial

1VIAL

335.00

VANCOLED

 

 

Wyeth
Lederle

INJ

0.5gm

VIAL

370.19

INJ

1g

VIAL

683.04

VANCORID
CP

 

 

Panacea

INJ

0.5gm

VIAL

295.00

 


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Drug Information
   

 
Pharmacokinetics

 
Vancomycin is not absorbed orally and intramuscular injection is painful. It acts by inhibition of cell wall synthesis. It is mainly excreted via urine.

  TOP
    

Indication & Dosage
 
SERIOUS INFECTIONS SUSPECTED TO BE CAUSED BY STAPHYLOCCOCCI OR STREPTOCOCCI SUCH AS ENDOCCARDITIS, LOWER RTI, SEPTICAEMIA, BONE INFECTION, SKIN AND SOFT TISSUE INFECTIONS:
Adults: 500mg 6 hrly or 1g 12 hrly. Children and infants over 1 ,month: 40mg/kg/day in 4 divided doses. 60mg/kg/day in CNS infections. Neonates 8-30 days: 15mg/kg followed by 10mgmg/kg 8 hrly. Neonates less than 8 days old: 10mg/kg every 12 hrs after initial dose of 15mg/kg
PROPHYLAXIS DURING SURGICAL PROCEDURES SUCH AS CARDIAC  VALVE REPLACEMENT, TOTAL HIP REPLACEMENT, PATIENTS WITH SEVERE INFECTIONS UNDERGOING DENTAL OR UPPER RT SURGERY: Adult: Infuse 1g over 30-60 mins before surgery starts. Children: 20mg/kg.

  TOP
    

Action
 
Bactericidal action through inhibition of the cell wall synthesis. It may also affect cell membrane permeability and RNA synthesis. Vancomycin is active against Staph. aureus, Staph.epidermidis including methicillian-resistant strains, Streptococci including Strep. pyogenes, Strep.pneumoniae, Strep.agalactiae, viridans group, Enterococcus faecalis, Clostriduim dificile, Diphtheroids, Listeria monocytogenes, Clostrdium spp etc.

  TOP
    

Interactions
 
Patients with Renal disease, inflammatory bowel disorders may have an increased chance of adverse effects. Rapid infusion may lead to sudden, profound fall in blood pressure, flushing,and itching (red man syndrome)

  TOP
    

Adverse Effect & Precaution

Hypersensitivity reactions e.g. skin rash and anaphylaxis. Local pain and phlebitis at site of intravenous injection. Nausea, chills, fever, ototoxicity and nephrotoxicity. Hypotension, eosinophilia.
  
Cholestyramine, Colestipol : Use of these drugs with oral vancomycin may decrease the effects of oral vancomycin; oral vancomycin and these drugs should be taken several hours apart. Risk of increased nephrotoxicity with concommitant aminoglycosides. Neuromuscular blockade may occur if used together with non-depolarising agents.
Pregnancy: Use with caution
Breast Feeding: Use with caution
Man: Use with Caution.

  TOP
    

Brand available in market

VANCOCARE

 

 

Criticare

INJ

500mg/Vial

VIAL

362.34

INJ

1g/Vial

VIAL

704.55

VANCOCIN CP

 

 

Ranbaxy

INJ

0.5gmg

VIAL

365.00

VANCOGEN

 

 

Alkem

INJ

0.5mg/Vial

1VIAL

335.00

VANCOLED

 

 

Wyeth Lederle

INJ

0.5gm

VIAL

370.19

INJ

1g

VIAL

683.04

VANCORID CP

 

 

Panacea

INJ

0.5gm

VIAL

295.00

 

  TOP
   

By |2022-07-20T16:44:29+00:00July 20, 2022|Uncategorized|Comments Off on Vancomycin

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